Mitochondria in Sepsis-Induced AKI

Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis-Induced Acute Kidney Injury

(2018) Qiongyuan Hu et al.   Oxidative Medicine and Cellular Longevity

Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation

(2018) Victoria R. Pell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

(2018) Ali Poyan Mehr et al.   NATURE MEDICINE

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal perfusion in sepsis: from macro- to microcirculation

(2017) Emiel Hendrik Post et al.   KIDNEY INTERNATIONAL

Metabolic reprogramming and tolerance during sepsis-induced AKI

(2017) Hernando Gómez et al.   Nature Reviews Nephrology

Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases

(2017) Tetsuro Matsuhashi et al.   EBioMedicine

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive PatientsNovelty and Significance

(2016) Alfonso Eirin et al.   HYPERTENSION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Defective postreperfusion metabolic recovery directly associates with incident delayed graft function

(2016) Leonie G.M. Wijermars et al.   KIDNEY INTERNATIONAL

Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury

(2016) Yugeesh R. Lankadeva et al.   KIDNEY INTERNATIONAL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

(2015) Jean-Paul Decuypere et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Erratum: AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2015) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury

(2015) Paolo Calzavacca et al.   CRITICAL CARE MEDICINE

Protective Effects of Antioxidant Peptide SS-31 Against Multiple Organ Dysfunctions During Endotoxemia

(2015) Guoming Li et al.   INFLAMMATION

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

(2015) Daniel A. Escobar et al.   JOURNAL OF SURGICAL RESEARCH

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

(2015) T. Suzuki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury

(2015) Ryan M. Whitaker et al.   KIDNEY INTERNATIONAL

Mitochondrial Function and Disturbances in the Septic Kidney

(2015) Samir M. Parikh et al.   SEMINARS IN NEPHROLOGY

Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models

(2015) Jing Cui et al.   Scientific Reports

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury

(2014) C. Quoilin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

(2014) A. S. Gonzalez et al.   FREE RADICAL RESEARCH

Formoterol Restores Mitochondrial and Renal Function after Ischemia-Reperfusion Injury

(2014) S. R. Jesinkey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Staphylococcus aureus Sepsis Induces Early Renal Mitochondrial DNA Repair and Mitochondrial Biogenesis in Mice

(2014) Raquel R. Bartz et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion

(2013) Roberto Teruya et al.   Acta Cirurgica Brasileira

Test Driving Levosimendan as the New “Kidney Protector”

(2013) Ann K. Gamilla-Crudo et al.   CRITICAL CARE MEDICINE

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation

(2013) Wan-Xin Tang et al.   JOURNAL OF NEPHROLOGY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

'Biologic memory' in response to acute kidney injury: cytoresistance, toll-like receptor hyper-responsiveness * and the onset of progressive renal disease

(2013) R. A. Zager   NEPHROLOGY DIALYSIS TRANSPLANTATION

Autophagy in Acute Kidney Injury

(2013) Man J. Livingston et al.   SEMINARS IN NEPHROLOGY

Mitochondrial Thiols in the Regulation of Cell Death Pathways

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury

(2012) Shunsaku Nakagawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sirolimus Prevents Short-Term Renal Changes Induced by Ischemia-Reperfusion Injury in Rats

(2011) C. Esposito et al.   AMERICAN JOURNAL OF NEPHROLOGY

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

(2011) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice

(2010) Julien Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of sepsis and sepsis-induced kidney injury

(2009) Kent Doi et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA