Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice

Cytotoxic CD8+T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

(2019) Emmanuelle Coque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota in ALS: possible role in pathogenesis?

(2019) Pamela A. McCombe et al.   Expert Review of Neurotherapeutics

Core Gut Bacteria Analysis of Healthy Mice

(2019) Jingjing Wang et al.   Frontiers in Microbiology

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression

(2019) Ingrid S. Tarr et al.   Scientific Reports

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

(2018) Kate Joanne Howell et al.   GASTROENTEROLOGY

Inflammation, Immunity, and ALS, Part II: Immune-modulating therapies

(2018) Marlena Wosiski-Kuhn et al.   MUSCLE & NERVE

The fecal microbiome of ALS patients

(2018) David Brenner et al.   NEUROBIOLOGY OF AGING

The Role of Regulatory T Lymphocytes in Amyotrophic Lateral Sclerosis

(2018) David R. Beers et al.   JAMA Neurology

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis

(2018) Jason R. Thonhoff et al.   CURRENT OPINION IN NEUROLOGY

Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome

(2018) Mary Ni Lochlainn et al.   Nutrients

The UNITE database for molecular identification of fungi: handling dark taxa and parallel taxonomic classifications

(2018) Rolf Henrik Nilsson et al.   NUCLEIC ACIDS RESEARCH

Exact sequence variants should replace operational taxonomic units in marker-gene data analysis

(2017) Benjamin J Callahan et al.   ISME Journal

Crosstalk between the microbiome and epigenome: messages from bugs

(2017) Yufeng Qin et al.   JOURNAL OF BIOCHEMISTRY

What is “Hyper” in the ALS Hypermetabolism?

(2017) Alberto Ferri et al.   MEDIATORS OF INFLAMMATION

Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury

(2017) Kristina A. Kigerl et al.   Neurotherapeutics

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

(2017) Michael P. Gustafson et al.   PLoS One

Distinct cellular and molecular environments support aging-related DNA methylation changes in the substantia nigra

(2017) Maria Fasolino et al.   Epigenomics

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

(2017) Ashutosh Mangalam et al.   Cell Reports

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health

(2017) Chad M. Novince et al.   Scientific Reports

Gut microbiome and lipid metabolism

(2016) Zheng Wang et al.   CURRENT OPINION IN LIPIDOLOGY

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

(2016) Claudia Figueroa-Romero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uncovering the Role of the Methylome in Dementia and Neurodegeneration

(2016) Hans-Ulrich Klein et al.   TRENDS IN MOLECULAR MEDICINE

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Association of Environmental Toxins With Amyotrophic Lateral Sclerosis

(2016) Feng-Chiao Su et al.   JAMA Neurology

The Autoimmune Ecology

(2016) Juan-Manuel Anaya et al.   Frontiers in Immunology

Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina

(2016) E. G. O’Koren et al.   Scientific Reports

Tax4Fun: predicting functional profiles from metagenomic 16S rRNA data: Fig. 1.

(2015) Kathrin P. Aßhauer et al.   BIOINFORMATICS

Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease

(2015) Anna M. Seekatz et al.   INFECTION AND IMMUNITY

Composition and temporal stability of the gut microbiota in older persons

(2015) Ian B Jeffery et al.   ISME Journal

Impaired Bone Homeostasis in Amyotrophic Lateral Sclerosis Mice with Muscle Atrophy

(2015) Ke Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle-Derived Extracellular Signal-Regulated Kinases 1 and 2 Are Required for the Maintenance of Adult Myofibers and Their Neuromuscular Junctions

(2015) Bonnie Seaberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

(2015) Melanie Greter et al.   Frontiers in Immunology

The role of the adaptive immune system in regulation of gut microbiota

(2014) Lucia M. Kato et al.   IMMUNOLOGICAL REVIEWS

Early or Late IL-10 Blockade Enhances Th1 and Th17 Effector Responses and Promotes Fungal Clearance in Mice with Cryptococcal Lung Infection

(2014) Benjamin J. Murdock et al.   JOURNAL OF IMMUNOLOGY

NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study

(2014) Robert G. Miller et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine

(2014) Adriano Chiò et al.   JAMA Neurology

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

(2014) Sahar Al-Mahdawi et al.   Frontiers in Neuroscience

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity

(2013) Marlene Remely et al.   GENE

Interleukin-17A Enhances Host Defense against Cryptococcal Lung Infection through Effects Mediated by Leukocyte Recruitment, Activation, and Gamma Interferon Production

(2013) Benjamin J. Murdock et al.   INFECTION AND IMMUNITY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Ribosomal Database Project: data and tools for high throughput rRNA analysis

(2013) James R. Cole et al.   NUCLEIC ACIDS RESEARCH

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

(2013) Paul J. McMurdie et al.   PLoS One

Improvement of Neuromuscular Synaptic Phenotypes without Enhanced Survival and Motor Function in Severe Spinal Muscular Atrophy Mice Selectively Rescued in Motor Neurons

(2013) Ximena Paez-Colasante et al.   PLoS One

Interleukin-17 Drives Pulmonary Eosinophilia following Repeated Exposure to Aspergillus fumigatus Conidia

(2012) Benjamin J. Murdock et al.   INFECTION AND IMMUNITY

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral nerve inflammation in ALS mice: cause or consequence

(2012) O. Kano et al.   NEUROLOGY

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS

(2011) Arseny Finkelstein et al.   PLoS One

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis

(2011) Ilan Vaknin et al.   PLoS One

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Coevolution of TH1, TH2, and TH17 Responses during Repeated Pulmonary Exposure toAspergillus fumigatusConidia

(2010) Benjamin J. Murdock et al.   INFECTION AND IMMUNITY

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Characterization of a Novel SOD-1(G93A) Transgenic Mouse Line with Very Decelerated Disease Development

(2010) Alexandre Henriques et al.   PLoS One

Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

(2009) D. Keizman et al.   ACTA NEUROLOGICA SCANDINAVICA

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

(2009) P. D. Schloss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

A High-Throughput DNA Sequence Aligner for Microbial Ecology Studies

(2009) Patrick D. Schloss   PLoS One

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

(2009) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2008) Rebecca Banerjee et al.   PLoS One

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA