Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Victoria A. Khotina, Alexander N. Orekhov
Summary: Selenium is a vital trace element necessary for metabolic processes, protection against oxidative stress, and cardiovascular system functioning. Deficiency in selenium has been linked to various cardiovascular diseases including Keshan's disease, heart failure, coronary heart disease, myocardial infarction, and atherosclerosis. Through selenoenzymes and selenoproteins, selenium is involved in important processes such as regulation of redox homeostasis, oxidative stress, calcium flux, and thyroid hormone metabolism; an imbalance in selenium supply may disrupt these processes.
Article
Nutrition & Dietetics
Claire Hogan, Anthony V. Perkins
Summary: Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Article
Plant Sciences
Tao Liu, Xiaoting Liu, Rangrang Zhou, Hong Chen, Huaigang Zhang, Bo Zhang
Summary: Selenium is shown to have a significant impact on gene expression in oats, particularly in key genes related to selenate metabolism. The study identified 27 unigenes associated with selenate metabolism, with key genes exhibiting dramatic upregulation under selenate treatment. The research provides insights into the mechanisms underlying selenium uptake and metabolism in oats under high-selenium conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Carmen Beatrice Dogaru, Corina Muscurel, Carmen Duta, Irina Stoian
Summary: This review discusses the identity and functions of several less-known selenoproteins, which play important roles in various physiological and pathogenic processes, including antioxidant defense, anti-inflammation, anti-apoptosis, and immune and inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Rannapaula Lawrynhuk Urbano Ferreira, Karine Cavalcanti Mauricio Sena-Evangelista, Eduardo Pereira de Azevedo, Francisco Irochima Pinheiro, Ricardo Ney Cobucci, Lucia Fatima Campos Pedrosa
Summary: Selenium plays a crucial role in various bodily functions and maintaining a healthy gut microbiota. Its symbiotic relationship with gut bacteria helps in improving the bioavailability of selenocompounds and balancing microbial flora to prevent health damage associated with dysbiosis. However, selenium deficiency can lead to a phenotype of gut microbiota that is more susceptible to certain diseases, highlighting the importance of adequate selenium intake for both human and bacterial health.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Barbara Rita Cardoso, Larissa Lago, Aimee Linda Dordevic, Eugene Anthony Kapp, Anna M. Raines, Roger A. Sunde, Blaine Russel Roberts
Summary: The study identified candidate proteins in the liver regulated by dietary selenium intake, ranging from deficiency to toxic levels, and found a U-shaped dose-response relationship between selenium status and health outcomes. The results suggest that changes in selenium levels can impact the metabolism of glutathione, xenobiotics, and amino acids in the body.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Neurosciences
Daniel J. Torres, Naghum Alfulaij, Marla J. Berry
Summary: The stress response is crucial for organisms to survive adverse environmental conditions, although high levels of stress hormone glucocorticoids can have negative effects on the brain. Selenium, an antioxidant micronutrient, has been shown to protect against the impact of external stress and normalize neurological function.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Nutrition & Dietetics
Xin Huang, Yu-Lan Dong, Tong Li, Wei Xiong, Xu Zhang, Peng-Jie Wang, Jia-Qiang Huang
Summary: Selenium is essential for maintaining a healthy physiological state, but deficiencies or excesses can lead to various diseases related to cognitive decline, immune disorders, and metabolic risks. MiRNAs play crucial roles in regulating interactions between the environment and genes, but the mechanisms of selenium metabolism and miRNA regulation remain unclear.
Article
Biochemistry & Molecular Biology
Brenna Flowers, Allison Poles, Irida Kastrati
Summary: There is an urgent need for new and improved therapeutic strategies in breast cancer, and selenium supplementation may play a critical role in improving breast cancer survival rates. However, further research is needed to understand the tissue-specific mechanisms and genetic variations related to selenium's effects.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano, Maria Stefania Sinicropi, Alessia Carocci
Summary: Selenium is a vital element for human and animal health, playing a significant role in various bodily functions. However, excessive intake of selenium can be harmful. It supports antioxidant defense systems, hormone metabolism, reproductive functions, and neuroprotection. Optimizing selenium intake is important for preventing diseases related to selenium deficiency or excess.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Sojit Tomo, Gangam Saikiran, Mithu Banerjee, Sushmita Paul
Summary: The disruption of antioxidant defense in severe acute respiratory syndrome due to SARS-CoV infection has been demonstrated, with selenium playing a major role in reducing reactive oxygen species produced in response to viral infections. Selenium also inhibits NF-kappa B activation, thus alleviating inflammation. In viral infections, selenoproteins have been found to inhibit type I interferon responses and modulate T cell proliferation and oxidative burst in macrophages. Virally encoded selenoproteins have been identified in various viral genomes, and potential selenoproteins in the COVID-19 genome may provide further insights into their role in viral pathogenesis.
Article
Nutrition & Dietetics
Nada F. Abo El-Magd, Priscila O. Barbosa, Julia Nick, Viviana Covalero, Giacomo Grignetti, Giovanna Bermano
Summary: The study showed that selenium as selenite prevented adipogenesis by increasing antioxidant selenoprotein expression, reducing inflammatory markers, leading to decreased differentiation and lipid deposition, providing potential insights for preventing obesity through novel dietary approaches.
Review
Biochemistry & Molecular Biology
Ruihua Ye, Jiaqiang Huang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: Selenium, as an essential trace element, has been proven effective in alleviating intestinal diseases such as inflammatory bowel diseases due to its excellent antioxidant function. Intestinal diseases caused by chronic inflammation are among the most important threats to human health, and selenium plays a role in mitigating their impact.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Briana K. Shimada, Naghum Alfulaij, Lucia A. Seale
Summary: Selenium is an essential trace element crucial for cardiovascular health through its incorporation into selenoproteins, which are key to maintaining proper cardiovascular function. Deficiency in selenium can lead to various cardiovascular diseases, and selenium may potentially serve as a complementary therapy for prevention or treatment of cardiovascular disease by interacting with microRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tania C. Araujo-Jorge, Maria Teresa Rivera, Jean Vanderpas, Luciana R. Garzoni, Anna Cristina C. Carvalho, Mariana C. Waghabi, Marcelo T. Holanda, Mauro F. F. Mediano, Alejandro M. Hasslocher-Moreno, Maria da Gloria Bonecini-Almeida, Roberto M. Saraiva, Roberto R. Ferreira
Summary: This review presents recent studies on the potential use of selenium as a complementary therapy for chronic Chagas disease cardiomyopathy (CCC), showing evidence of its benefits in preventing heart failure and improving heart function. The review also discusses the complex pathophysiology of CCC and the role of selenium in immune response and fibrosis regulation.
Article
Pediatrics
Heitor P. Leite, Rodrigo Medina, Emilio L. Junior, Tulio Konstantyner
Summary: This study found that elevated serum troponin I levels in children on admission are independently associated with adverse outcomes, taking into account the severity of acute systemic inflammatory response syndrome, serum lactate concentrations, and nutritional status of the patients.
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2023)
Article
Nutrition & Dietetics
Emilio Lopes, Heitor Pons Leite, Maria do Carmo Pinho Franco, Tulio Konstantyner
Summary: This study found that erythrocyte selenium status is associated with endothelial activation in the early phase of systemic inflammatory response in children and has a protective effect on multiple organ dysfunction during their PICU stay.
CLINICAL NUTRITION ESPEN
(2022)
Article
Nutrition & Dietetics
Heitor P. Leite, Eduardo F. Hatanaka, Giovana Galati S. Sabio, Maria Carvalho F. de Camargo
Summary: This study found that anemia affects almost one-third of children with intestinal failure and its frequency decreases during the follow-up period. Hemoglobin levels are associated with inflammatory response and serum micronutrient concentrations.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Claudia Bezerra de Almeida, Heitor Pons Leite, Emilio Lopes Junior, Tulio Konstantyner, Maria do Carmo Pinho Franco
Summary: Unlike plasma selenium, erythrocyte selenium is not affected by the systemic inflammatory response in critically ill children and is associated with selenoprotein P concentrations. Erythrocyte selenium may be a more reliable marker than plasma selenium for evaluating the selenium status in critically ill children.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Pediatrics
Thais Claudia Roma de Oliveira Konstantyner, Camila Bertini Martins, Aecio Flavio Teixeira de Gois, Braian Valerio Cassiano de Castro, Tulio Konstantyner
Summary: This study aimed to estimate the temporal trend of accidents with venomous animals in children and adolescents. The results showed an upward trend in the incidence rates in the North, Northeast, Midwest, and Southeast macro-regions of Brazil, as well as in children in the South region. The average annual incidence rates were higher in the 10-19 age group. Scorpions, snakes, and spiders were the most frequent types of accidents, with varying trends based on the geographic macro-region.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Multidisciplinary Sciences
Ana Silvia Scavacini Marinonio, Milton Harumi Miyoshi, Daniela Testoni Costa-Nobre, Adriana Sanudo, Kelsy Catherina Nema Areco, Mandira Daripa Kawakami, Rita de Cassia Xavier Balda, Tulio Konstantyner, Paulo Bandiera-Paiva, Rosa Maria Vieira de Freitas, Lilian Cristina Correia Morais, Monica La Porte Teixeira, Bernadette Cunha Waldvogel, Carlos Roberto Veiga Kiffer, Maria Fernanda Branco de Almeida, Ruth Guinsburg
Summary: This study aimed to analyze the temporal trends of prevalence, neonatal mortality, and lethality of congenital diaphragmatic hernia (CDH) in Sao Paulo State, Brazil. The study found a significant increase in CDH prevalence and neonatal mortality over a 12-year period, while the lethality remained stable and high.
Article
Pediatrics
Maria Fernanda B. de Almeida, Adriana Sanudo, Kelsy N. Areco, Rita de Cassia X. Balda, Daniela T. Costa-Nobre, Mandira D. Kawakami, Tulio Konstantyner, Ana Silvia S. Marinonio, Milton H. Miyoshi, Paulo Bandiera-Paiva, Rosa M. V. Freitas, Liliam C. C. Morais, Monica L. P. Teixeira, Bernadette Waldvogel, Carlos Roberto V. Kiffer, Ruth Guinsburg
Summary: This study analyzed the temporal trend, causes, and timing of neonatal mortality of moderate and late preterm infants in Sao Paulo State, Brazil from 2004-2015. The results showed a decrease in neonatal mortality rate over the past decade, but highlighted the need for improvement in perinatal healthcare.
Letter
Nutrition & Dietetics
Heitor Pons Leite, Paulo Cesar Koch
CLINICAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Tais Thomsen Silveira, Danielly Oberoffer Stefenon, Emilio Lopes Junior, Tulio Konstantyner, Heitor Pons Leite, Yara Maria Franco Moreno
Summary: This systematic review investigated the concentrations of zinc (Zn), copper (Cu), and selenium (Se) in patients with systemic inflammatory response syndrome (SIRS) and their relationship with morbidity and mortality. The results showed that there were lower levels of Zn, Se, and Cu in the plasma/serum of SIRS patients compared to controls, and deficiencies in Zn and Se were associated with organ dysfunction, mortality, and inflammation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Pediatrics
Gabriella Mafra Elia, Tulio Konstantyner, Rafaela Pilotto Nais, Andreia Regina Augusto dos Santos, Andrea Angel, Josefina Aparecida Pellegrini Braga
Summary: This study aimed to compare clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2, and to compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission. Data from 57 pediatric patients with sickle cell disease hospitalized in a Brazilian academic hospital were collected, and 11 (19.3%) tested positive for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities and a decrease in eosinophil count between hospital admission and the last medical appointment.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Public, Environmental & Occupational Health
Eliana Pereira Vellozo, Maria Sylvia de Souza Vitalle, Maria Aparecida Zanetti Passos, Sheila Rejane Niskier, Teresa Helena Schoen, Peter Richard Hall, Francisco Placido Nogueira Arcanjo, Roberto Fernandes da Costa, Benjamin Israel Kopelman, Tulio Konstantyner
Summary: This cross-sectional study aimed to estimate the prevalence of psychoactive substance use among adolescents from public schools in a municipality in Brazil. The study collected information on demographic, socioeconomic, and drug use through self-report questionnaires. The results showed high prevalence rates of substance use, with analgesics and alcohol being the most commonly used substances.
CADERNOS DE SAUDE PUBLICA
(2023)
Article
Pediatrics
Beatriz Cassaniga Talassi, Tulio Konstantyner, Stela de Almeida Miranda, Heitor Pons Leite
Summary: The study aimed to describe weight and height evolution and identify risk factors for insufficient anthropometric growth in children with congenital heart disease. The results showed that being aged less than or equal to 12 months, having the lowest number of appointments, not having undergone surgical treatment, and having low family income were risk factors for insufficient weight and height gain.
REVISTA PAULISTA DE PEDIATRIA
(2022)
Article
Public, Environmental & Occupational Health
Rodrigo de Eston Armond, Jane de Eston Armond, Tulio Konstantyner, Cintia Leci Rodrigues
Summary: This study investigated the association between spiritual well-being and coronary artery disease. The results showed that there was no significant correlation between levels of spiritual, religious, and existential well-being and coronary artery disease.
JOURNAL OF RELIGION & HEALTH
(2022)