PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

Loss of PINK1 Attenuates HIF-1  Induction by Preventing 4E-BP1-Dependent Switch in Protein Translation under Hypoxia

(2014) W. Lin et al.   JOURNAL OF NEUROSCIENCE

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

(2014) Carme Camps et al.   Molecular Cancer

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

(2014) Roberta Tufi et al.   NATURE CELL BIOLOGY

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

(2013) Samuel A. Hasson et al.   NATURE

A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling

(2013) M. Priyadarshini et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease

(2012) Olga Corti et al.   CURRENT OPINION IN NEUROBIOLOGY

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation

(2012) B. Brix et al.   JOURNAL OF NEUROSCIENCE

Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

(2012) Maura Calvani et al.   PLoS One

γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

(2012) Ruben Quintana-Cabrera et al.   Nature Communications

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Mitochondrial Quality Control and Dynamics in Parkinson's Disease

(2011) Melissa K. McCoy et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

(2010) David A. Patten et al.   MOLECULAR BIOLOGY OF THE CELL

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

(2009) Matthew E. Gegg et al.   PLoS One

Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites

(2008) P. W. Franks et al.   FASEB JOURNAL

Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation

(2008) J. Prestel et al.   JOURNAL OF NEUROLOGY