ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

(2019) Ana T. López-Jiménez et al.   PLoS Pathogens

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome-related organelles as functional adaptations of the endolysosomal system

(2019) Cédric Delevoye et al.   CURRENT OPINION IN CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

(2017) Francesc X. Guix et al.   Molecular Neurodegeneration

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

(2017) Mingyu Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

(2017) Manuel Alonso Y Adell et al.   eLife

In Vitro Polymerization of F-actin on Early Endosomes

(2017) Olivia Muriel et al.   Jove-Journal of Visualized Experiments

The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3

(2016) Jessica Yu et al.   BIOCHEMICAL JOURNAL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

(2016) Yu Shi et al.   CELL DEATH AND DIFFERENTIATION

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation

(2016) Yolanda Olmos et al.   CURRENT BIOLOGY

Exosomes in developmental signalling

(2016) Ian John McGough et al.   DEVELOPMENT

ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission

(2016) Liliane Christ et al.   JOURNAL OF CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

(2016) Shaogeng Tang et al.   eLife

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif

(2016) Michael R. Dores et al.   PLoS One

ATG12–ATG3 connects basal autophagy and late endosome function

(2015) Lyndsay Murrow et al.   Autophagy

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

Tetraspan cargo adaptors usher GPI-anchored proteins into multivesicular bodies

(2015) Chris MacDonald et al.   CELL CYCLE

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production

(2015) Bo Meng et al.   Retrovirology

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

(2015) Guillaume van Niel et al.   Cell Reports

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

(2015) Shaogeng Tang et al.   eLife

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

(2014) Manuel Alonso Y Adell et al.   JOURNAL OF CELL BIOLOGY

Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly

(2014) Qing-Tao Shen et al.   JOURNAL OF CELL BIOLOGY

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endosomal vesicles as vehicles for viral genomes

(2014) Adel M. Nour et al.   TRENDS IN CELL BIOLOGY

Ubiquitin-Dependent Sorting in Endocytosis

(2014) R. C. Piper et al.   Cold Spring Harbor Perspectives in Biology

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

(2013) Natasha Pashkova et al.   DEVELOPMENTAL CELL

Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

(2013) Christin Bissig et al.   DEVELOPMENTAL CELL

Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding

(2013) Tal Keren-Kaplan et al.   EMBO JOURNAL

Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor

(2013) Elena Odintsova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

(2012) Dara P. Dowlatshahi et al.   DEVELOPMENTAL CELL

Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner

(2012) Yetao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

(2011) Lee Kamentsky et al.   BIOINFORMATICS

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Activation of the Retroviral Budding Factor ALIX

(2011) Q. Zhai et al.   JOURNAL OF VIROLOGY

Role of SNX16 in the Dynamics of Tubulo-Cisternal Membrane Domains of Late Endosomes

(2011) Ben Brankatschk et al.   PLoS One

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission

(2011) N. Elia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

Decoding the intrinsic mechanism that prohibits ALIX interaction with ESCRT and viral proteins

(2010) Xi Zhou et al.   BIOCHEMICAL JOURNAL

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation

(2010) David Teis et al.   EMBO JOURNAL

Functional Reconstitution of ESCRT-III Assembly and Disassembly

(2009) Suraj Saksena et al.   CELL

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments

(2009) Ricardo Pires et al.   STRUCTURE

The HIV-1 p6/EIAV p9 docking site in Alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody

(2008) Xi Zhou et al.   BIOCHEMICAL JOURNAL

The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix

(2008) Xi Zhou et al.   BIOCHEMICAL JOURNAL

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4)

(2008) Fumitaka Ichioka et al.   FEBS Journal

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release

(2008) J. G. Carlton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets

(2008) I. Hurbain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis

(2008) A. Doyotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical Structures of ESCRT-III Are Disassembled by VPS4

(2008) S. Lata et al.   SCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

The ESCRT-I Subunit TSG101 Controls Endosome-to-Cytosol Release of Viral RNA

(2008) Pierre-Philippe Luyet et al.   TRAFFIC

Functional Replacement of a Retroviral Late Domain by Ubiquitin Fusion

(2008) Anjali Joshi et al.   TRAFFIC