Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology

Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial

(2018) Charoonsri Chusak et al.   BMC Complementary and Alternative Medicine

Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2018) Rebecca Power et al.   JOURNAL OF ALZHEIMERS DISEASE

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer’s disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions

(2018) Talita Elisa Berté et al.   STEROIDS

Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFα induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation

(2018) Sivasankar Shanmuganathan et al.   VASCULAR PHARMACOLOGY

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Neuroprotective effect of Asparagus racemosus root extract via the enhancement of brain-derived neurotrophic factor and estrogen receptor in ovariectomized rats

(2018) Laddawan Lalert et al.   JOURNAL OF ETHNOPHARMACOLOGY

Analyzing the chance of developing dementia among geriatric people: a cross-sectional pilot study in Bangladesh

(2018) Md. Sahab Uddin et al.   Psychogeriatrics

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes

(2017) Yuting Ling et al.   Oncotarget

Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

(2017) Muhammad Ayaz et al.   Frontiers in Pharmacology

Neuroprotective Roles of l-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats

(2017) Tong Li et al.   Frontiers in Neurology

Gotu Kola (Centella Asiatica) Extract Enhances Phosphorylation of Cyclic AMP Response Element Binding Protein in Neuroblastoma Cells Expressing Amyloid Beta Peptide

(2017) Yanan Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Nanocapsulated Ascorbic Acid in Combating Cerebral Ischemia Reperfusion- Induced Oxidative Injury in Rat Brain

(2016) Sibani Sarkar et al.   Current Alzheimer Research

Protective Role of Quercetin in Cadmium-Induced Cholinergic Dysfunctions in Rat Brain by Modulating Mitochondrial Integrity and MAP Kinase Signaling

(2016) Richa Gupta et al.   MOLECULAR NEUROBIOLOGY

Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats

(2016) Zhiqiang Wang et al.   NEUROSCIENCE LETTERS

Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats

(2016) Tzu Yu Lin et al.   NEUROTOXICOLOGY

Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation

(2016) Yoonjung Lee et al.   Scientific Reports

Therapies for Prevention and Treatment of Alzheimer’s Disease

(2016) J. Mendiola-Precoma et al.   Biomed Research International

Neuroprotective response of the hippocampus region of the brain to Withania somnifera and Asparagus racemosus root extract: An in vitro study

(2016) Bhatnagar Maheep et al.   Journal of Medicinal Plants Research

Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation

(2016) Kalaivani Batumalaie et al.   Scientific Reports

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease

(2015) Ahmed Moneim   Current Alzheimer Research

Protective Role of Ternatin Anthocyanins and Quercetin Glycosides from Butterfly Pea (Clitoria ternatea Leguminosae) Blue Flower Petals against Lipopolysaccharide (LPS)-Induced Inflammation in Macrophage Cells

(2015) Vimal Nair et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury

(2015) Yaghoob Farbood et al.   LIFE SCIENCES

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

(2015) XIAOMING LEI et al.   Molecular Medicine Reports

Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?

(2015) Chunyan Xue et al.   Journal of Ophthalmology

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

(2014) Hee Ju Kim et al.   Biomolecules & Therapeutics

Comparing the efficacy and safety ofCrocus sativusL. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial

(2014) Mehdi Farokhnia et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Evaluation of the Neuroprotective Effects of Centella asiatica Against Scopolamine Induced Cognitive Impairment in Mice

(2014) Sunandha Bhumireddy Papireddy Venkata et al.   Indian Journal of Pharmaceutical Education and Research

A Review on the Pharmacological Aspects of Terminalia chebula

(2014) D.K. Singh et al.   International Journal of Pharmacology

Neuroprotective effects of Asiaticoside

(2014) Shui-bing Liu et al.   Neural Regeneration Research

Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer’s Disease

(2014) Dong-Mei Wang et al.   NEUROCHEMICAL RESEARCH

In Vitro Screening for Anti-Cholinesterase and Antioxidant Activity of Methanolic Extracts of Ayurvedic Medicinal Plants Used for Cognitive Disorders

(2014) Maya Mathew et al.   PLoS One

Spectroscopic studies on the antioxidant activity of ellagic acid

(2014) Ismail Kilic et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma

(2014) Rasha H. Hussein et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease

(2013) Shereen K Ali et al.   BMC Complementary and Alternative Medicine

The Case for Anthocyanin Consumption to Promote Human Health: A Review

(2013) Elisa Pojer et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

(2013) Ana Murray et al.   Current Neuropharmacology

Rutin: therapeutic potential and recent advances in drug delivery

(2013) Shrestha Sharma et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats

(2013) Chang-Liang Xu et al.   FITOTERAPIA

Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats

(2013) Atish Prakash et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Ascorbic acid glucoside reduces neurotoxicity and glutathione depletion in mouse brain induced by nitrotriazole radiosensitazer

(2013) NadezdaV Cherdyntseva et al.   Journal of Cancer Research and Therapeutics

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

(2013) Kesava Rao Venkata Kurapati et al.   PLoS One

Spectroscopic studies on the antioxidant activity of p-coumaric acid

(2013) Ismail Kiliç et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

(2013) R. Tarawneh et al.   Cold Spring Harbor Perspectives in Medicine

Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model

(2012) Le Zhao et al.   BRAIN RESEARCH

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

(2012) Xiangnan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment

(2012) Zacharoula I. Linardaki et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of d-friedoolean-13-en-3-one (Taraxerone) as an antioxidant compound from sedom (Sedum sarmentosum)

(2012) Eun Kyoung Mo et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Antioxidant Activity of Isolated Ellagitannins from Red Raspberries and Cloudberries

(2012) Marja Kähkönen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Saffron as a Source of Novel Acetylcholinesterase Inhibitors: Molecular Docking and in Vitro Enzymatic Studies

(2012) George D. Geromichalos et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

l-Ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme oxygenase-1

(2012) Ya-Ni Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection

(2011) Magdalini A. Papandreou et al.   BEHAVIOURAL BRAIN RESEARCH

Protective Effect of Chlorogenic Acid against Aβ-Induced Neurotoxicity

(2011) Chan-Woo Lee et al.   Biomolecules & Therapeutics

Inhibition kinetics of certain enzymes in the nervous tissue of vector snail Lymnaea acuminata by active molluscicidal components of Sapindus mukorossi and Terminalia chebula

(2011) Aparna Upadhyay et al.   CHEMOSPHERE

Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats

(2011) Behshid Ghadrdoost et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of motor function in preclinical Alzheimer’s disease

(2011) Aron S Buchman et al.   Expert Review of Neurotherapeutics

Enhancement of Dissolution and Antioxidant Activity of Kaempferol Using a Nanoparticle Engineering Process

(2011) Cheng-Wei Tzeng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

No Significant Effect of Ginkgo Biloba Special Extract EGb 761 in the Treatment of Primary Raynaud Phenomenon

(2011) Sebastian J. H. Bredie et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Nootropic, anxiolytic and CNS-depressant studies on different plant sources ofshankhpushpi

(2011) Jai Malik et al.   PHARMACEUTICAL BIOLOGY

Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax

(2011) Chang-Liang Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity

(2011) M.N. Nasir et al.   PHYTOMEDICINE

Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats

(2011) Hossein Hosseinzadeh et al.   PHYTOTHERAPY RESEARCH

Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid

(2011) María-Salud García-Ayllón   Frontiers in Molecular Neuroscience

Effects of asiatic acid on passive and active avoidance task in male Spraque–Dawley rats

(2010) M.N. Nasir et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae

(2010) Siddharthan Surveswaran et al.   NATURAL PRODUCT RESEARCH

Short-term memory binding deficits in Alzheimer's disease

(2009) M. A. Parra et al.   BRAIN

Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET

(2009) Chihiro Tohda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Withanamides inWithania somniferafruit protect PC-12 cells from β-amyloid responsible for Alzheimer's disease

(2009) Bolleddula Jayaprakasam et al.   PHYTOTHERAPY RESEARCH

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

(2009) Shahin Akhondzadeh et al.   PSYCHOPHARMACOLOGY

1,2,3,4,6-penta-O-galloyl-β-d-glucose: A cholinesterase inhibitor from Terminalia chebula

(2009) S. Sancheti et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells

(2009) Jing-Ting Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury

(2008) Yongjin Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Molecular Structure and Antioxidant Properties of Delphinidin

(2008) Laura Estévez et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

(2008) Gjumrakch Aliev et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

(2008) S. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica

(2007) Jintanaporn Wattanathorn et al.   JOURNAL OF ETHNOPHARMACOLOGY