Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease

KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor to Abate Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine

(2020) Md. Tanvir Kabir et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Combination Drug Therapy for the Management of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   MOLECULES

Novel Anti-Alzheimer’s Therapeutic Molecules Targeting Amyloid Precursor Protein Processing

(2020) Md. Sahab Uddin et al.   Oxidative Medicine and Cellular Longevity

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   Oxidative Medicine and Cellular Longevity

Circadian and sleep dysfunction in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

(2020) Seetha Harilal et al.   BRAIN RESEARCH BULLETIN

Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration

(2020) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK

(2019) Md. Sahab Uddin et al.   NEUROTOXICITY RESEARCH

Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives

(2019) Seetha Harilal et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases

(2019) Bijo Mathew et al.   ARCHIV DER PHARMAZIE

Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function

(2019) Shigehiko Ogoh et al.   Journal of Physiological Sciences

Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest

(2019) Md. Sahab Uddin et al.   Frontiers in Cell and Developmental Biology

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review

(2018) Candice E. Van Skike et al.   GERONTOLOGY

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Interplay Between Age, Cerebral Small Vessel Disease, Parenchymal Amyloid-β, and Tau Pathology: Longitudinal Studies in Hypertensive Stroke-Prone Rats

(2018) Stefanie Schreiber et al.   JOURNAL OF ALZHEIMERS DISEASE

Analyzing the chance of developing dementia among geriatric people: a cross-sectional pilot study in Bangladesh

(2018) Md. Sahab Uddin et al.   Psychogeriatrics

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

(2017) Stefano Tarantini et al.   EXPERIMENTAL GERONTOLOGY

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

(2017) Cátia F. Lourenço et al.   EXPERIMENTAL NEUROLOGY

An endothelial link between the benefits of physical exercise in dementia

(2017) Lianne J Trigiani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

(2017) Jordan B Jahrling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson’s disease

(2017) Zoe Joanna Syrimi et al.   JOURNAL OF NEURAL TRANSMISSION

A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

(2017) Hendrik Wesseling et al.   Molecular Autism

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies

(2017) Diana L Castillo-Carranza et al.   Aging and Disease

Cerebrovascular Hypoperfusion Induces Spatial Memory Impairment, Synaptic Changes, and Amyloid-β Oligomerization in Rats

(2017) Xiaojuan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer’s DiseaseNovelty and Significance

(2016) Susan A. Austin et al.   CIRCULATION RESEARCH

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

(2016) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

(2015) Sana Suri et al.   Alzheimers & Dementia

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen–glucose deprivation and reoxygenation

(2015) Chun-Yu Li et al.   NEUROCHEMISTRY INTERNATIONAL

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.

(2015) Alessandro Bitto et al.   Cold Spring Harbor Perspectives in Medicine

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

(2014) Alfred J. Meijer et al.   AMINO ACIDS

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Distinct perfusion patterns in Alzheimer’s disease, frontotemporal dementia and dementia with Lewy bodies

(2014) Maja A. A. Binnewijzend et al.   EUROPEAN RADIOLOGY

Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats

(2014) Wei Guo et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells

(2014) Borzo Gharibi et al.   STEM CELLS

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

(2014) Haiying Li et al.   Translational Stroke Research

GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine

(2014) Tyler Mark Pierson et al.   Annals of Clinical and Translational Neurology

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice

(2013) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Review article What causes alzheimer’s disease?

(2013) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A recollection of mTOR signaling in learning and memory

(2013) T. E. Graber et al.   LEARNING & MEMORY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain

(2013) Sujuan Chen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Impaired Neurovascular Coupling in the APPxPS1 Mouse Model of Alzheimer’s Disease

(2012) Armelle Rancillac et al.   Current Alzheimer Research

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease

(2012) Gunnar K. Gouras   JOURNAL OF NEUROCHEMISTRY

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

mTOR-Dependent Cell Survival Mechanisms

(2012) C.-M. Hung et al.   Cold Spring Harbor Perspectives in Biology

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive dysfunction with aging and the role of inflammation

(2011) Arthur A. Simen et al.   Therapeutic Advances in Chronic Disease

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls

(2009) S. Fossati et al.   FASEB JOURNAL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Forskolin induction of late-LTP and up-regulation of 5 TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

(2008) Delphine Gobert et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice

(2008) M. D. Antion et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE