An endothelial link between the benefits of physical exercise in dementia

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

(2016) Makoto Ishii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer’s DiseaseNovelty and Significance

(2016) Susan A. Austin et al.   CIRCULATION RESEARCH

The Disconnection Hypothesis in Alzheimer’s Disease Studied Through Multimodal Magnetic Resonance Imaging: Structural, Perfusion, and Diffusion Tensor Imaging

(2016) María Lacalle-Aurioles et al.   JOURNAL OF ALZHEIMERS DISEASE

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

The role of the Wnt canonical signaling in neurodegenerative diseases

(2016) Rosaliana Libro et al.   LIFE SCIENCES

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System

(2016) Christos Koutsakis et al.   Frontiers in Cellular Neuroscience

Imaging of Leukocyte Trafficking in Alzheimer’s Disease

(2016) Enrica Pietronigro et al.   Frontiers in Immunology

The Effects of Aerobic Exercise on Cognitive Function of Alzheimer’s Disease Patients

(2015) Si-Yu Yang et al.   CNS & Neurological Disorders-Drug Targets

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

(2015) Thierry Paillard et al.   Journal of Clinical Neurology

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

(2015) N. Miyamoto et al.   JOURNAL OF NEUROSCIENCE

Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

(2015) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

White matter hyperintensities, cognitive impairment and dementia: an update

(2015) Niels D. Prins et al.   Nature Reviews Neurology

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

(2015) Luigi Yuri Di Marco et al.   NEUROBIOLOGY OF DISEASE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Effects of Physical Activity Training in Patients with Alzheimer’s Dementia: Results of a Pilot RCT Study

(2015) Vjera A. Holthoff et al.   PLoS One

Vascular function, insulin action, and exercise: an intricate interplay

(2015) Chao Zheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?

(2015) Melanie Meyer-Luehmann et al.   TRENDS IN NEUROSCIENCES

Sleep, Cognition and Dementia

(2015) Verna R. Porter et al.   Current Psychiatry Reports

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats

(2014) N Uysal et al.   BIOTECHNIC & HISTOCHEMISTRY

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

(2014) I.R. Macdonald et al.   Current Alzheimer Research

Aerobic fitness is associated with greater white matter integrity in children

(2014) Laura Chaddock-Heyman et al.   Frontiers in Human Neuroscience

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Connections between sleep and cognition in older adults

(2014) Kristine Yaffe et al.   LANCET NEUROLOGY

Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer’s Disease

(2014) An T. Dao et al.   MOLECULAR NEUROBIOLOGY

Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice

(2014) Odochi Ohia-Nwoko et al.   Molecular Neurodegeneration

Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis

(2014) Jin Lee et al.   Nutrition Research and Practice

Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

(2014) Hai Bo et al.   Oxidative Medicine and Cellular Longevity

Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms

(2014) Yoelvis García-Mesa et al.   PSYCHONEUROENDOCRINOLOGY

Brain White Matter Tracts: Functional Anatomy and Clinical Relevance

(2014) Amy C. Gerrish et al.   SEMINARS IN ULTRASOUND CT AND MRI

Features of Cerebral Autosomal Recessive Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

(2014) Hiroaki Nozaki et al.   STROKE

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS

(2014) Sheepsumon Viboolvorakul et al.   Biomed Research International

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

Mitochondria, endothelial cell function, and vascular diseases

(2014) Xiaoqiang Tang et al.   Frontiers in Physiology

Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice

(2013) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular Aspects of Cognitive Impairment and Dementia

(2013) Maximilian Wiesmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early exercise improves cerebral blood flow through increased angiogenesis in experimental stroke rat model

(2013) Pengyue Zhang et al.   Journal of NeuroEngineering and Rehabilitation

Enfermedad de Alzheimer y deterioro cognitivo asociado a la diabetes mellitus de tipo 2: relaciones e hipótesis

(2013) R.O. Domínguez et al.   NEUROLOGIA

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Decreased serum levels of the angiogenic factors VEGF and TGF-β1 in Alzheimer's disease and amnestic mild cognitive impairment

(2013) Li Huang et al.   NEUROSCIENCE LETTERS

Neuroprotective Effect of Physical Exercise in a Mouse Model of Alzheimer’s Disease Induced by β-Amyloid1–40 Peptide

(2013) Leandro C. Souza et al.   NEUROTOXICITY RESEARCH

New Insights into the Dementia Epidemic

(2013) Eric B. Larson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucose Metabolism during Resting State Reveals Abnormal Brain Networks Organization in the Alzheimer’s Disease and Mild Cognitive Impairment

(2013) Gretel Sanabria-Diaz et al.   PLoS One

Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

White matter connectivity and aerobic fitness in male adolescents

(2013) Megan M. Herting et al.   Developmental Cognitive Neuroscience

Pathology and pathogenesis of vascular cognitive impairment—a critical update

(2013) Kurt A. Jellinger   Frontiers in Aging Neuroscience

Epidemiological of and risk factors for Alzheimer's disease: A review

(2012) Jana Povova et al.   BIOMEDICAL PAPERS-OLOMOUC

Effect of age on exercise-induced alterations in cognitive executive function: Relationship to cerebral perfusion

(2012) Samuel J.E. Lucas et al.   EXPERIMENTAL GERONTOLOGY

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

Endothelin 1–Dependent Neurovascular Dysfunction in Chronic Intermittent Hypoxia

(2012) Carmen Capone et al.   HYPERTENSION

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer’s disease?

(2012) B M Brown et al.   MOLECULAR PSYCHIATRY

The importance of the endothelium in atherothrombosis and coronary stenting

(2012) Fumiyuki Otsuka et al.   Nature Reviews Cardiology

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1 -dependent function

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

The neurovascular unit in brain function and disease

(2011) C. Lecrux et al.   Acta Physiologica

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions

(2011) Linnea R. Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

(2011) J. E. Rinholm et al.   JOURNAL OF NEUROSCIENCE

Strength Training, Walking, and Social Activity Improve Sleep in Nursing Home and Assisted Living Residents: Randomized Controlled Trial

(2011) Kathy C. Richards et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Cerebrovascular disorders: molecular insights and therapeutic opportunities

(2011) Erik Storkebaum et al.   NATURE NEUROSCIENCE

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

(2011) Karim Belarbi et al.   NEUROBIOLOGY OF DISEASE

The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model

(2011) Zheng Ke et al.   PLoS One

The Effect of Exercise Training on Obstructive Sleep Apnea and Sleep Quality: A Randomized Controlled Trial

(2011) Christopher E. Kline et al.   SLEEP

Effects of moderate aerobic exercise training on chronic primary insomnia

(2011) Giselle Soares Passos et al.   SLEEP MEDICINE

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

(2010) Maya A. Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of Aerobic Exercise on Mild Cognitive Impairment

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Aerobic fitness and obesity: relationship to cerebral white matter integrity in the brain of active and sedentary older adults

(2010) B. Marks et al.   BRITISH JOURNAL OF SPORTS MEDICINE

The Wnt /β-catenin signaling pathway in the adult neurogenesis

(2010) Lin Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effect of Resistance Exercise on Serum Levels of Growth Factors in Humans

(2010) S. Rojas Vega et al.   HORMONE AND METABOLIC RESEARCH

in vivo 3D Morphology of Astrocyte—Vasculature Interactions in the Somatosensory Cortex: Implications for Neurovascular Coupling

(2010) Addason F H McCaslin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypercholesterolemia and microvascular dysfunction: interventional strategies

(2010) Phoebe A Stapleton et al.   Journal of Inflammation-London

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Review: Sporadic cerebral amyloid angiopathy

(2010) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

(2010) Hyun-Sub Um et al.   NEUROSCIENCE RESEARCH

Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

(2010) Patrick J. Smith et al.   PSYCHOSOMATIC MEDICINE

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Exercise improves cognition and hippocampal plasticity in APOE ε4 mice

(2009) Kathryn Nichol et al.   Alzheimers & Dementia

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

(2009) E. Bullitt et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cerebral blood flow during exercise: mechanisms of regulation

(2009) Shigehiko Ogoh et al.   JOURNAL OF APPLIED PHYSIOLOGY

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

(2009) Carla M. Yuede et al.   NEUROBIOLOGY OF DISEASE

Reduced circulating angiogenic cells in Alzheimer disease

(2009) S-T Lee et al.   NEUROLOGY

The Effect of Physical Exercise on Endothelial Function

(2009) Samanta Di Francescomarino et al.   SPORTS MEDICINE

Regional White Matter Integrity Differentiates Between Vascular Dementia and Alzheimer Disease

(2009) Mojtaba Zarei et al.   STROKE

Wnt/Frizzled signaling in angiogenesis

(2008) Marielba Zerlin et al.   ANGIOGENESIS

N-Cadherin Levels in Endothelial Cells Are Regulated by Monolayer Maturity and p120 Availability

(2008) Deana M. Ferreri et al.   CELL COMMUNICATION AND ADHESION

Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons

(2008) Christian Lange-Asschenfeldt et al.   EXPERIMENTAL GERONTOLOGY

Forced and voluntary exercise differentially affect brain and behavior

(2008) J.L. Leasure et al.   NEUROSCIENCE

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES

Environmental Enrichment Counteracts Alzheimer’s Neurovascular Dysfunction in TgCRND8 Mice

(2007) Arne Herring et al.   BRAIN PATHOLOGY