Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line

In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation

(2019) ALEKSANDRA CZUMAJ et al.   ANTICANCER RESEARCH

FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells

(2018) Mingjing Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy

(2018) Alejandro Schcolnik-Cabrera et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non–small Cell Lung Cancers

(2018) Sean P. Pitroda et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

(2018) Soumaya Kouidhi et al.   Frontiers in Immunology

PD-L1 expression is an independent predictor of favorable outcome in patients with localized esophageal adenocarcinoma

(2018) Dagmar Kollmann et al.   OncoImmunology

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors

(2017) Ornella Franzese et al.   Oncotarget

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

(2017) Timothy S. Heuer et al.   EBioMedicine

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme

(2017) Brittany A. Goods et al.   PLoS One

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

(2016) Curtis A. Clark et al.   CANCER RESEARCH

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway

(2016) Haiyu Wang et al.   Cancer Medicine

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

(2016) Lauren Van Der Kraak et al.   Journal for ImmunoTherapy of Cancer

Elevated Cellular PD1/PD-L1 Expression Confers Acquired Resistance to Cisplatin in Small Cell Lung Cancer Cells

(2016) Fei Yan et al.   PLoS One

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro

(2015) GIORGIA CIOCCOLONI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Crystal Structure and Substrate Specificity of Human Thioesterase 2

(2015) Melissa K. Ritchie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer

(2015) Dirk O Bauerschlag et al.   Journal of Translational Medicine

Folate Receptor-Targeted Polymeric Micellar Nanocarriers for Delivery of Orlistat as a Repurposed Drug against Triple-Negative Breast Cancer

(2015) R. Paulmurugan et al.   MOLECULAR CANCER THERAPEUTICS

Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids

(2015) DIANA CERVANTES-MADRID et al.   ONCOLOGY REPORTS

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

(2015) Martin C. Sadowski et al.   Oncotarget

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

(2014) S. Muenst et al.   BREAST CANCER RESEARCH AND TREATMENT

Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis

(2014) Susanne Grube et al.   JOURNAL OF NEURO-ONCOLOGY

Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer

(2014) Yunlang Cai et al.   MEDICAL ONCOLOGY

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

(2013) Kathryn E. Hopperton et al.   EXPERIMENTAL CELL RESEARCH

The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas

(2013) M. Agostini et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

(2012) F Seguin et al.   BRITISH JOURNAL OF CANCER

Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration

(2012) Yong Shu et al.   Indian Journal of Pathology and Microbiology

Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat

(2012) HUI-QIONG HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy

(2012) Madhuri Sankaranarayanapillai et al.   MOLECULAR IMAGING AND BIOLOGY

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma

(2012) A. P. Bhatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression pathway analysis to predict response to neoadjuvant docetaxel and capecitabine for breast cancer

(2009) Larissa A. Korde et al.   BREAST CANCER RESEARCH AND TREATMENT

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

(2008) Lynn M. Knowles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Factors for Leukemic Induction Failure in Children With Acute Lymphoblastic Leukemia and Outcome After Salvage Therapy: The FRALLE 93 Study

(2008) Caroline Oudot et al.   JOURNAL OF CLINICAL ONCOLOGY

Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death

(2008) J. L. Little et al.   MOLECULAR CANCER THERAPEUTICS

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS