The biology of brain metastases—translation to new therapies

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape

(2011) E. di Tomaso et al.   CANCER RESEARCH

MicroRNA-1258 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase

(2011) L. Zhang et al.   CANCER RESEARCH

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

(2011) Sachie Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

35th ESMO Congress Organization

(2010)   ANNALS OF ONCOLOGY

FOXC1 Is a Potential Prognostic Biomarker with Functional Significance in Basal-like Breast Cancer

(2010) P. S. Ray et al.   CANCER RESEARCH

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis

(2010) Toshihiro Seike et al.   CLINICAL & EXPERIMENTAL METASTASIS

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Association Between Being Underweight and Outcomes in Breast Cancer: Alternative Explanations

(2010) Min-Han Tan et al.   JOURNAL OF CLINICAL ONCOLOGY

Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study

(2010) Martin Kocher et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy and safety of bevacizumab in active brain metastases from non-small cell lung cancer

(2010) Kevin C. De Braganca et al.   JOURNAL OF NEURO-ONCOLOGY

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer

(2010) A. F. Eichler et al.   NEURO-ONCOLOGY

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative T2* imaging of metastatic human breast cancer to brain in the nude rat at 3 T

(2010) Ho-Taek Song et al.   NMR IN BIOMEDICINE

C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells

(2010) S. Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the organ microenvironment in brain metastasis

(2010) Isaiah J. Fidler   SEMINARS IN CANCER BIOLOGY

A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer

(2009) T Neuhaus et al.   BRITISH JOURNAL OF CANCER

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model

(2009) Juan JuanYin et al.   CLINICAL & EXPERIMENTAL METASTASIS

The Expression of Three Genes in Primary Non-Small Cell Lung Cancer Is Associated with Metastatic Spread to the Brain

(2009) H. Grinberg-Rashi et al.   CLINICAL CANCER RESEARCH

Bevacizumab Safety in Patients with Central Nervous System Metastases

(2009) B. Besse et al.   CLINICAL CANCER RESEARCH

Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks

(2009) D. Palmieri et al.   CLINICAL CANCER RESEARCH

Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer

(2009) N. U. Lin et al.   CLINICAL CANCER RESEARCH

Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis

(2009) Langley   INTERNATIONAL JOURNAL OF ONCOLOGY

Safety of Bevacizumab in Patients With Non–Small-Cell Lung Cancer and Brain Metastases

(2009) Mark A. Socinski et al.   JOURNAL OF CLINICAL ONCOLOGY

Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Central Nervous System Metastases

(2009) Brian Leyland-Jones   JOURNAL OF CLINICAL ONCOLOGY

Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation

(2009) Ho-Taek Song et al.   Journal of Translational Medicine

Epidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasis

(2009) Jeong-Eun Kim et al.   LUNG CANCER

Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis

(2009) D. Palmieri et al.   MOLECULAR CANCER RESEARCH

Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts

(2009) A. Baschnagel et al.   MOLECULAR CANCER THERAPEUTICS

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

Secreted Gaussia Luciferase as a Biomarker for Monitoring Tumor Progression and Treatment Response of Systemic Metastases

(2009) Euiheon Chung et al.   PLoS One

Activation of tumor cell integrin  v 3 controls angiogenesis and metastatic growth in the brain

(2009) M. Lorger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy

(2008) Marc-André Bellavance et al.   AAPS Journal

Re-Engineering Biopharmaceuticals for Delivery to Brain with Molecular Trojan Horses

(2008) William M. Pardridge   BIOCONJUGATE CHEMISTRY

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses

(2008) David Cameron et al.   BREAST CANCER RESEARCH AND TREATMENT

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

(2008) A Régina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Survival in patients with brain metastases from breast cancer

(2008) April F. Eichler et al.   CANCER

Development of a Preclinical Model of Spontaneous Human Melanoma Central Nervous System Metastasis

(2008) W. Cruz-Munoz et al.   CANCER RESEARCH

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

Activation of Notch Signaling in a Xenograft Model of Brain Metastasis

(2008) D.-H. Nam et al.   CLINICAL CANCER RESEARCH

Motexafin Gadolinium Combined With Prompt Whole Brain Radiotherapy Prolongs Time to Neurologic Progression in Non–Small-Cell Lung Cancer Patients With Brain Metastases: Results of a Phase III Trial

(2008) Minesh P. Mehta et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

(2008) Nancy U. Lin et al.   JOURNAL OF CLINICAL ONCOLOGY

Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival

(2008) Michelle E. Melisko et al.   JOURNAL OF NEURO-ONCOLOGY

Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain

(2008) B. Gril et al.   JNCI-Journal of the National Cancer Institute

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS