Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Genetic and epigenetic study of ALS-discordant identical twins with double mutations inSOD1andARHGEF28

(2016) Ming Zhang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The role of epigenetics in genetic and environmental epidemiology

(2016) Christine Ladd-Acosta et al.   Epigenomics

Age-Related Uptake of Heavy Metals in Human Spinal Interneurons

(2016) Roger Pamphlett et al.   PLoS One

RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord

(2016) David G. Brohawn et al.   PLoS One

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis

(2015) Fumiaki Mori et al.   NEUROSCIENCE LETTERS

Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS

(2015) Karyn Meltz Steinberg et al.   Scientific Reports

Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis

(2015) Karyn Meltz Steinberg et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

(2015) Xu Gao et al.   Clinical Epigenetics

Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles

(2015) Georg Haase et al.   Frontiers in Neuroscience

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

(2014) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Common genetic variants and the heritability of ALS

(2014) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis

(2014) Julien Couthouis et al.   PLoS Genetics

Contribution of genetic variation to transgenerational inheritance of DNA methylation

(2014) Allan F McRae et al.   GENOME BIOLOGY

Genome-Wide Analysis of the Heritability of Amyotrophic Lateral Sclerosis

(2014) Margaux F. Keller et al.   JAMA Neurology

Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression

(2013) Gaëlle Bruneteau et al.   BRAIN

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Can ALS-Associated C9orf72 Repeat Expansions Be Diagnosed on a Blood DNA Test Alone?

(2013) Roger Pamphlett et al.   PLoS One

Identification of In Vivo, Conserved, TAF15 RNA Binding Sites Reveals the Impact of TAF15 on the Neuronal Transcriptome

(2013) Fadia Ibrahim et al.   Cell Reports

Genetic and epigenetic studies of amyotrophic lateral sclerosis

(2013) Ammar Al-Chalabi et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis

(2013) Roger Pamphlett et al.   Acta Neuropathologica Communications

Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis?

(2012) Martin R. Turner et al.   Amyotrophic Lateral Sclerosis

Decreased motor cortex  -aminobutyric acid in amyotrophic lateral sclerosis

(2012) B. R. Foerster et al.   NEUROLOGY

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

(2012) Kristina Gervin et al.   PLoS Genetics

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

(2012) Altuna Akalin et al.   GENOME BIOLOGY

A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples

(2011) Thuc Le et al.   ANALYTICAL BIOCHEMISTRY

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

(2011) Juan Sandoval et al.   Epigenetics

Monozygotic twins discordant for neurofibromatosis type 1 due to a postzygotic NF1 gene mutation

(2011) Julia Vogt et al.   HUMAN MUTATION

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

(2011) Hongcang Gu et al.   Nature Protocols

The Heritability of Amyotrophic Lateral Sclerosis in a Clinically Ascertained United States Research Registry

(2011) Thomas S. Wingo et al.   PLoS One

An estimate of amyotrophic lateral sclerosis heritability using twin data

(2010) A. Al-Chalabi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis

(2009) Julia M. Morahan et al.   Amyotrophic Lateral Sclerosis

Defining the mechanisms that underlie cortical hyperexcitability in amyotrophic lateral sclerosis

(2009) Steve Vucic et al.   EXPERIMENTAL NEUROLOGY

Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)

(2009) Lubin Fang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Study of 962 patients indicates progressive muscular atrophy is a form of ALS

(2009) W. -K. Kim et al.   NEUROLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY