Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity

Impact of membrane curvature on amyloid aggregation

(2018) Mayu S. Terakawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

(2018) Miriam García Hernández et al.   Cell Death & Disease

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

(2018) Melissa Birol et al.   Nature Communications

Adjunctive therapy for glucose control in patients with type 1 diabetes

(2018) Kira Harris et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment

(2017) Joel Montane et al.   FASEB JOURNAL

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glucoregulatory actions of leptin

(2017) Anna M. D'souza et al.   Molecular Metabolism

Transcribing β-cell mitochondria in health and disease

(2017) Hindrik Mulder   Molecular Metabolism

Intra- and Intercellular Quality Control Mechanisms of Mitochondria

(2017) et al.   Cells

Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics

(2017) Ashim Paul et al.   Scientific Reports

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

(2016) Debbie L. Hay et al.   Annual Review of Pharmacology and Toxicology

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

(2016) Clara Iannuzzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

(2016) Daniel T. Meier et al.   DIABETOLOGIA

Foldamer-mediated manipulation of a pre-amyloid toxin

(2016) Sunil Kumar et al.   Nature Communications

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake

(2015) Elizabeth G. Mietlicki-Baase et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling and proliferation

(2015) Montse Visa et al.   FASEB JOURNAL

The Function of Autophagy in Neurodegenerative Diseases

(2015) Yoshimitsu Kiriyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha-, Delta- and PP-cells

(2015) Melissa F. Brereton et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones

(2015) Mimi Gao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration

(2015) Praveen Nedumpully-Govindan et al.   Scientific Reports

Distribution of insulin mRNA transcripts within the human body

(2014) Glenn D. Bell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amylin-Induced Central IL-6 Production Enhances Ventromedial Hypothalamic Leptin Signaling

(2014) Christelle Le Foll et al.   DIABETES

Ghrelin signalling inβ-cells regulates insulin secretion and blood glucose

(2014) T. Yada et al.   DIABETES OBESITY & METABOLISM

Platelet-Activating Factor Mediates the Cytotoxicity Induced by W7FW14F Apomyoglobin Amyloid Aggregates in Neuroblastoma Cells

(2014) Ivana Sirangelo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

pH Dependence of Amylin Fibrillization

(2013) Suman Jha et al.   BIOCHEMISTRY

Effect of Proline Mutations on the Monomer Conformations of Amylin

(2013) Chi-cheng Chiu et al.   BIOPHYSICAL JOURNAL

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

(2013) Aseem Mishra et al.   CHEMICAL COMMUNICATIONS

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

(2013) Elizabeth G Mietlicki-Baase et al.   NEUROPSYCHOPHARMACOLOGY

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

The Effect of Aβ on IAPP Aggregation in the Presence of an Isolated β-Cell Membrane

(2012) Janine Seeliger et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fibril Structure of Human Islet Amyloid Polypeptide

(2011) Sahar Bedrood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure

(2011) Lu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Human pro-islet amyloid polypeptide (ProIAPP1–48) forms amyloid fibrils and amyloid spherulites in vitro

(2010) Christopher Exley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Fatty acids induce amylin expression and secretion by pancreatic β-cells

(2009) Dongfei Qi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of Amylin/Leptin Synergy in Rodent Models

(2009) Victoria F. Turek et al.   ENDOCRINOLOGY

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Dehydrophenylalanine (ΔPhe) as a β Breaker: Extended Structure Terminated by a ΔPhe-Induced Turn in the Pentapeptide Boc-Phe1-Ala2-Ile3-ΔPhe4-Ala5-OMe

(2008) Madhvi Gupta et al.   CHEMBIOCHEM

Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide

(2008) H. J. Woerle et al.   DIABETES CARE

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

(2008) J. D. Roth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

(2008) Jed J.W. Wiltzius et al.   PROTEIN SCIENCE