The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling

(2018) Wei Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

(2018) Yuko Murakami et al.   BMC CANCER

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma

(2018) Bing Tian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice

(2018) Zhenyu Shen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway

(2018) Xiaoxue Zhang et al.   FREE RADICAL RESEARCH

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2018) Stephen A Harrison et al.   LANCET

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway

(2018) Xinyan Peng et al.   MOLECULES

Ethyl pyruvate can alleviate alcoholic liver disease through inhibiting Nrf2 signaling pathway

(2018) Fei Shen et al.   Experimental and Therapeutic Medicine

Protective effects of morin on lipopolysaccharide/ d -galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways

(2017) Ye Tian et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH

(2017) Pierluigi Ramadori et al.   Oxidative Medicine and Cellular Longevity

Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

(2017) Ya-Hui Ni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury

(2017) Mian Ge et al.   Cell Death & Disease

The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

(2017) Dongwei Xu et al.   Cell Death & Disease

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

(2017) Chen-wei Pan et al.   Oncotarget

Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats

(2017) Hua Fan et al.   MEDICAL SCIENCE MONITOR

Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation

(2017) Jeong Il Yu et al.   Scientific Reports

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2

(2016) Michael Karin et al.   CARCINOGENESIS

Indazolo[3,2-b]quinazolinones Attack Hepatocellular Carcinoma Hep3B Cells by Inducing Mitochondrial-Dependent Apoptosis and Inhibition of Nrf2/ARE Signaling Pathway

(2016) Y. Zhang et al.   CURRENT MOLECULAR MEDICINE

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Chen-wei Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Xingkai Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

(2016) Jinhui Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis

(2016) Chunfeng Lu et al.   MOLECULAR PHARMACEUTICS

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway

(2015) Liang Shi et al.   Asian Pacific Journal of Cancer Prevention

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

(2015) Xinhua Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

(2015) B Liu et al.   Cell Death & Disease

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

(2015) Sílvia S. Chambel et al.   Biomed Research International

ATF3-Mediated NRF2/HO-1 Signaling Regulates TLR4 Innate Immune Responses in Mouse Liver Ischemia/Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

(2014) Peter Dietrich et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Multifactorial Comparative Proteomic Study of Cytochrome P450 2E1 Function in Chronic Alcohol Administration

(2014) Yuan Wang et al.   PLoS One

Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus

(2014) Kazuo Sugiyama et al.   PLoS One

Nrf2-mediated antioxidant response by ethanolic extract ofSida cordifoliaprovides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism

(2014) S. Rejitha et al.   REDOX REPORT

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice

(2013) Kazuhiro Kudoh et al.   ANNALS OF SURGERY

Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis

(2013) Richard Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)

(2013) Annalisa Petrelli et al.   HEPATOLOGY

Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice

(2013) Zhigang Wang et al.   HEPATOLOGY

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants

(2013) Bibo Ke et al.   JOURNAL OF HEPATOLOGY

The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice

(2013) Manchang Liu et al.   KIDNEY INTERNATIONAL

Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

(2013) Chunhua Wang et al.   Lipids in Health and Disease

Pathogenesis of hepatic steatosis: The link between hypercortisolism and non-alcoholic fatty liver disease

(2013) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

HCV and Oxidative Stress in the Liver

(2013) Alexander Ivanov et al.   Viruses-Basel

Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction

(2012) Wei-Chun Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nrf2: A Potential Target for New Therapeutics in Liver Disease

(2012) A M Bataille et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury

(2012) Feng Zhang et al.   STROKE

Nrf2 activation prevents cadmium-induced acute liver injury

(2012) Kai C. Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins

(2011) Monica Carvajal-Yepes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

(2011) Alexander V. Ivanov et al.   PLoS One

Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver

(2010) Soo Han Bae et al.   HEPATOLOGY

Hepatitis B Virus Induces Expression of Antioxidant Response Element-regulated Genes by Activation of Nrf2

(2010) Stephanie Schaedler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chronic Ethanol Consumption Induces Global Hepatic Protein Hyperacetylation

(2009) Blythe D. Shepard et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

(2009) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway

(2009) D. Burdette et al.   JOURNAL OF GENERAL VIROLOGY

Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders

(2008) Jian Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA