Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

Silibinin protects rat pancreatic β‐cell through up‐regulation of estrogen receptors' signaling against amylin‐ or Aβ 1–42 ‐induced reactive oxygen species/reactive nitrogen species generation

(2019) Jing Yang et al.   PHYTOTHERAPY RESEARCH

Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype

(2019) Qi Qiu et al.   Translational Neurodegeneration

Multi-Loop Model of Alzheimer Disease: An Integrated Perspective on the Wnt/GSK3β, α-Synuclein, and Type 3 Diabetes Hypotheses

(2019) Nicholas G. Norwitz et al.   Frontiers in Aging Neuroscience

High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice

(2019) Xiao-Xia Xi et al.   Frontiers in Aging Neuroscience

Catalytic Prion-Like Cross-Talk between a Key Alzheimer’s Disease Tau-Fragment R3 and the Type 2 Diabetes Peptide IAPP

(2019) Shruti Arya et al.   ACS Chemical Neuroscience

Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration

(2019) Valentina Armiento et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides

(2018) Baiping Ren et al.   ACS Chemical Neuroscience

Islet Amyloid Polypeptide Promotes Amyloid-Beta Aggregation by Binding-Induced Helix-Unfolding of the Amyloidogenic Core

(2018) Xinwei Ge et al.   ACS Chemical Neuroscience

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of protein misfolding and aggregation by natural phenolic compounds

(2018) Zohra Dhouafli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid

(2018) Qiuchen Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway

(2018) Jing Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

(2018) Nunilo Cremades et al.   NEUROBIOLOGY OF DISEASE

Amylin in Alzheimer's disease: Pathological peptide or potential treatment?

(2018) Elizabeth G. Mietlicki-Baase   NEUROPHARMACOLOGY

The action of polyphenols in Diabetes Mellitus and Alzheimer's disease: a common agent for overlapping pathologies

(2018) Ana C. Silveira et al.   Current Neuropharmacology

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

(2018) Andras Franko et al.   Scientific Reports

Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity

(2018) Yoshimitsu Kiriyama et al.   Cells

Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane

(2018) Young-Ho Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Resveratrol attenuates hIAPP amyloid formation and restores the insulin secretion ability in hIAPP-INS1 cell line via enhancing autophagy

(2018) Wu Lv et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents

(2018) Jasmin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

(2017) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

(2017) Maria Bakou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

Amylin Receptor: A Potential Therapeutic Target for Alzheimer’s Disease

(2017) Wen Fu et al.   TRENDS IN MOLECULAR MEDICINE

Unfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP)

(2017) Ivana Sequeira et al.   Nutrients

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety

(2016) Paul Velander et al.   BIOCHEMISTRY

Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development

(2016) Rebekah L Bower et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

(2016) Wei Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide

(2016) Zhi-Xue Xu et al.   Journal of Diabetes Research

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

(2016) Amit Pithadia et al.   Journal of Diabetes Research

The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats

(2016) Claudia G. Liberini et al.   Molecular Metabolism

Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition

(2016) Praveen Nedumpully-Govindan et al.   Scientific Reports

Mechanism of Inhibition of Human Islet Amyloid Polypeptide-Induced Membrane Damage by a Small Organic Fluorogen

(2016) Xiaoxu Li et al.   Scientific Reports

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

(2015) Rundong Hu et al.   ACS Chemical Neuroscience

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidine–Inhibitor Interactions

(2015) Ling-Hsien Tu et al.   BIOCHEMISTRY

Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study

(2015) Fabio Lolicato et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational insights into the inhibition and destabilization of morin on the oligomer of full-length human islet amyloid polypeptide

(2015) Qianqian Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones

(2015) Mimi Gao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress

(2015) Xiao-Lin Yu et al.   Food & Function

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Amyloid-based nanosensors and nanodevices

(2014) Charlotte A. E. Hauser et al.   CHEMICAL SOCIETY REVIEWS

Natural Compounds and Plant Extracts as Therapeutics Against Chronic Inflammation in Alzheimer’s Disease – A Translational Perspective

(2014) Nadine Apetz et al.   CNS & Neurological Disorders-Drug Targets

Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

Molecular Characterization of the Hetero-Assembly of β-Amyloid Peptide with Islet Amyloid Polypeptide

(2014) Li-Mei Yan et al.   CURRENT PHARMACEUTICAL DESIGN

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploiting the Therapeutic Potential of 8-β-d-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid β-Peptide (1–42)

(2014) Ana R. Jesus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanism of the Inhibition and Remodeling of Human Islet Amyloid Polypeptide (hIAPP1–37) Oligomer by Resveratrol from Molecular Dynamics Simulation

(2014) Qianqian Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

(2014) Sarah Srodulski et al.   Molecular Neurodegeneration

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

Exploring the Influence of EGCG on the β-Sheet-Rich Oligomers of Human Islet Amyloid Polypeptide (hIAPP1–37) and Identifying Its Possible Binding Sites from Molecular Dynamics Simulation

(2014) Qianqian Wang et al.   PLoS One

Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model

(2014) Sanda Despa et al.   Journal of the American Heart Association

In Silico Cross Seeding of Aβ and Amylin Fibril-like Oligomers

(2013) Workalemahu M. Berhanu et al.   ACS Chemical Neuroscience

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

(2013) Tayir El-Ami et al.   AGING CELL

IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-β-d-glucose

(2013) Edward Bruno et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

Oxidative Stress and Amyloid Beta Toxicity in Alzheimer’s Disease: Intervention in a Complex Relationship by Antioxidants

(2013) S. Chakrabarti et al.   CURRENT MEDICINAL CHEMISTRY

Activity of Pramlintide, Rat and Human Amylin but not Aβ1–42at Human Amylin Receptors

(2013) Joseph J. Gingell et al.   ENDOCRINOLOGY

Amylin: what might be its role in Alzheimer’s disease and how could this affect therapy?

(2013) Florin Despa et al.   Expert Review of Proteomics

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

(2013) Brittany L. Adler et al.   NEUROBIOLOGY OF AGING

Molecular links between Alzheimer’s disease and diabetes mellitus

(2013) Y. Yang et al.   NEUROSCIENCE

Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptideand protects pancreatic beta-cells against cytotoxicity

(2013) Biao Cheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

To evaluate likely antiamyloidogenic property of ferulic acid and baicalein against human islet amyloid polypeptide aggregation, in vitro Study

(2012) Seyyed Mehdi Mirhashemi   African Journal of Pharmacy and Pharmacology

Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide

(2012) Biao Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

(2012) Samuel Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Mechanism of Pancreatic Amyloid Fibril Formation: Formation of the Complex between Tea Catechins and the Fragment of Residues 22–27

(2012) Miya Kamihira-Ishijima et al.   BIOCHEMISTRY

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

(2012) Yuta Suzuki et al.   BIOCHEMISTRY

Analysis of the Inhibition and Remodeling of Islet Amyloid Polypeptide Amyloid Fibers by Flavanols

(2012) Ping Cao et al.   BIOCHEMISTRY

Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices

(2012) Takeshi Fukuda et al.   BRAIN RESEARCH

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes

(2012) Sanda Despa et al.   CIRCULATION RESEARCH

Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways

(2012) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The Polyphenol EGCG Inhibits Amyloid Formation Less Efficiently at Phospholipid Interfaces than in Bulk Solution

(2012) Maarten F. M. Engel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate food intake and energy regulation in obesity

(2012) Kiran S. Panickar   MOLECULAR NUTRITION & FOOD RESEARCH

Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

(2012) Harris Noor et al.   PROTEIN SCIENCE

Actions of β-Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

(2011) Jack H. Jhamandas et al.   AMERICAN JOURNAL OF PATHOLOGY

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

(2011) Ravichandran Ramasamy et al.   Annals of the New York Academy of Sciences

β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor

(2011) Jack H. Jhamandas et al.   APOPTOSIS

Resveratrol Inhibits the Formation of Multiple-Layered β-Sheet Oligomers of the Human Islet Amyloid Polypeptide Segment 22–27

(2011) Ping Jiang et al.   BIOPHYSICAL JOURNAL

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

(2011) Ganta V Chaitanya et al.   Journal of Neuroinflammation

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide

(2011) Nasrollah Rezaei-Ghaleh et al.   PLoS One

Progressive deterioration of insulin secretion in Japanese type 2 diabetic patients in comparison with those who carry the S20G mutation of the islet amyloid polypeptide gene: A long-term follow-up study

(2011) Shuhei Morita et al.   Journal of Diabetes Investigation

The role of amylin in the control of energy homeostasis

(2010) Thomas A. Lutz   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Cholesterol in β-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes

(2010) Liam R. Brunham et al.   Current Diabetes Reports

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

(2009) R. L. Hull et al.   DIABETOLOGIA

Fluorescence microscopy studies on islet amyloid polypeptide fibrillation at heterogeneous and cellular membrane interfaces and its inhibition by resveratrol

(2009) Diana Radovan et al.   FEBS LETTERS

Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes

(2009) Chang-jiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Elucidating the Mechanism of Lipid Membrane-Induced IAPP Fibrillogenesis and Its Inhibition by the Red Wine Compound Resveratrol: A Synchrotron X-ray Reflectivity Study

(2009) Florian Evers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS

(2008) Hila Shoval et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

(2008) Mayumi Ishikawa et al.   JOURNAL OF LIPID RESEARCH

Amyloid oligomers in diabetic and nondiabetic human pancreas

(2008) Hai-Lu Zhao et al.   Translational Research