Novel Anti-Alzheimer’s Therapeutic Molecules Targeting Amyloid Precursor Protein Processing
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Title
Novel Anti-Alzheimer’s Therapeutic Molecules Targeting Amyloid Precursor Protein Processing
Authors
Keywords
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Journal
Oxidative Medicine and Cellular Longevity
Volume 2020, Issue -, Pages 1-19
Publisher
Hindawi Limited
Online
2020-04-30
DOI
10.1155/2020/7039138
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Note: Only part of the references are listed.- KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor to Abate Alzheimer’s Disease
- (2020) Abdullah Al Mamun et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration
- (2020) Md. Ataur Rahman et al. CURRENT PHARMACEUTICAL DESIGN
- Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer’s Disease
- (2020) Md. Sahab Uddin et al. CURRENT PHARMACEUTICAL DESIGN
- TV 3326 for Alzheimer’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s‐like neuropathology
- (2020) Md. Sahab Uddin et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Estrogen Signaling in Alzheimer’s Disease: Molecular Insights and Therapeutic Targets for Alzheimer’s Dementia
- (2020) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease
- (2020) Md. Sahab Uddin et al. MOLECULES
- Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer’s Disease
- (2020) Abdullah Al Mamun et al. NEUROTOXICITY RESEARCH
- Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration
- (2020) Md. Sahab Uddin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
- (2019) Patricia Regina Manzine et al. BIOMEDICINE & PHARMACOTHERAPY
- Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
- (2019) Elizabeta Zaplatic et al. LIFE SCIENCES
- Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives
- (2019) Seetha Harilal et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology
- (2019) Md. Farhad Hossain et al. MOLECULAR NEUROBIOLOGY
- Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
- (2019) Bijo Mathew et al. ARCHIV DER PHARMAZIE
- Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
- (2019) Xinyi Wang et al. CELL RESEARCH
- Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest
- (2019) Md. Sahab Uddin et al. Frontiers in Cell and Developmental Biology
- Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning
- (2019) Md. Tanvir Kabir et al. CURRENT PHARMACEUTICAL DESIGN
- NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy
- (2019) Md. Tanvir Kabir et al. CURRENT PHARMACEUTICAL DESIGN
- Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders
- (2019) Md. Sahab Uddin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease
- (2019) Md. Sahab Uddin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
- (2018) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Blood Transcriptomic Biomarkers of Alzheimer's Disease Patients Treated with EHT 0202
- (2018) Laurent Désiré et al. JOURNAL OF ALZHEIMERS DISEASE
- Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis
- (2018) Chen-Chen Tan et al. JOURNAL OF ALZHEIMERS DISEASE
- Analyzing the chance of developing dementia among geriatric people: a cross-sectional pilot study in Bangladesh
- (2018) Md. Sahab Uddin et al. Psychogeriatrics
- Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis
- (2018) Md. Sahab Uddin et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology
- (2018) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials
- (2017) Thomas J. Nelson et al. JOURNAL OF ALZHEIMERS DISEASE
- BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease
- (2017) Federica Prati et al. JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer's disease: Innate immunity gone awry?
- (2017) Theodore B. VanItallie METABOLISM-CLINICAL AND EXPERIMENTAL
- Merck ends trial of potential Alzheimer’s drug verubecestat
- (2017) Nigel Hawkes BMJ-British Medical Journal
- Merck ends trial of potential Alzheimer’s drug verubecestat
- (2017) Nigel Hawkes BMJ-British Medical Journal
- Why Did Tarenflurbil Fail in Alzheimer's Disease?
- (2017) Bruno P. Imbimbo JOURNAL OF ALZHEIMERS DISEASE
- AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer’s Disease
- (2016) Gvido Cebers et al. JOURNAL OF ALZHEIMERS DISEASE
- Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
- (2016) Jack D. Scott et al. JOURNAL OF MEDICINAL CHEMISTRY
- Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?
- (2016) Matthew G. Bursavich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2016) Rafael de la Torre et al. LANCET NEUROLOGY
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- The BACE1 inhibitor verubecestat (MK-8931) reduces CNS -amyloid in animal models and in Alzheimers disease patients
- (2016) M. E. Kennedy et al. Science Translational Medicine
- Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease
- (2016) Jeffrey L. Cummings et al. Alzheimers Research & Therapy
- Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
- (2016) Riqiang Yan Translational Neurodegeneration
- Inhibition of protein aggregation and amyloid formation by small molecules
- (2015) Andrew J Doig et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The genetic landscape of Alzheimer disease: clinical implications and perspectives
- (2015) Caroline Van Cauwenberghe et al. GENETICS IN MEDICINE
- The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A Pharmacodynamic Responses in Mice, Dogs, and Humans
- (2015) P. C. May et al. JOURNAL OF NEUROSCIENCE
- Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment
- (2015) Sasanka Chakrabarti et al. Aging and Disease
- β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
- (2015) Xiaojuan Sun et al. Frontiers in Pharmacology
- Lessons from a BACE1 inhibitor trial: Off-site but not off base
- (2014) Debomoy K. Lahiri et al. Alzheimers & Dementia
- Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication
- (2014) William James Deardorff et al. Expert Review of Neurotherapeutics
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- (2014) Allen A. Thomas et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2014) H. Jacobsen et al. JOURNAL OF NEUROSCIENCE
- Retinoids as potential targets for Alzheimer's disease
- (2014) Rupinder K. Sodhi et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease
- (2014) Kelly Willemijn Menting et al. Frontiers in Aging Neuroscience
- Tau-aggregation inhibitor therapy for Alzheimer's disease
- (2013) Claude M. Wischik et al. BIOCHEMICAL PHARMACOLOGY
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects
- (2013) Yanke Yu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study
- (2013) Stephanie JB Vos et al. LANCET NEUROLOGY
- Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
- (2013) Victor L Villemagne et al. LANCET NEUROLOGY
- E2012-Induced Cataract and Its Predictive Biomarkers
- (2013) K. Nakano-Ito et al. TOXICOLOGICAL SCIENCES
- Recent developments of protein kinase inhibitors as potential AD therapeutics
- (2013) Volkmar Tell et al. Frontiers in Cellular Neuroscience
- γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
- (2013) Masayasu Okochi et al. Cell Reports
- Tau protein kinases: Involvement in Alzheimer's disease
- (2012) Ludovic Martin et al. AGEING RESEARCH REVIEWS
- Activation of α-secretase by curcumin-aminoacid conjugates
- (2012) Ramesh B. Narasingapa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease
- (2012) Hiroshi Fukasawa et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)
- (2012) Walter J Lukiw EXPERT OPINION ON EMERGING DRUGS
- Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
- (2012) Samuel W. Gerritz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
- (2012) Randall J. Bateman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
- (2012) John M Ringman et al. Alzheimers Research & Therapy
- Chemical Biology, Molecular Mechanism and Clinical Perspective of γ - Secretase Modulators in Alzheimers Disease
- (2011) Bruno Bulic et al. Current Neuropharmacology
- Role of microglia in CNS inflammation
- (2011) Manuel B. Graeber et al. FEBS LETTERS
- Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System
- (2011) Yoji Yonemura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Robust Central Reduction of Amyloid- in Humans with an Orally Available, Non-Peptidic -Secretase Inhibitor
- (2011) P. C. May et al. JOURNAL OF NEUROSCIENCE
- Unknown
- (2011) Daniel Paris et al. MOLECULAR MEDICINE
- Post-translational modifications of tau protein: Implications for Alzheimer's disease
- (2011) Ludovic Martin et al. NEUROCHEMISTRY INTERNATIONAL
- Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
- (2011) Todd E. Golde et al. NEURON
- 5-HT4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment
- (2011) Fei Shen et al. NEUROPHARMACOLOGY
- E2012: A novel gamma-secretase modulator-mechanism of action
- (2010) Hiroyuki Amino et al. Alzheimers & Dementia
- E2012, a novel gamma-secretase modulator, decreases plasma amyloid-beta (Aβ) levels in humans
- (2010) Christa Nagy et al. Alzheimers & Dementia
- E2012: A novel gamma-secretase modulator-pharmacology part
- (2010) Toshihide Hashimoto et al. Alzheimers & Dementia
- Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease
- (2010) Gary Small et al. Alzheimers & Dementia
- Novel pyrrolyl 2-aminopyridines as potent and selective human β-secretase (BACE1) inhibitors
- (2010) Michael S. Malamas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer’s Drugs
- (2010) Daniel Oehlrich et al. JOURNAL OF MEDICINAL CHEMISTRY
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy
- (2010) K. Bhaskar et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Drug development for Alzheimer's disease: Where are we now and where are we headed?
- (2009) Marwan N. Sabbagh American Journal Geriatric Pharmacotherapy
- The neuropathology of probable Alzheimer disease and mild cognitive impairment
- (2009) Julie A. Schneider et al. ANNALS OF NEUROLOGY
- A γ-secretase inhibitor decreases amyloid-β production in the central nervous system
- (2009) Randall J. Bateman et al. ANNALS OF NEUROLOGY
- NSAID-derived γ-secretase modulators. Part III: Membrane anchoring
- (2009) Stefanie Baumann et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A conformational constraint improves a β-secretase inhibitor but for an unexpected reason
- (2009) Ivory D. Hills et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin
- (2009) Frank Tippmann et al. FASEB JOURNAL
- Cell biology, regulation and inhibition of β-secretase (BACE-1)
- (2009) Clare E. Hunt et al. FEBS Journal
- Can Lithium or Valproate Untie Tangles in Alzheimer's Disease?
- (2009) Pierre N. Tariot et al. JOURNAL OF CLINICAL PSYCHIATRY
- Lithium Trial in Alzheimer's Disease
- (2009) Harald Hampel et al. JOURNAL OF CLINICAL PSYCHIATRY
- Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease
- (2008) Salim S. El-Amouri et al. AMERICAN JOURNAL OF PATHOLOGY
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain
- (2008) Delphine Boche et al. BRAIN PATHOLOGY
- Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)
- (2008) Walter J Lukiw EXPERT OPINION ON EMERGING DRUGS
- Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes
- (2008) Jiyeon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3 Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing
- (2008) Y. Wen et al. JOURNAL OF NEUROSCIENCE
- Dynamics of A Turnover and Deposition in Different -Amyloid Precursor Protein Transgenic Mouse Models Following -Secretase Inhibition
- (2008) D. Abramowski et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
- (2008) Romano Silvestri MEDICINAL RESEARCH REVIEWS
- Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
- (2008) Lars Bertram et al. NATURE REVIEWS NEUROSCIENCE
- Inhibition and modulation of γ-secretase for Alzheimer’s disease
- (2008) Michael S. Wolfe Neurotherapeutics
- Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
- (2003) H. F. Dovey et al. JOURNAL OF NEUROCHEMISTRY
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