Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia

(2020) I. A. Fridman et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

A review of phenformin, metformin, and imeglimin

(2020) Raghunandan Yendapally et al.   DRUG DEVELOPMENT RESEARCH

Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation

(2020) Yibao Ma et al.   Scientific Reports

Glutamine Addiction and Therapeutic Strategies in Lung Cancer

(2019) Karolien Vanhove et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy

(2019) Colin Rae et al.   Oncotarget

The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

(2019) Dongwei Xu et al.   Frontiers in Pharmacology

Oxygen in the tumor microenvironment: effects on dendritic cell function

(2019) Laurent M. Paardekooper et al.   Oncotarget

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

(2019) Lisha Xiang et al.   Cell Death & Disease

Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells

(2019) Bang-Jau You et al.   CHEMICAL RESEARCH IN TOXICOLOGY

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway

(2019) Chia-Cheng Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of SAA1 inhibits palmitate- or high-fat diet induced insulin resistance through suppression of the NF-κB pathway

(2019) Yong Wang et al.   MOLECULAR MEDICINE

2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation But Not Spheroid Growth

(2019) IRINI GEROGIANNI et al.   ANTICANCER RESEARCH

In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation

(2019) ALEKSANDRA CZUMAJ et al.   ANTICANCER RESEARCH

Anticancer properties of novel pyrazole‐containing biguanide derivatives with activating the adenosine monophosphate‐activated protein kinase signaling pathway

(2019) Sichun Zhou et al.   ARCHIV DER PHARMAZIE

Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer

(2019) Songtao Cheng et al.   CLINICAL SCIENCE

Phenformin as an Anticancer Agent: Challenges and Prospects

(2019) Rubiño et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Devimistat in combination with high dose cytarabine and mitoxantrone compared with high dose cytarabine and mitoxantrone in older patients with relapsed/refractory acute myeloid leukemia: ARMADA 2000 Phase III study

(2019) Timothy S Pardee et al.   Future Oncology

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met

(2019) Naeun Lee et al.   Metabolites

Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma

(2019) Yuanke Li et al.   ACS Applied Materials & Interfaces

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

(2019) Vilma Dembitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line

(2019) Giorgia Cioccoloni et al.   JOURNAL OF CHEMOTHERAPY

A combination of inhibitors of glycolysis, glutaminolysis and de�novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells

(2019) Alejandro Schcolnik‑Cabrera et al.   Oncology Letters

Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

(2019) Hui-Yen Chuang et al.   Scientific Reports

Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

(2019) Mei Peng et al.   Frontiers in Pharmacology

The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells

(2019) Chiara Bellio et al.   Cancers

Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies

(2019) Jiali Cheng et al.   Frontiers in Oncology

The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma

(2019) Luciana Y. de Almeida et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

(2019) Sarah E. LeBoeuf et al.   Cell Metabolism

Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes

(2019) Alexandru Andrei Tirpe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells

(2019) Maura Calvani et al.   Oxidative Medicine and Cellular Longevity

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

(2019) Hamidullah Khan et al.   Cell Reports

Cancer Energy Metabolism: Shutting Power off Cancer Factory

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities

(2018) Byung-Jin Jung et al.   Biomolecules & Therapeutics

A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia

(2018) Timothy S. Pardee et al.   CLINICAL CANCER RESEARCH

β-catenin-activated hepatocellular carcinomas are addicted to fatty acids

(2018) Nadia Senni et al.   GUT

T Cell Calcium Signaling Regulation by the Co-Receptor CD5

(2018) Claudia Freitas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease

(2018) Mehmet G. Badur et al.   METABOLIC ENGINEERING

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens

(2018) Sabrina S. Schatzman et al.   ACS Infectious Diseases

Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors

(2018) Paris Kosti et al.   Frontiers in Immunology

Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

(2018) Kim Ohl et al.   Frontiers in Immunology

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

(2018) Lingtong Meng et al.   ACS Nano

Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells

(2018) MICHAEL A. LEA et al.   ANTICANCER RESEARCH

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

A novel and compact review on the role of oxidative stress in female reproduction

(2018) Jiayin Lu et al.   Reproductive Biology and Endocrinology

Metabolic Profiles Associated With Metformin Efficacy in Cancer

(2018) Sylvia Andrzejewski et al.   Frontiers in Endocrinology

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions

(2018) Amira Saleh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

SPARC Inhibits Metabolic Plasticity in Ovarian Cancer

(2018) Christine Naczki et al.   Cancers

The effect of oxidized phospholipids on phenotypic polarization and function of macrophages

(2017) Vlad Serbulea et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production

(2017) Ryan Reyes et al.   GENE EXPRESSION

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

(2017) Subbroto Kumar Saha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells

(2017) Maryam Oladghaffari et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells

(2017) Joshua J. Souchek et al.   MOLECULAR CANCER THERAPEUTICS

Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

(2017) Alena Pecinova et al.   Oxidative Medicine and Cellular Longevity

Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Redox Regulation of Inflammatory Processes Is Enzymatically Controlled

(2017) Inken Lorenzen et al.   Oxidative Medicine and Cellular Longevity

Direct effects of phenformin on metabolism/bioenergetics and viability of SH‑SY5Y neuroblastoma cells

(2017) Fintan Geoghegan et al.   Oncology Letters

Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway

(2017) Zhiying Guo et al.   Oncotarget

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

Non-radioactive 2-deoxy-2-fluoro-D-glucose inhibits glucose uptake in xenograft tumours and sensitizes HeLa cells to doxorubicin in vitro

(2017) Sarah Niccoli et al.   PLoS One

Combined Treatment with 2-Deoxy-D-Glucose and Doxorubicin Enhances the in Vitro Efficiency of Breast Cancer Radiotherapy

(2016) Jalil Pirayesh Islamian et al.   Asian Pacific Journal of Cancer Prevention

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2016) Luke A.J. O’Neill et al.   JOURNAL OF CELL BIOLOGY

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells

(2016) Minoru Tomizawa et al.   Oncology Letters

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

(2016) Geneviève Deblois et al.   Nature Communications

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma

(2016) Tiziana Petrachi et al.   Oncotarget

High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia

(2016) Jinlong Shi et al.   EBioMedicine

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

(2015) Dania C. Liemburg-Apers et al.   ARCHIVES OF TOXICOLOGY

Targeting leukemia's "fatty tooth"

(2015) I. Samudio et al.   BLOOD

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells

(2015) Suman Mukhopadhyay et al.   CELL CYCLE

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism

(2015) Victor Tkachev et al.   JOURNAL OF IMMUNOLOGY

Cancer’s Fuel Choice: New Flavors for a Picky Eater

(2015) Gina M. DeNicola et al.   MOLECULAR CELL

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma

(2015) Giuseppe Lucarelli et al.   Oncotarget

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

(2015) Ling Li et al.   Redox Biology

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.

(2015) Leonidas Platanias et al.   Oncotarget

Redox Regulation of Ion Channels

(2014) Ivan Bogeski et al.   ANTIOXIDANTS & REDOX SIGNALING

Dichloroacetate and cancer: New home for an orphan drug?

(2014) Shyam Kankotia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death

(2014) L. Yin et al.   BLOOD

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis

(2014) Angelo D'Alessandro et al.   Molecular BioSystems

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

(2014) María Cristina Estañ et al.   PLoS One

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondria and Metabolic Homeostasis

(2013) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology

(2013) Jennifer L. Meitzler et al.   ANTIOXIDANTS & REDOX SIGNALING

The LKB1-AMPK Pathway—Friend or Foe in Cancer?

(2013) D. Grahame Hardie   CANCER CELL

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations

(2013) Ashkan Emadi et al.   EXPERIMENTAL HEMATOLOGY

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

(2013) Emanuele Marzetti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity

(2013) Toshimitsu Ohashi et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of SPARC in bladder cancer enhances carcinogenesis and progression

(2013) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch

(2013) J B Tennakoon et al.   ONCOGENE

Redox regulation of the immune response

(2013) Johanna M Gostner et al.   REDOX REPORT

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Manganese superoxide dismutase: A regulator of T cell activation-induced oxidative signaling and cell death

(2012) Marcin Mikołaj Kamiński et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

(2012) Maura Calvani et al.   PLoS One

Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response

(2012) M. Beneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

(2012) Marcin M. Kamiński et al.   Cell Reports

Antileukemic effects of AMPK activators on BCR-ABL-expressing cells

(2011) E. Vakana et al.   BLOOD

Src activates HIF-1α not through direct phosphorylation of HIF-1α-specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway

(2011) Ho-Youl Lee et al.   CARCINOGENESIS

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

(2011) Giuseppina Comito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

(2011) Barbara Molon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

(2011) Zuzana Zachar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

(2010) Issam Ben Sahra et al.   Autophagy

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells

(2010) Melissa A. Fath et al.   CANCER BIOLOGY & THERAPY

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

(2010) David A. Patten et al.   MOLECULAR BIOLOGY OF THE CELL

Antiangiogenic Activity of 2-Deoxy-D-Glucose

(2010) Jaime R. Merchan et al.   PLoS One

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chemosensitizing and cytotoxic effects of 2-deoxy-D-glucose on breast cancer cells

(2009) RebeccaL Aft et al.   Journal of Cancer Research and Therapeutics

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications

(2008) Ashok Agarwal et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Differential Involvement of Vascular Endothelial Growth Factor in the Survival of Hypoxic Colon Cancer Cells

(2008) M. Calvani et al.   CANCER RESEARCH

Increased chemosensitivity and elevated reactive oxygen species are mediated by glutathione reduction in glutamine deprived neuroblastoma cells

(2008) Sakurako Izaki et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

(2008) Metin Kurtoglu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE