Inhibition of protein misfolding and aggregation by natural phenolic compounds

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer’s disease

(2018) Yasir Hasan Siddique et al.   CNS & Neurological Disorders-Drug Targets

Inhibition of insulin amyloid fibrillation by Morin hydrate

(2018) Palak Patel et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid

(2018) Qiuchen Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer’s disease

(2018) Francesco Maione et al.   PHARMACOLOGICAL RESEARCH

Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates

(2018) Luana Palazzi et al.   Scientific Reports

Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

(2018) Aleksandra Maruszak et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease

(2018) David Porquet et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

(2018) Andras Franko et al.   Scientific Reports

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

(2017) Joana Loureiro et al.   MOLECULES

Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats

(2017) Rui Wang et al.   NEUROSCIENCE

Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells

(2017) Xiaping He et al.   Frontiers in Neuroscience

Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment

(2017) Theresa Köbe et al.   Frontiers in Neuroscience

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

(2016) Shigao Yang et al.   ACS Chemical Neuroscience

Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

(2016) Huy T. Lam et al.   BIOCHEMISTRY

Mechanisms for the inhibition of amyloid aggregation by small ligands

(2016) M. Ramazzotti et al.   BIOSCIENCE REPORTS

The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies

(2016) Manuela Leri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice

(2016) Ashfaq Ahmad et al.   MOLECULAR NEUROBIOLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms

(2016) Ying Du et al.   NEUROPHARMACOLOGY

Perilla frutescensvar.japonicaand rosmarinic acid improve amyloid-β25-35induced impairment of cognition and memory function

(2016) Ah Young Lee et al.   Nutrition Research and Practice

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

(2016) Amit Pithadia et al.   Journal of Diabetes Research

Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons

(2016) Wei Jiang et al.   PLoS One

Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition

(2016) Praveen Nedumpully-Govindan et al.   Scientific Reports

Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

(2016) Rutong Ren et al.   Scientific Reports

The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein

(2016) Daniela Sarnataro et al.   Scientific Reports

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

AA Amyloidosis: Pathogenesis and Targeted Therapy

(2015) Gunilla T. Westermark et al.   Annual Review of Pathology-Mechanisms of Disease

Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidine–Inhibitor Interactions

(2015) Ling-Hsien Tu et al.   BIOCHEMISTRY

Curcumin Binding to Beta Amyloid: A Computational Study

(2015) Praveen P. N. Rao et al.   Chemical Biology & Drug Design

Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study

(2015) Fabio Lolicato et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Properties of the Standardized Extract fromCamellia sinensis(Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease

(2015) Natália Bitu Pinto et al.   Evidence-based Complementary and Alternative Medicine

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

(2015) Shatadal Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of amyloid fibrillation and cytotoxicity of lysozyme fibrillation products by polyphenols

(2015) Sajad Shariatizi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Evaluation of polyphenols as possible therapeutics for amyloidoses: Comparative analysis of Kaempferol and Catechin

(2015) Waseem Feeroze Bhat et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites

(2015) Paola Florio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro Activity of Epigallocatechin Gallate and Quercetin Alone and in Combination versus Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

(2015) Jonathan W. Betts et al.   JOURNAL OF NATURAL PRODUCTS

Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

(2015) Ryoichi Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments

(2015) Yoshiki Sekijima   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Resveratrol inhibits oligomeric Aβ-induced microglial activation via NADPH oxidase

(2015) YAO YAO et al.   Molecular Medicine Reports

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

(2015) Ilaria Luccarini et al.   NEUROBIOLOGY OF AGING

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

(2015) Angélica Maria Sabogal-Guáqueta et al.   NEUROPHARMACOLOGY

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones

(2015) Mimi Gao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Transthyretin Deposition in Articular Cartilage: A Novel Mechanism in the Pathogenesis of Osteoarthritis

(2015) Yukio Akasaki et al.   Arthritis & Rheumatology

Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity

(2015) Yongjie Li et al.   Acta Pharmaceutica Sinica B

Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

(2015) Kateri J. Spinelli et al.   PLoS One

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

(2015) Wen-Jie Du et al.   Scientific Reports

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

(2015) Nuzhat Ahsan et al.   Scientific Reports

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation

(2014) Yanqin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Gallic acid, one of the components in many plant tissues, is a potential inhibitor for insulin amyloid fibril formation

(2014) Jayaraman Jayamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

(2014) Heike J. Wobst et al.   FEBS LETTERS

Pine Bark and Green Tea Concentrated Extracts: Antioxidant Activity and Comprehensive Characterization of Bioactive Compounds by HPLC–ESI-QTOF-MS

(2014) María de la Luz Cádiz-Gurrea et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myricetin Prevents Fibrillogenesis of Hen Egg White Lysozyme

(2014) Jianwei He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular Mechanism of the Inhibition and Remodeling of Human Islet Amyloid Polypeptide (hIAPP1–37) Oligomer by Resveratrol from Molecular Dynamics Simulation

(2014) Qianqian Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

(2013) Antonio Currais et al.   AGING CELL

IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-β-d-glucose

(2013) Edward Bruno et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Oxidized quercetin inhibits α-synuclein fibrillization

(2013) Min Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

(2013) Zhipeng Deng et al.   BIOMEDICAL CHROMATOGRAPHY

Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation

(2013) Yanqin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apigenin reduces human insulin fibrillation in vitro and protects SK-N-MC cells against insulin amyloids

(2013) Rahim Amini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Application of a liquid chromatography–tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats

(2013) Yanyan Jia et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats

(2013) Jia Yan-yan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of Brussels Sprouts and Their Phytochemical Components on Oxidative Stress–Induced Neuronal Damages in PC12 Cells and ICR Mice

(2013) Jae Kyeom Kim et al.   JOURNAL OF MEDICINAL FOOD

Assessment of Prospective Preventive Therapies for Chronic Wasting Disease in Mule Deer

(2013) Lisa L. Wolfe et al.   JOURNAL OF WILDLIFE DISEASES

Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model

(2013) Le Zhao et al.   MOLECULES

Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult

(2013) William I. Rosenblum   NEUROBIOLOGY OF AGING

Employing Alzheimer Disease Animal Models for Translational Research: Focus on Dietary Components

(2013) Cristina Grossi et al.   Neurodegenerative Diseases

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Agregados amiloides: rol en desórdenes de conformación proteica

(2013) Claudia Duran-Aniotz et al.   REVISTA MEDICA DE CHILE

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Natural polyphenols as modulators of TTR amyloidogenesis:in vitroandin vivoevidences towards therapy

(2012) Nelson Ferreira et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

(2012) Samuel Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Morin Inhibits the Early Stages of Amyloid β-Peptide Aggregation by Altering Tertiary and Quaternary Interactions to Produce “Off-Pathway” Structures

(2012) Justin A. Lemkul et al.   BIOCHEMISTRY

Analysis of the Inhibition and Remodeling of Islet Amyloid Polypeptide Amyloid Fibers by Flavanols

(2012) Ping Cao et al.   BIOCHEMISTRY

Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition

(2012) Nelson Ferreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine

(2012) Gerda Brunhofer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

(2012) Yong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding

(2012) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The binding of resveratrol to monomer and fibril amyloid beta

(2012) Jin-Fang Ge et al.   NEUROCHEMISTRY INTERNATIONAL

Misfolded PrP and a novel mechanism of proteasome inhibition

(2012) Ralph Andre et al.   Prion

Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

(2012) Harris Noor et al.   PROTEIN SCIENCE

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Biflavonoids Are Superior to Monoflavonoids in Inhibiting Amyloid-β Toxicity and Fibrillogenesis via Accumulation of Nontoxic Oligomer-like Structures

(2011) Arjun Thapa et al.   BIOCHEMISTRY

Resveratrol Inhibits the Formation of Multiple-Layered β-Sheet Oligomers of the Human Islet Amyloid Polypeptide Segment 22–27

(2011) Ping Jiang et al.   BIOPHYSICAL JOURNAL

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

(2011) Stefania Rigacci et al.   Current Alzheimer Research

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats

(2011) Akari Ishisaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apigenin Isolated from the Medicinal Plant Elsholtzia rugulosa Prevents β-Amyloid 25–35-Induces Toxicity in Rat Cerebral Microvascular Endothelial Cells

(2011) Le Zhao et al.   MOLECULES

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y Cells

(2011) Zhengrong Mei et al.   NEUROCHEMICAL RESEARCH

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation

(2011) Tai-Chun Huang et al.   PLoS One

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

(2011) Ines Moreno-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rapid cell-surface prion protein conversion revealed using a novel cell system

(2011) R. Goold et al.   Nature Communications

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease

(2010) Daijiro Yanagisawa et al.   BIOMATERIALS

Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy

(2010) Petros A. Galanakis et al.   BIOPOLYMERS

Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice

(2010) Jae Kyeom KIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

(2010) Pamela Maher et al.   HUMAN MOLECULAR GENETICS

Bioavailability of the Polyphenols: Status and Controversies

(2010) Massimo D’Archivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide

(2010) Lei Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

(2010) R. Morales et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Bioavailability of dietary flavonoids and phenolic compounds

(2010) Alan Crozier et al.   MOLECULAR ASPECTS OF MEDICINE

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

A traditional medicinal herbPaeonia suffruticosaand its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteinsin vitroandin vivo

(2009) Hironori Fujiwara et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

(2009) Jason Pitt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

Curcumin inhibits aggregation of α-synuclein

(2008) Neeraj Pandey et al.   ACTA NEUROPATHOLOGICA

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

(2008) Tatsuhiro Akaishi et al.   NEUROSCIENCE LETTERS