Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

(2019) Eloy Moreno Roig et al.   Cells

Nm23-H1 inhibits hypoxia induced epithelial-mesenchymal transition and stemness in non-small cell lung cancer cells

(2019) Cun-en Wu et al.   BIOLOGICAL CHEMISTRY

miR‐155‐5p and miR‐760 mediate radiation therapy suppressed malignancy of non‐small cell lung cancer cells

(2019) Lin Zhu et al.   BIOFACTORS

MiR-200c downregulates HIF-1α and inhibits migration of lung cancer cells

(2019) Yuree Byun et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis

(2019) Cornelia Braicu et al.   Cancers

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

(2019) Swati Dabral et al.   Nature Communications

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells

(2018) Mingliang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness

(2018) Jingjing Wang et al.   CANCER LETTERS

Overview upon miR-21 in lung cancer: focus on NSCLC

(2018) Cecilia Bica-Pop et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The evolving role of lymphatics in cancer metastasis

(2018) Rae H Farnsworth et al.   CURRENT OPINION IN IMMUNOLOGY

MicroRNA-31-5p enhances the Warburg effect via targeting FIH

(2018) Biying Zhu et al.   FASEB JOURNAL

Hypoxia inducible factor-1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia-induced angiogenesis in lung cancer

(2018) Hongjun Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

(2018) Ya-Ling Hsu et al.   MOLECULAR THERAPY

The silent healer: miR-205-5p up-regulation inhibits epithelial to mesenchymal transition in colon cancer cells by indirectly up-regulating E-cadherin expression

(2018) Diana Gulei et al.   Cell Death & Disease

Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α

(2018) Xu Chen et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Modeling of mesenchymal hybrid epithelial state and phenotypic transitions in EMT and MET processes of cancer cells

(2018) Peng He et al.   Scientific Reports

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Epithelial, mesenchymal and hybrid epithelial/mesenchymal phenotypes and their clinical relevance in cancer metastasis

(2017) Minal Garg   EXPERT REVIEWS IN MOLECULAR MEDICINE

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Upregulation of Wnt signaling under hypoxia promotes lung cancer progression

(2017) Chun-Fu Hong et al.   ONCOLOGY REPORTS

HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer

(2017) Zhao-Jia Gao et al.   TUMOR BIOLOGY

MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression

(2017) Xin Liu et al.   Oncotarget

SOX9 Elevation Acts with Canonical WNT Signaling to Drive Gastric Cancer Progression

(2016) Juliana Carvalho Santos et al.   CANCER RESEARCH

Interaction between Wnt/β-catenin pathway and microRNAs regulates epithelial-mesenchymal transition in gastric cancer (Review)

(2016) CUNEN WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SOX9 drives WNT pathway activation in prostate cancer

(2016) Fen Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Twist may be associated with invasion and metastasis of hypoxic NSCLC cells

(2016) Ling Wei et al.   TUMOR BIOLOGY

SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling

(2016) Corinne Prévostel et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

(2016) Jingyu Zhang et al.   Journal of Clinical Medicine

Tumor Budding: The Name is EMT. Partial EMT.

(2016) Alexandru Grigore et al.   Journal of Clinical Medicine

Hypoxia Induced NF-κB

(2016) Laura D’Ignazio et al.   Cells

Hypoxic regulation of the noncoding genome and NEAT1

(2015) Hani Choudhry et al.   Briefings in Functional Genomics

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

(2015) Hongming Teng et al.   Marine Drugs

Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer

(2015) Chun-Wen Cheng et al.   Oncotarget

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

(2015) Agnieszka Zimna et al.   Biomed Research International

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis

(2015) Xun Yuan et al.   Scientific Reports

NCRNA Combined Therapy as Future Treatment Option for Cancer

(2014) Cornelia Braicu et al.   CURRENT PHARMACEUTICAL DESIGN

The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer

(2014) John G Foster et al.   Future Oncology

Prognosis value of HIF-1α expression in patients with non-small cell lung cancer

(2014) Qian Wang et al.   GENE

Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinoma

(2014) Hassan Wael et al.   LUNG CANCER

Role of lymphatic vasculature in regional and distant metastases

(2014) Simona Podgrabinska et al.   MICROVASCULAR RESEARCH

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyperglycemia Promotes K-Ras-Induced Lung Tumorigenesis through BASCs Amplification

(2014) Carla Micucci et al.   PLoS One

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery

(2014) Mihaela Aldea et al.   TUMOR BIOLOGY

Hypoxia Induces VEGF-C Expression in Metastatic Tumor Cells via a HIF-1α-Independent Translation-Mediated Mechanism

(2014) Florent Morfoisse et al.   Cell Reports

The effects of nonspecific HIF1αinhibitors on development of castrate resistance and metastases in prostate cancer

(2014) Weranja K. B. Ranasinghe et al.   Cancer Medicine

Notch Pathway Activity Identifies Cells with Cancer Stem Cell-like Properties and Correlates with Worse Survival in Lung Adenocarcinoma

(2013) K. A. Hassan et al.   CLINICAL CANCER RESEARCH

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells

(2013) Cornelia Braicu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

Deletion or Overexpression of Mitochondrial NAD+Carriers inSaccharomyces cerevisiaeAlters Cellular NAD and ATP Contents and Affects Mitochondrial Metabolism and the Rate of Glycolysis

(2011) Gennaro Agrimi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer

(2011) A Lecharpentier et al.   BRITISH JOURNAL OF CANCER

Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas

(2011) Hidefumi Sasaki   Molecular Medicine Reports

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

(2010) Tom Donnem et al.   CANCER

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB Signaling: A Tale of Two Pathways in Skeletal Myogenesis

(2010) Nadine Bakkar et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Small Cell Lung Cancer

(2009) Taimur Sher et al.   MAYO CLINIC PROCEEDINGS

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Human cancers converge at the HIF-2α oncogenic axis

(2009) Aleksandra Franovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

VEGFR-3 Expression Is Restricted to Blood and Lymphatic Vessels in Solid Tumors

(2008) Tatiana V. Petrova et al.   CANCER CELL

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression

(2008) Kristina E. Hoot et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA