Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells

How to track cellular aging of mesenchymal stromal cells?

(2016) Wolfgang Wagner et al.   Aging-US

Mechanisms that Regulate Stem Cell Aging and Life Span

(2013) Robert A.J. Signer et al.   Cell Stem Cell

Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading

(2013) Daichi Morikawa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

(2013) Jiezhong Chen et al.   TISSUE ENGINEERING PART B-REVIEWS

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal

(2012) Borzo Gharibi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oct4 and Nanog Directly Regulate Dnmt1 to Maintain Self-Renewal and Undifferentiated State in Mesenchymal Stem Cells

(2012) Chih-Chien Tsai et al.   MOLECULAR CELL

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential

(2012) Juhee Han et al.   STEM CELLS

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

(2012) Siddaraju V. Boregowda et al.   STEM CELLS

Effects of Medium Supplements on Proliferation, Differentiation Potential, and In Vitro Expansion of Mesenchymal Stem Cells

(2012) Borzo Gharibi et al.   Stem Cells Translational Medicine

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

mTORC1 signaling governs hematopoietic stem cell quiescence

(2011) Boyi Gan et al.   CELL CYCLE

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

(2011) Ryan C. Russell et al.   DEVELOPMENT

Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes

(2011) Borzo Gharibi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

(2011) Hidetoshi Nojiri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

(2011) R. Somwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow

(2010) Ji Min Yu et al.   AGING CELL

Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout mice

(2010) Michael J. Smietana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

(2010) C.-C. Tsai et al.   BLOOD

Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1

(2010) Robin M. Hobbs et al.   CELL

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Different Facets of Aging in Human Mesenchymal Stem Cells

(2010) Wolfgang Wagner et al.   TISSUE ENGINEERING PART B-REVIEWS

Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

(2009) Ilaria Bellantuono et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

(2009) Rogerio M. Castilho et al.   Cell Stem Cell

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

(2009) Hugo Alves et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

(2009) Wolfgang Wagner et al.   PLoS One

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

(2009) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

(2008) Shuanhu Zhou et al.   AGING CELL

Bone and fat connection in aging bone

(2008) Gustavo Duque   CURRENT OPINION IN RHEUMATOLOGY

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES