Article
Multidisciplinary Sciences
Anoj Ilanges, Rani Shiao, Jordan Shaked, Ji-Dung Luo, Xiaofei Yu, Jeffrey M. Friedman
Summary: This study reveals the neural mechanisms underlying sickness behaviors induced by infection, showing that a specific subpopulation of neurons in the brainstem can control these responses. It establishes a critical link between the brain and the response to infection.
Article
Pharmacology & Pharmacy
Salome Gamakharia, Christelle Le Foll, Wolfgang Rist, Tamara Baader-Pagler, Angela Baljuls, Thomas A. Lutz
Summary: The anorectic action of amylin is mainly mediated through the area postrema (AP). The long-acting amylin analogue (LAAMA) exerted effects on body weight gain through the CTR receptor, but was not effective in producing weight loss and appetite suppression without specific AMY receptor.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Bartkowska, Krzysztof Turlejski, Beata Tepper, Leszek Rychlik, Peter Vogel, Ruzanna Djavadian
Summary: The study found that different species of shrews have similar density of newly generated cells in the brain, but the rate of adult neurogenesis in different structures varies, suggesting that brain size does not affect the number of newly generated neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Maria Sidorova, Golo Kronenberg, Susann Matthes, Markus Petermann, Rainer Hellweg, Oksana Tuchina, Michael Bader, Natalia Alenina, Friederike Klempin
Summary: The study utilized a new transgenic rat model to investigate the effects of changes in 5-HT levels, and found that alterations in 5-HT concentrations in different brain regions can trigger diverse physiological and behavioral responses, which may represent a compensatory mechanism.
Article
Biology
Kent D. Dunlap, Magda C. Teles, Rui F. Oliveira
Summary: Research indicates that cells born in the adult zebrafish brain are sensitive to social stimuli and may play a role in regulating social behavior. This suggests that adult neurogenesis in fish may contribute to behavioral plasticity, with cells being able to respond to external cues and potentially drive changes in behavior.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Julia Mehlhorn, Nelson Niski, Ke Liu, Svenja Caspers, Katrin Amunts, Christina Herold
Summary: This study provides a comprehensive and in-depth qualitative and quantitative analysis of different stages of adult neurogenesis in the brain of adult homing pigeons, revealing an uneven distribution of adult newborn neurons and glia, with the highest numbers found in the intercalated hyperpallium and the hippocampal formation.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Neurosciences
Katarzyna Bartkowska, Krzysztof Turlejski, Paulina Koguc-Sobolewska, Ruzanna Djavadian
Summary: In mammals, adult neurogenesis has been observed in several brain structures, including the subventricular zone of the lateral ventricle and the dentate gyrus of the hippocampal formation. However, the origin of newly generated cells in other structures, such as the striatum, amygdala, and hypothalamus, remains unclear.
Article
Biochemistry & Molecular Biology
Stephanie Dumontoy, Bahrie Ramadan, Pierre-Yves Risold, Solene Pedron, Christophe Houdayer, Adeline Etievant, Lidia Cabeza, Emmanuel Haffen, Yvan Peterschmitt, Vincent Van Waes
Summary: Repeated anodal transcranial direct current stimulation (RA-tDCS) is a neuromodulatory technique that can improve memory and have antidepressant-like effects. This study aimed to evaluate the impact of RA-tDCS on hippocampal neurogenesis levels in mice. The results showed that RA-tDCS increased cell proliferation in young adult female mice, but had no effect on cell survival. No modulation of cell proliferation or survival was observed in middle-aged animals or male mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Wei-Yi Ong, R. L. Satish, Deron R. Herr
Summary: SARS-CoV-2 can enter cells by binding to ACE2, and it may enter the brain through circumventricular organs and the hypothalamus. Binding of the virus with ACE2 could lead to a reduction in the ACE2 / Ang (1-7) / Mas receptor signaling pathway, affecting neural activity and the hypothalamic-pituitary-adrenal axis. The virus may also affect the hypothalamus via transneuronal spread along olfactory/limbic pathways. Exploring potential therapeutic pathways to prevent or reduce neurological symptoms of COVID-19 is important.
NEUROMOLECULAR MEDICINE
(2022)
Article
Veterinary Sciences
Mahmoud Dahab, Cyrine Ben-Dhaou, Maeva Cherif-Feildel, Marie Moftah, Hussein Khamis Hussein, Emmanuel Moyse, Sherine Abdel Salam
Summary: This study directly addresses the existence of neural stem cells in the neurogenic niche of the vagal centre in adult ovine mammals. The findings show the formation of expandable and self-renewing spheres in the neurogenic niche, as well as differences in the expression of specific markers compared to other neurogenic regions. This discovery has important implications for understanding the dynamics of adult mammalian neurogenesis and corresponding features in other species.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Sandra Ledesma-Corvi, M. Julia Garcia-Fuster
Summary: The study investigated the effects of electroconvulsive therapy (ECT) on neuroplasticity markers in the hippocampus of rats. It found sex- and age-differences in the response to ECT, and identified persistent molecular changes induced by ECT in the hippocampus of both males and females, especially in adolescence. These findings suggest the need for further exploration of the underlying reasons for the disparities and the development of personalized treatments for each sex.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Chuchu Zhang, Judith A. Kaye, Zerong Cai, Yandan Wang, Sara L. Prescott, Stephen D. Liberles
Summary: By constructing an area postrema cell atlas and utilizing cell-specific manipulation, the basic organization of the area postrema nausea circuitry has been revealed, providing a framework for further exploration of nausea mechanisms.
Article
Neurosciences
Cyrine Ben Dhaou, Elodie Terrie, Nadine Deliot, Thomas Harnois, Laetitia Cousin, Patricia Arnault, Bruno Constantin, Emmanuel Moyse, Valerie Coronas
Summary: Neural stem cells (NSCs) in specific brain regions play a crucial role in maintaining neurogenesis. The area postrema in the brainstem has been found to be a neurogenic zone as well. This study investigated the presence and function of store-operated Ca2+ channels (SOCs) in NSCs derived from the area postrema. The results showed that NSCs expressed TRPC1 and Orai1, known to form SOCs, and their activator STIM1. Inhibition of SOCs led to decreased NSC proliferation and self-renewal, while leptin, an adipose tissue-derived hormone, also affected SOCEs and NSC activity in the area postrema.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Fabian Johannes Pflieger, Jacqueline Wolf, Martin Feldotto, Andreas Nockher, Tatjana Wenderoth, Jessica Hernandez, Joachim Roth, Daniela Ott, Christoph Rummel
Summary: This study investigated the potential of sensory circumventricular organs (sCVOs) to produce n-3 and n-6 oxylipins after lipopolysaccharide (LPS) stimulation. The results showed that LPS stimulation increased the release of cytokines and certain oxylipins. However, co-treatment with norepinephrine (NE) did not significantly alter the levels of oxylipins or the changes in TNF alpha levels. These findings suggest that LPS-induced oxylipins may play an important role in immune-to-brain communication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jin Kwon Jeong, Samantha A. Dow, Colin N. Young
Summary: The central nervous system plays a critical role in metabolic regulation, with evidence suggesting a distributed network of brain regions involved in energy homeostasis. Circumventricular organs (CVOs) are emerging as potential sites for circulating metabolic substances to influence neuroendocrine control, potentially playing an important role in energy homeostasis.
Article
Psychology, Biological
Lynda Whiting, James E. McCutcheon, Christina N. Boyle, Mitchell F. Roitman, Thomas A. Lutz
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll
Article
Biochemical Research Methods
Philippe J. Eugster, Christina N. Boyle, Sylvain Prod'hom, Erika Tarasco, Thierry Buclin, Thomas A. Lutz, Alan G. Harris, Eric Grouzmann
DRUG TESTING AND ANALYSIS
(2018)
Review
Endocrinology & Metabolism
Christina Neuner Boyle, Thomas Alexander Lutz, Christelle Le Foll
MOLECULAR METABOLISM
(2018)
Article
Physiology
Sonya Duffy, Thomas A. Lutz, Christina N. Boyle
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Article
Physiology
Seraina S. Senn, Christelle Le Foll, Lynda Whiting, Erika Tarasco, Sonya Duffy, Thomas A. Lutz, Christina Neuner Boyle
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Erika Tarasco, Christina N. Boyle, Giovanni Pellegrini, Myrtha Arnold, Regula Steiner, Thorsten Hornemann, Dimitris Nasias, Dimitris Kardassis, Lynda Whiting, Thomas A. Lutz
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Review
Neurosciences
Christina N. Boyle, Christelle Le Foll
Article
Neurosciences
Bernd Coester, Sydney W. Pence, Soraya Arrigoni, Christina N. Boyle, Christelle Le Foll, Thomas A. Lutz
Article
Immunology
Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Article
Endocrinology & Metabolism
Simone Carneiro-Nascimento, Jolanta Opacka-Juffry, Adele Costabile, Christina N. Boyle, Adrienne Mueller Herde, Simon M. Ametamey, Hannes Sigrist, Christopher R. Pryce, Michael Patterson
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Psychology, Biological
Miriam Honegger, Thomas A. Lutz, Christina N. Boyle
Summary: The ability of amylin to inhibit food intake is reduced under hypoglycemic conditions, possibly due to the co-sensitivity of AP neurons to amylin and glucose. Amylin can also buffer meal-induced glucose appearance at EU and HYPO levels.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monne Rodriguez, Julia Guenter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Summary: Dysregulated energy metabolism is a major cause of various diseases. OTUB1 plays an important regulatory role in energy metabolism. Deletion of OTUB1 in mice leads to increased energy expenditure and improved glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Christina N. Boyle, Yi Zheng, Thomas A. Lutz
Summary: Amylin, a pancreatic beta-cell hormone, plays important physiological roles in metabolic control, such as regulating satiation, gastric emptying, and glucagon secretion. Amylin analogs have emerged as promising approaches for obesity and diabetes treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F. Daly, Philippe J. Eugster, Alan G. Harris, Eric Grouzmann, Thomas A. Lutz, Christina N. Boyle
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)