A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

(2013) Bryan W. Day et al.   CANCER CELL

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

(2013) Karen Rex et al.   PLoS One

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

(2012) Christina Ginkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

MMSAT: Automated Quantification of Metabolites in Selected Reaction Monitoring Experiments

(2011) Jason W. H. Wong et al.   ANALYTICAL CHEMISTRY

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

(2011) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

(2011) Leila Hejazi et al.   BIOCHEMICAL JOURNAL

Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF- B Pathway in Human Non-Small Cell Lung Cancer

(2011) L. Song et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Molecular targeting of glioblastoma: Drug discovery and therapies

(2011) Ren-Yuan Bai et al.   TRENDS IN MOLECULAR MEDICINE

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro

(2010) Viviana Anelli et al.   FASEB JOURNAL

Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Elimination of a Hydroxyl Group in FTY720 Dramatically Improves the Phosphorylation Rate

(2010) E. Jary et al.   MOLECULAR PHARMACOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61

(2009) Nicholas Young et al.   MOLECULAR CANCER RESEARCH

Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival

(2008) J. Li et al.   CLINICAL CANCER RESEARCH

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells

(2008) Zhijian Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE