Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia

Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

(2017) Sinead O'Sullivan et al.   NEUROPHARMACOLOGY

Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia

(2016) Maryam Nazari et al.   BRAIN RESEARCH BULLETIN

Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency

(2016) Michael K. Schuhmann et al.   CURRENT NEUROVASCULAR RESEARCH

Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage

(2016) Na Sun et al.   STROKE

Effect of Sema4D on microglial function in middle cerebral artery occlusion mice

(2015) Toshinori Sawano et al.   GLIA

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling

(2015) Eunjung Moon et al.   MEDIATORS OF INFLAMMATION

Proteinase 3 Induces Neuronal Cell Death Through Microglial Activation

(2015) Kyu Suk Cho et al.   NEUROCHEMICAL RESEARCH

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia

(2015) Bhakta Prasad Gaire et al.   PLoS One

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blocking Lymphocyte Trafficking with FTY720 Prevents Inflammation-Sensitized Hypoxic–Ischemic Brain Injury in Newborns

(2014) Dianer Yang et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-8 is a Novel Pathogenetic Factor in Focal Cerebral Ischemia

(2014) Jeong Eun Han et al.   MOLECULAR NEUROBIOLOGY

Fingolimod for the Treatment of Intracerebral Hemorrhage

(2014) Ying Fu et al.   JAMA Neurology

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia–reperfusion injury

(2013) Ahrom Ham et al.   KIDNEY INTERNATIONAL

FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke

(2013) Robert Brunkhorst et al.   PLoS One

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Role of the Sphingosine Metabolism Pathway on Neurons Against Experimental Cerebral Ischemia in Rats

(2013) Yu Hasegawa et al.   Translational Stroke Research

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Sphingosine-1-Phosphate Receptor 1-Directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-Dependent Manner

(2012) G. Galicia-Rosas et al.   JOURNAL OF IMMUNOLOGY

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis

(2011) Jeffrey A. Cohen et al.   ANNALS OF NEUROLOGY

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Astrocyte Proliferation Following Stroke in the Mouse Depends on Distance from the Infarct

(2011) George E. Barreto et al.   PLoS One

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis

(2010) Kenji Chiba et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

(2009) Bozena Czech et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia

(2009) D. Nayak et al.   NEUROSCIENCE

NCX1 Expression and Functional Activity Increase in Microglia Invading the Infarct Core

(2009) Francesca Boscia et al.   STROKE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE