New experimental models of the blood-brain barrier for CNS drug discovery
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Title
New experimental models of the blood-brain barrier for CNS drug discovery
Authors
Keywords
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Journal
Expert Opinion on Drug Discovery
Volume 12, Issue 1, Pages 89-103
Publisher
Informa UK Limited
Online
2016-10-26
DOI
10.1080/17460441.2017.1253676
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Note: Only part of the references are listed.- Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
- (2016) María José Gómez-Lechón et al. ARCHIVES OF TOXICOLOGY
- Full biological characterization of human pluripotent stem cells will open the door to translational research
- (2016) Nina Kramer et al. ARCHIVES OF TOXICOLOGY
- In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
- (2016) Béla Z. Schmidt et al. ARCHIVES OF TOXICOLOGY
- Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis
- (2016) Shanshan Xue et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening
- (2016) Ying I. Wang et al. BIOTECHNOLOGY AND BIOENGINEERING
- Immortalized endothelial cell lines for in vitro blood–brain barrier models: A systematic review
- (2016) Nurul Adhwa Rahman et al. BRAIN RESEARCH
- Dishing out mini-brains: Current progress and future prospects in brain organoid research
- (2016) Iva Kelava et al. DEVELOPMENTAL BIOLOGY
- Pluripotent stem cell-derived kidney organoids: An in vivo-like in vitro technology
- (2016) Frans Schutgens et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mechanosensing via cell-matrix adhesions in 3D microenvironments
- (2016) Andrew D. Doyle et al. EXPERIMENTAL CELL RESEARCH
- Stem Cell Therapy for the Central Nervous System in Lysosomal Storage Diseases
- (2016) Faez Siddiqi et al. HUMAN GENE THERAPY
- In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
- (2016) Hans C Helms et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Co-culture model consisting of human brain microvascular endothelial and peripheral blood mononuclear cells
- (2016) Marianne Strazza et al. JOURNAL OF NEUROSCIENCE METHODS
- Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration
- (2016) Elodie Vandenhaute et al. LABORATORY INVESTIGATION
- Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells
- (2016) Matthew J. Stebbins et al. METHODS
- Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood–Brain Barrier Model
- (2016) Paul A. Clark et al. MOLECULAR PHARMACEUTICS
- Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines
- (2016) Aurore Drolez et al. PLoS One
- Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery
- (2016) S. Aday et al. TRENDS IN BIOTECHNOLOGY
- Printing Technologies for Medical Applications
- (2016) Ashkan Shafiee et al. TRENDS IN MOLECULAR MEDICINE
- Human induced pluripotent stem cells: A disruptive innovation
- (2016) J. De Vos et al. Current Research in Translational Medicine
- Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
- (2016) Daniel R. Bayzigitov et al. Cardiology Research and Practice
- Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
- (2016) Anna Herland et al. PLoS One
- A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces
- (2016) Vinay V. Abhyankar et al. PLoS One
- Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques
- (2016) Uma Maheswari Balaguru et al. Scientific Reports
- Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
- (2015) Jacquelyn A. Brown et al. Biomicrofluidics
- In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
- (2015) Anette Wolff et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pumpless microfluidic platform for drug testing on human skin equivalents
- (2015) Hasan Erbil Abaci et al. LAB ON A CHIP
- Organs-on-chips at the frontiers of drug discovery
- (2015) Eric W. Esch et al. NATURE REVIEWS DRUG DISCOVERY
- Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice
- (2015) Jin A. Shin et al. NEUROBIOLOGY OF AGING
- Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology
- (2015) Hansang Cho et al. Scientific Reports
- Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro
- (2015) Ravi K. Sajja et al. PLoS One
- A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes
- (2015) Louiza Bohn Thomsen et al. PLoS One
- μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips
- (2015) Peter Loskill et al. PLoS One
- Matrigel: From discovery and ECM mimicry to assays and models for cancer research
- (2014) Gabriel Benton et al. ADVANCED DRUG DELIVERY REVIEWS
- Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model
- (2014) R. Booth et al. ANNALS OF BIOMEDICAL ENGINEERING
- Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
- (2014) Rasheena Edmondson et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Two-way regulation between cells and aligned collagen fibrils: Local 3D matrix formation and accelerated neural differentiation of human decidua parietalis placental stem cells
- (2014) Wen Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Creating perfused functional vascular channels using 3D bio-printing technology
- (2014) Vivian K. Lee et al. BIOMATERIALS
- A Novel Preclinical Method to Quantitatively Evaluate Early-Stage Metastatic Events at the Murine Blood-Brain Barrier
- (2014) C. E. Adkins et al. Cancer Prevention Research
- Tissue-engineered microenvironment systems for modeling human vasculature
- (2014) Anna Tourovskaia et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain
- (2014) Imola Wilhelm et al. MOLECULAR PHARMACEUTICS
- Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro
- (2014) C. Augustine et al. NEUROSCIENCE
- In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies
- (2014) Christopher A. Palmiotti et al. PHARMACEUTICAL RESEARCH
- Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes
- (2014) Julie Boyer-Di Ponio et al. PLoS One
- A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
- (2014) Romeo Cecchelli et al. PLoS One
- In Vitro Modeling of the Neurovascular Environment by Coculturing Adult Human Brain Endothelial Cells with Human Neural Stem Cells
- (2014) Chung-Hsing Chou et al. PLoS One
- Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport
- (2014) Elizabeth E. Antoine et al. TISSUE ENGINEERING PART B-REVIEWS
- A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
- (2014) Ethan S. Lippmann et al. Scientific Reports
- Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
- (2013) Takuya Watanabe et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro
- (2013) Ke Bai et al. Biomechanics and Modeling in Mechanobiology
- A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box
- (2013) Luca Cucullo et al. BMC NEUROSCIENCE
- A detailed method for preparation of a functional and flexible blood–brain barrier model using porcine brain endothelial cells
- (2013) Adjanie Patabendige et al. BRAIN RESEARCH
- A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat
- (2013) Qiang Xue et al. International Journal of Biological Sciences
- The Wnt/Planar Cell Polarity Signaling Pathway Contributes to the Integrity of Tight Junctions in Brain Endothelial Cells
- (2013) Cédric Artus et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Isolation and expansion of human and mouse brain microvascular endothelial cells
- (2013) Stefania E Navone et al. Nature Protocols
- Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
- (2013) Roberta Paolinelli et al. PLoS One
- On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices
- (2012) Mandy Brigitte Esch et al. BIOMEDICAL MICRODEVICES
- BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
- (2012) L. M. Griep et al. BIOMEDICAL MICRODEVICES
- Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves
- (2012) Marijke De Bock et al. BRAIN RESEARCH
- Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
- (2012) J. M. Munson et al. CANCER RESEARCH
- Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes
- (2012) Ramzi Shawahna et al. CURRENT DRUG METABOLISM
- Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
- (2012) Ross Booth et al. LAB ON A CHIP
- SyM-BBB: a microfluidic blood brain barrier model
- (2012) Balabhaskar Prabhakarpandian et al. LAB ON A CHIP
- Overexpression of actin-depolymerizing factor blocks oxidized low-density lipoprotein-induced mouse brain microvascular endothelial cell barrier dysfunction
- (2012) Jun Wang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model
- (2012) Sumio Ohtsuki et al. MOLECULAR PHARMACEUTICS
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
- (2012) Ethan S Lippmann et al. NATURE BIOTECHNOLOGY
- Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models
- (2012) Eduard Urich et al. PLoS One
- In vitro microvessels for the study of angiogenesis and thrombosis
- (2012) Y. Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
- (2012) I. K. Zervantonakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of shear stress in Blood-Brain Barrier endothelial physiology
- (2011) Luca Cucullo et al. BMC NEUROSCIENCE
- Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes
- (2011) Elodie Vandenhaute et al. CURRENT NEUROVASCULAR RESEARCH
- Biomimetic tissues on a chip for drug discovery
- (2011) Amir M. Ghaemmaghami et al. DRUG DISCOVERY TODAY
- Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons
- (2011) Ethan S. Lippmann et al. JOURNAL OF NEUROCHEMISTRY
- Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models
- (2011) Kathryn Hatherell et al. JOURNAL OF NEUROSCIENCE METHODS
- In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies
- (2011) Pooja Naik et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
- (2011) Jeng-Jiann Chiu et al. PHYSIOLOGICAL REVIEWS
- Glucocorticoid Insensitivity at the Hypoxic Blood–Brain Barrier Can Be Reversed by Inhibition of the Proteasome
- (2011) Christoph Kleinschnitz et al. STROKE
- Technique for Real-Time Measurements of Endothelial Permeability in a Microfluidic Membrane Chip Using Laser-Induced Fluorescence Detection
- (2010) Edmond W. K. Young et al. ANALYTICAL CHEMISTRY
- A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells
- (2010) Nicholas Ferrell et al. BIOTECHNOLOGY AND BIOENGINEERING
- Murine in vitro model of the blood–brain barrier for evaluating drug transport
- (2010) Gilda Shayan et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System
- (2010) Luca Cucullo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Pericytes are required for blood–brain barrier integrity during embryogenesis
- (2010) Richard Daneman et al. NATURE
- Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier
- (2010) Michael J Bernas et al. Nature Protocols
- Hydrogels as extracellular matrix mimics for 3D cell culture
- (2009) Mark W. Tibbitt et al. BIOTECHNOLOGY AND BIOENGINEERING
- A microfluidic 3D hepatocyte chip for drug toxicity testing
- (2009) Yi-Chin Toh et al. LAB ON A CHIP
- Structure and function of the blood–brain barrier
- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human
- (2009) Mark S. Warren et al. PHARMACOLOGICAL RESEARCH
- Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis
- (2009) R. Daneman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
- (2008) S. Syvanen et al. DRUG METABOLISM AND DISPOSITION
- Differential effects of hydrocortisone and TNFα on tight junction proteins in anin vitromodel of the human blood-brain barrier
- (2008) Carola Förster et al. JOURNAL OF PHYSIOLOGY-LONDON
- A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
- (2008) Shinsuke Nakagawa et al. NEUROCHEMISTRY INTERNATIONAL
- Three-Dimensional Cell Culture Matrices: State of the Art
- (2008) Jungwoo Lee et al. TISSUE ENGINEERING PART B-REVIEWS
- Shear stress and 17β-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels
- (2007) Elaine Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
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