Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation

(2014) D Srivastava et al.   Cell Death & Disease

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Levels of the Mahogunin Ring Finger 1 E3 Ubiquitin Ligase Do Not Influence Prion Disease

(2013) Derek Silvius et al.   PLoS One

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity

(2013) Deepak Chhangani et al.   Scientific Reports

A Knockout of the Tsg101 Gene Leads to Decreased Expression of ErbB Receptor Tyrosine Kinases and Induction of Autophagy Prior to Cell Death

(2012) Chantey R. Morris et al.   PLoS One

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes: Figure 1

(2010) Daniel Metcalf et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations

(2010) Hazel Urwin et al.   HUMAN MOLECULAR GENETICS

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein

(2010) Neena S. Rane et al.   JOURNAL OF CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

ESCRTs and human disease

(2009) Suraj Saksena et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

(2009) Jian Jiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

How do ESCRT proteins control autophagy?

(2009) T. E. Rusten et al.   JOURNAL OF CELL SCIENCE

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

(2009) Tokimasa Hida et al.   Pigment Cell & Melanoma Research

Loss of Hrs in the Central Nervous System Causes Accumulation of Ubiquitinated Proteins and Neurodegeneration

(2008) Keiichi Tamai et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes

(2008) Rafael Mattera et al.   EMBO JOURNAL

Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase

(2007) Bethan McDonald et al.   MOLECULAR BIOLOGY OF THE CELL