A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles

(2017) Sang Su Woo et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The emerging roles of exosomes in tumor–stroma interaction

(2016) Hailong Fu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses

(2016) Jing He et al.   MOLECULAR BIOLOGY OF THE CELL

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Tetherin is an exosomal tether

(2016) James R Edgar et al.   eLife

Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37

(2016) Hironori Higashio et al.   Scientific Reports

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion

(2015) M. C. Chicka et al.   BIOCHEMICAL JOURNAL

Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration

(2015) Nadine Déliot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

STIM1/ORAI1-mediated Ca2+Influx Regulates Enolase-1 Exteriorization

(2015) Miroslava Didiasova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane

(2015) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

STIM1- and Orai1-mediated Ca2+oscillation orchestrates invadopodium formation and melanoma invasion

(2014) Jianwei Sun et al.   JOURNAL OF CELL BIOLOGY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

Extracellular vesicles: emerging targets for cancer therapy

(2014) Pieter Vader et al.   TRENDS IN MOLECULAR MEDICINE

Current methods for the isolation of extracellular vesicles

(2013) Fatemeh Momen-Heravi et al.   BIOLOGICAL CHEMISTRY

Ca2+–Sensor Proteins in the Autophagic and Endocytic Traffic

(2013) Ghita Ghislat et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Tumor cell-derived exosomes: A message in a bottle

(2012) Pedram Kharaziha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Calcium Channels and Pumps in Cancer: Changes and Consequences

(2012) Gregory R. Monteith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

(2012) Paola Filipazzi et al.   SEMINARS IN CANCER BIOLOGY

Ion channels and transporters in cancer. 4. Remodeling of Ca2+ signaling in tumorigenesis: role of Ca2+ transport

(2011) Jane M. Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Glycogene Expression Alterations Associated with Pancreatic Cancer Epithelial-Mesenchymal Transition in Complementary Model Systems

(2010) Kevin A. Maupin et al.   PLoS One

ConceptGen: a gene set enrichment and gene set relation mapping tool

(2009) Maureen A. Sartor et al.   BIOINFORMATICS

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY