Targeting epigenetic DNA and histone modifications to treat kidney disease

Genome-wide DNA methylation analysis in renal ischemia reperfusion injury

(2017) Yanlong Zhao et al.   GENE

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

(2017) Linda Xiaoyan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

(2017) Daigo Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression

(2017) Björn Tampe et al.   KIDNEY INTERNATIONAL

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

(2017) Chunyuan Guo et al.   KIDNEY INTERNATIONAL

The role of short-chain fatty acids in kidney injury induced by gut-derived inflammatory response

(2017) Wei Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of epigenetics in renal ageing

(2017) Paul G. Shiels et al.   Nature Reviews Nephrology

SP425EFFECTS OF APABETALONE (RVX-208) ON SERUM ALBUMIN IN SUBJECTS WITH CVD, DIABETES AND CHRONIC KIDNEY DISEASE; A POST-HOC ANALYSIS OF THE ASSURE AND SUSTAIN CLINICAL TRIALS

(2017) Ewelina Kulikowski et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury

(2017) Taotao Ma et al.   Cell Death & Disease

Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

(2017) Sylwia Wasiak et al.   Journal of Cardiovascular Translational Research

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations

(2017) Qianqian Wang et al.   Scientific Reports

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

(2017) Timothy D. Hewitson et al.   Frontiers in Pharmacology

Bromodomains: Structure, function and pharmacology of inhibition

(2016) Elena Ferri et al.   BIOCHEMICAL PHARMACOLOGY

The Alarmin Properties of DNA and DNA-associated Nuclear Proteins

(2016) Melinda Magna et al.   CLINICAL THERAPEUTICS

Histone lysine crotonylation during acute kidney injury in mice

(2016) Olga Ruiz-Andres et al.   Disease Models & Mechanisms

DNA methylation profiling reveals differences in the 3 human monocyte subsets and identifies uremia to induce DNA methylation changes during differentiation

(2016) Adam M. Zawada et al.   Epigenetics

DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys

(2016) Yu-Ting Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage

(2016) Beatriz Suarez-Alvarez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression

(2016) Taisuke Irifuku et al.   KIDNEY INTERNATIONAL

Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity

(2016) Punithavathi Ranganathan et al.   KIDNEY INTERNATIONAL

The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury

(2016) Olga Ruiz-Andres et al.   KIDNEY INTERNATIONAL

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

(2016) Andrew L. Siebel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Kidney Cell Death Induces Renal Necroinflammation

(2016) Shrikant R. Mulay et al.   SEMINARS IN NEPHROLOGY

Molecular targets of curcumin for cancer therapy: an updated review

(2016) Pandima Devi Kasi et al.   TUMOR BIOLOGY

Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model

(2016) Elerson C. Costalonga et al.   Biomed Research International

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

Class-Specific Histone/Protein Deacetylase Inhibition Protects Against Renal Ischemia Reperfusion Injury and Fibrosis Formation

(2015) M. H. Levine et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

5-Aza-2'-Deoxycytidine and CDDP Synergistically Induce Apoptosis in Renal Carcinoma Cells via Enhancing the APAF-1 Activity

(2015) Xiaojun Zhu et al.   Clinical Laboratory

Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat

(2015) Sabbir Khan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review

(2015) F. Vahid et al.   GENE

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

(2015) Xia Zhou et al.   HUMAN MOLECULAR GENETICS

Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis

(2015) K. Sasaki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression

(2015) X. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes

(2015) Daniel Mar et al.   KIDNEY INTERNATIONAL

Recent developments in epigenetics of acute and chronic kidney diseases

(2015) Marpadga A. Reddy et al.   KIDNEY INTERNATIONAL

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

Epigenetic regulation in the acute kidney injury to chronic kidney disease transition

(2015) Roxana Rodríguez-Romo et al.   NEPHROLOGY

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

(2015) Lei-lei Fu et al.   Oncotarget

Effects of Valproic Acid and Dexamethasone Administration on Early Bio-Markers and Gene Expression Profile in Acute Kidney Ischemia-Reperfusion Injury in the Rat

(2015) Ryan W. Speir et al.   PLoS One

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors

(2014) C Arimany-Nardi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Transcription Factor Acetylation in Diabetic Kidney Disease

(2014) R. Liu et al.   DIABETES

TET proteins and 5-methylcytosine oxidation in hematological cancers

(2014) Myunggon Ko et al.   IMMUNOLOGICAL REVIEWS

KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria

(2014) Kaori Hayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

TWEAK and the progression of renal disease: clinical translation

(2014) A. B. Sanz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epigenetics: a new way to look at kidney diseases

(2014) P. Beckerman et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

Histone Deacetylase Inhibitors and Epigenetic Modifications as a Novel Strategy in Renal Cell Carcinoma

(2013) Swathi Ramakrishnan et al.   CANCER JOURNAL

Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation

(2013) Jing Zhang et al.   FASEB JOURNAL

Interplay between chromatin state, regulator binding, and regulatory motifs in six human cell types

(2013) J. Ernst et al.   GENOME RESEARCH

Understanding the Epigenetic Syntax for the Genetic Alphabet in the Kidney

(2013) K. Susztak   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone Deacetylase Inhibitor Enhances Recovery after AKI

(2013) C. Cianciolo Cosentino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HDAC Dependent Transcriptional Repression of Bmp-7 Potentiates TGF-β Mediated Renal Fibrosis in Obstructive Uropathy

(2013) Scott R. Manson et al.   JOURNAL OF UROLOGY

Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling

(2013) Na Liu et al.   PLoS One

Elevated Klotho Promoter Methylation Is Associated with Severity of Chronic Kidney Disease

(2013) Jing Chen et al.   PLoS One

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development

(2013) Yi-An Ko et al.   GENOME BIOLOGY

Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion

(2012) Ning Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Acute kidney injury and chronic kidney disease: an integrated clinical syndrome

(2012) Lakhmir S. Chawla et al.   KIDNEY INTERNATIONAL

HDAC inhibitors in kidney development and disease

(2012) Lauren L. Brilli et al.   PEDIATRIC NEPHROLOGY

Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

(2011) Andrew Advani et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

HMG-CoA Reductase Activation and Urinary Pellet Cholesterol Elevations in Acute Kidney Injury

(2011) A. C. Johnson et al.   Clinical Journal of the American Society of Nephrology

DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy

(2011) Carmen Sapienza et al.   Epigenetics

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

HDACi: molecular mechanisms and therapeutic implications in the innate immune system

(2011) Bandar Ali Suliman et al.   IMMUNOLOGY AND CELL BIOLOGY

Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation

(2011) Shaowei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic Acid Attenuates Proteinuria and Kidney Injury

(2011) K. Van Beneden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor

(2011) Richard E. Gilbert et al.   KIDNEY INTERNATIONAL

Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury

(2011) Ion D. Bucaloiu et al.   KIDNEY INTERNATIONAL

Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences

(2011) Sun Woo Kang et al.   BMC Nephrology

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10

(2010) Sufyan G. Sayyed et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fine Tuning Gene Expression: The Epigenome

(2010) Davoud Mohtat et al.   SEMINARS IN NEPHROLOGY

Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction

(2010) Fumitaka Kinugasa et al.   TRANSPLANT IMMUNOLOGY

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

(2009) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats

(2009) Kulbhushan Tikoo et al.   TOXICOLOGY LETTERS

Renal Ischemia-Induced Cholesterol Loading

(2008) Masayo Naito et al.   AMERICAN JOURNAL OF PATHOLOGY

Endotoxin Mediates Recruitment of RNA Polymerase II to Target Genes in Acute Renal Failure

(2008) M. Naito et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epigenetic Regulation of BMP7 in the Regenerative Response to Ischemia

(2008) T. Marumo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ischemia- reperfusion Injury and Its Influence on the Epigenetic Modification of the Donor Kidney Genome

(2008) Marie D. Parker et al.   TRANSPLANTATION