Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

(2014) Maria Xilouri et al.   Autophagy

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

(2013) Wei Xiang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Increased membrane shedding – indicated by an elevation of CD133-enriched membrane particles – into the CSF in partial epilepsy

(2011) Hagen B. Huttner et al.   EPILEPSY RESEARCH

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

(2010) Jia-Yi Li et al.   MOVEMENT DISORDERS

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Cell-derived microparticles: a new challenge in neuroscience

(2009) Loïc Doeuvre et al.   JOURNAL OF NEUROCHEMISTRY

Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology

(2009) Karin M. Danzer et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

(2009) Kristen A Malkus et al.   Molecular Neurodegeneration

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems

(2008) Nicholas MacInnes et al.   JOURNAL OF NEURAL TRANSMISSION

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS