Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

(2020) Jorge Larios et al.   JOURNAL OF CELL BIOLOGY

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice

(2020) Milena Armacki et al.   GASTROENTEROLOGY

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exocytosis: A New Exocyst Movie

(2019) Kunrong Mei et al.   CURRENT BIOLOGY

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

(2019) Aysegul Sapmaz et al.   Nature Communications

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

(2019) Eun-Ju Im et al.   Nature Communications

Contribution of the cytoplasmic determinants of Vpu to the expansion of virus containing compartments in HIV-1 infected macrophages

(2019) Olivier Leymarie et al.   JOURNAL OF VIROLOGY

Syntenin regulates Hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes

(2019) Libin Deng et al.   JOURNAL OF HEPATOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Increased expression levels of Syntaxin 1A and Synaptobrevin 2/Vesicle-Associated Membrane Protein-2 are associated with the progression of bladder cancer

(2019) Sadaf Azad Raja et al.   GENETICS AND MOLECULAR BIOLOGY

Autophagy-Dependent Secretion: Mechanism, Factors Secreted, and Disease Implications

(2019) Jacob New et al.   Autophagy

Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells

(2019) Kaizhe Wang et al.   ACS Nano

Acidosis and proteolysis in the tumor microenvironment

(2019) Kyungmin Ji et al.   CANCER AND METASTASIS REVIEWS

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

(2019) Arash Latifkar et al.   DEVELOPMENTAL CELL

Dysregulated autophagy and lysosome function are linked to exosome production via miR‐155 in alcoholic liver disease

(2019) Mrigya Babuta et al.   HEPATOLOGY

The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy

(2019) Tingting Huang et al.   Molecular Cancer

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

(2019) Liang Yang et al.   Molecular Cancer

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

(2019) Lin Song et al.   Nature Communications

SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors

(2019) Seiichi Koike et al.   Nature Communications

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

(2019) Marte Sneeggen et al.   Nature Communications

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells

(2019) Gábor Valcz et al.   Journal of Extracellular Vesicles

Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p

(2019) Jie Xu et al.   CANCER RESEARCH

The role of exosomal PD-L1 in tumor progression and immunotherapy

(2019) Feiting Xie et al.   Molecular Cancer

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

(2018) Elisabet Barbero-Camps et al.   Autophagy

Extracellular vesicles and anti-Cancer drug resistance

(2018) Niamh Mc Namee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Novelty and Significance

(2018) Jaume Amengual et al.   CIRCULATION RESEARCH

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins

(2018) Jian-Hong Fang et al.   HEPATOLOGY

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

(2018) Scott W. Messenger et al.   JOURNAL OF CELL BIOLOGY

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

(2018) Claudia Verderio et al.   JOURNAL OF LIPID RESEARCH

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking

(2018) Lauren V. Albrecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

(2018) Qiang Cai et al.   SCIENCE

ESCRT and autophagies: Endosomal functions and beyond

(2018) Christophe Lefebvre et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ESCRT-dependent cargo sorting at multivesicular endosomes

(2018) E.B. Frankel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

(2018) Fruzsina Hobor et al.   Nature Communications

Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation

(2018) Eva Maria Wenzel et al.   Nature Communications

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

(2018) James Monypenny et al.   Cell Reports

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

(2018) Yoav Binenbaum et al.   CANCER RESEARCH

Inhibition of Cyclin-dependent Kinase 5 - a Novel Strategy to Improve Sorafenib Response in HCC Therapy

(2018) Maximilian A. Ardelt et al.   HEPATOLOGY

Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation

(2018) Sandra Atienzar-Aroca et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Hsp90 Mediates Membrane Deformation and Exosome Release

(2018) Elsa Lauwers et al.   MOLECULAR CELL

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

(2018) Frank F. Heisler et al.   NEURON

UBL3 modification influences protein sorting to small extracellular vesicles

(2018) Hiroshi Ageta et al.   Nature Communications

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

(2018) Michael E. Coulter et al.   Cell Reports

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

(2018) Jingxuan Yang et al.   GASTROENTEROLOGY

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

(2018) Israel Cotzomi-Ortega et al.   MEDIATORS OF INFLAMMATION

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling

(2018) Youn-Sang Jung et al.   NATURE CELL BIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation

(2018) Erin Kate McNally et al.   Nature Communications

Exocyst dynamics during vesicle tethering and fusion

(2018) Syed Mukhtar Ahmed et al.   Nature Communications

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling

(2017) Jared C. Weddell et al.   Integrative Biology

Autophagy promotes degradation of polyethyleneimine–alginate nanoparticles in endothelial progenitor cells

(2017) Guo-dong Wang et al.   International Journal of Nanomedicine

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins

(2017) Ken Cadwell et al.   JOURNAL OF CELL BIOLOGY

High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells

(2017) Xi-Long Zhao et al.   JOURNAL OF PATHOLOGY

VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia

(2017) Juan-Juan Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

(2017) Yun Teng et al.   Nature Communications

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function

(2017) Christian Grimm et al.   Frontiers in Pharmacology

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

(2017) Ying-Da Chen et al.   Scientific Reports

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Selective endosomal microautophagy is starvation-inducible in Drosophila

(2016) Anindita Mukherjee et al.   Autophagy

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The comings and goings of MHC class I molecules herald a new dawn in cross-presentation

(2016) J. Magarian Blander   IMMUNOLOGICAL REVIEWS

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis

(2016) Hao Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro

(2016) Zhen Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass

(2016) Gábor Valcz et al.   MODERN PATHOLOGY

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

(2016) Peter J. Wen et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

(2015) Zhi-Hua Chen et al.   Autophagy

Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR

(2015) Sheng Sun et al.   BIOCHEMICAL JOURNAL

Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology

(2015) Samikshan Dutta et al.   CANCER RESEARCH

Resolving sorting mechanisms into exosomes

(2015) Willem Stoorvogel   CELL RESEARCH

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane

(2015) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations

(2015) Marvin Bentley et al.   JOURNAL OF CELL BIOLOGY

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

Nbr1, a Receptor for ESCRT-Dependent Endosomal Microautophagy in Fission Yeast

(2015) Noboru Mizushima   MOLECULAR CELL

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Sorting of Clathrin-Independent Cargo Proteins Depends on Rab35 Delivered by Clathrin-Mediated Endocytosis

(2015) Dipannita Dutta et al.   TRAFFIC

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

(2015) P Majumder et al.   Cell Death & Disease

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

(2014) Anne-Maria Poehler et al.   Autophagy

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients

(2014) Roberta Nardacci et al.   Autophagy

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Exosomes and Cardiac Repair After Myocardial Infarction

(2014) Susmita Sahoo et al.   CIRCULATION RESEARCH

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

(2014) Manuel Alonso Y Adell et al.   JOURNAL OF CELL BIOLOGY

Quality control at the plasma membrane: One mechanism does not fit all

(2014) Markus Babst   JOURNAL OF CELL BIOLOGY

Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography

(2014) Emanuel T. Fertig et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

The balance of protein expression and degradation: an ESCRTs point of view

(2013) Markus Babst et al.   CURRENT OPINION IN CELL BIOLOGY

Endosomal Type Iγ PIP 5-Kinase Controls EGF Receptor Lysosomal Sorting

(2013) Yue Sun et al.   DEVELOPMENTAL CELL

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Immune synapse: conductor of orchestrated organelle movement

(2013) Noa Beatriz Martín-Cófreces et al.   TRENDS IN CELL BIOLOGY

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

(2013) Sovan Sarkar et al.   Cell Reports

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake

(2012) Yusong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Routing Misfolded Proteins through the Multivesicular Body (MVB) Pathway Protects against Proteotoxicity

(2011) Songyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Quantitative analysis of multivesicular bodies (MVBs) in the hypoglossal nerve: Evidence that neurotrophic factors do not use MVBs for retrograde axonal transport

(2009) Amy L. Altick et al.   JOURNAL OF COMPARATIVE NEUROLOGY

RISC hitches onto endosome trafficking

(2009) Haruhiko Siomi et al.   NATURE CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE