PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus

(2018) Stefanie Hardt et al.   Aging and Disease

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

(2017) Toshiyuki Imasawa et al.   FASEB JOURNAL

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

EphA2 is a functional receptor for the growth factor progranulin

(2016) Thomas Neill et al.   JOURNAL OF CELL BIOLOGY

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

(2016) Christine Altmann et al.   NEUROBIOLOGY OF DISEASE

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy

(2016) J Liu et al.   Cell Death & Disease

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

The role of progranulin in diabetes and kidney disease

(2015) Bruna Bellincanta Nicoletto et al.   Diabetology & Metabolic Syndrome

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury

(2013) Dong Zhou et al.   KIDNEY INTERNATIONAL

Autophagy: Emerging Therapeutic Target for Diabetic Nephropathy

(2013) Shinji Kume et al.   SEMINARS IN NEPHROLOGY

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury

(2012) Yanggang Yuan et al.   KIDNEY INTERNATIONAL

Receptor-Mediated Endocytosis of α-Galactosidase A in Human Podocytes in Fabry Disease

(2011) Thaneas Prabakaran et al.   PLoS One

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Sirtuins and Their Relevance to the Kidney

(2010) C.-M. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

The Mesangial Cell Revisited: No Cell Is an Island

(2009) D. Schlondorff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA