The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2014) Theresa N. T. Dang et al.   Frontiers in Aging Neuroscience

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Amyotrophic lateral sclerosis: Problems and prospects

(2013) Jemeen Sreedharan et al.   ANNALS OF NEUROLOGY

Pro-Oxidant Copper-Binding Mode of the Apo Form of ALS-Linked SOD1 Mutant H43R Denatured at Physiological Temperature

(2013) Nobuhiro Fujimaki et al.   BIOCHEMISTRY

Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons

(2013) Jia Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden

(2013) Ilaria Pelizzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

(2013) Hjalte Holm Andersen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

(2013) E. Tokuda et al.   HUMAN MOLECULAR GENETICS

Palmitoylation of Superoxide Dismutase 1 (SOD1) Is Increased for Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants

(2013) Sarah E. Antinone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain iron MRI: A biomarker for amyotrophic lateral sclerosis

(2013) Aleksandar Ignjatović et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

(2013) Julie D. Atkin et al.   JOURNAL OF NEUROCHEMISTRY

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities

(2013) Eiichi Tokuda et al.   NEUROBIOLOGY OF DISEASE

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Review: Iron metabolism and the role of iron in neurodegenerative disorders

(2013) M. Hadzhieva et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models

(2013) Z. Zhang et al.   NEUROSCIENCE

Cu2+ Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces

(2013) Francis Hane et al.   PLoS One

Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons

(2013) Jerònia Lladó et al.   Frontiers in Cellular Neuroscience

Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

(2012) Aleksandar Ignjatović et al.   Amyotrophic Lateral Sclerosis

Lysosomal Iron, Iron Chelation, and Cell Death

(2012) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

(2012) Per M. Roos et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Brain iron accumulation in aging and neurodegenerative disorders

(2012) Jesper Hagemeier et al.   Expert Review of Neurotherapeutics

Relationships between Disease Progression and Serum Levels of Lipid, Urate, Creatinine and Ferritin in Japanese Patients with Amyotrophic Lateral Sclerosis: A Cross-Sectional Study

(2012) Ken Ikeda et al.   INTERNAL MEDICINE

Effect of hepcidin on intracellular calcium in human osteoblasts

(2012) Guang-Fei Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis

(2012) M. Hadzhieva et al.   NEUROSCIENCE

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Elevated Serum Ferritin Is Associated with Reduced Survival in Amyotrophic Lateral Sclerosis

(2012) Yann Nadjar et al.   PLoS One

Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders

(2012) Tina Skjørringe et al.   Frontiers in Pharmacology

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

(2011) Sandrine Da Cruz et al.   CURRENT OPINION IN NEUROBIOLOGY

Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency

(2011) Elise J Mostad et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

(2011) Daniel F. Tardiff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant HFE H63D Protein Is Associated with Prolonged Endoplasmic Reticulum Stress and Increased Neuronal Vulnerability

(2011) Yiting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

(2011) Cynthia P. W. Soon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

(2011) Isao Hozumi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis

(2011) Qian Wang et al.   Neurodegenerative Diseases

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia

(2011) Nootchanat Mairuae et al.   NEUROSCIENCE LETTERS

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

(2011) Wei Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Mechanism of copper(II)-induced misfolding of Parkinson's disease protein

(2011) Frisco Rose et al.   Scientific Reports

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Molecular responses of calreticulin genes to iron overload and bacterial challenge in channel catfish (Ictalurus punctatus)

(2010) Hong Liu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Zinc induces depletion and aggregation of endogenous TDP-43

(2010) Aphrodite Caragounis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper and Zinc Metallation Status of Copper-Zinc Superoxide Dismutase from Amyotrophic Lateral Sclerosis Transgenic Mice

(2010) Herman L. Lelie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of iron deposition in conjunction with assessment of nerve fiber tract integrity in amyotrophic lateral sclerosis

(2010) Christian Langkammer et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Endoplasmic Reticulum Stress in Motor Neurons of the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis

(2010) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

(2010) Ryan M. Mitchell et al.   MUSCLE & NERVE

Copper Homeostasis: The Role of Cellular Transporters

(2010) Edward D. Harris   NUTRITION REVIEWS

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation of Copper–Zinc Superoxide Dismutase in Familial and Sporadic ALS

(2009) Madhuri Chattopadhyay et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of hepcidin in murine brain iron metabolism

(2009) S.-M. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

(2009) Sai V. Seetharaman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

(2009) Lana Kupershmidt et al.   FASEB JOURNAL

Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease

(2009) Ning Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) S. Y. Jeong et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy

(2009) Anna Cozzi et al.   NEUROBIOLOGY OF DISEASE

Brain iron homeostasis and neurodegenerative disease

(2009) E. E. Benarroch   NEUROLOGY

Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)

(2009) Johannes Brettschneider et al.   NEUROSCIENCE LETTERS

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

The expression of metallothioneins is diminished in the spinal cords of patients with sporadic ALS

(2008) Isao Hozumi et al.   Amyotrophic Lateral Sclerosis

Iron, the substantia nigra and related neurological disorders

(2008) Amanda M. Snyder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

(2008) Eiichi Tokuda et al.   EXPERIMENTAL NEUROLOGY

Dysregulation of systemic iron metabolism in alcoholic liver diseases

(2008) Yutaka Kohgo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients

(2008) E. F. Goodall et al.   JOURNAL OF NEUROLOGY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Free Copper, Ferroxidase and SOD1 Activities, Lipid Peroxidation and NO x Content in the CSF. A Different Marker Profile in Four Neurodegenerative Diseases

(2008) Marie-Catherine Boll et al.   NEUROCHEMICAL RESEARCH

Differential expression of ceruloplasmin isoforms in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

(2008) Antonio Conti et al.   Proteomics Clinical Applications