PGC-1α, glucose metabolism and type 2 diabetes mellitus

Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response

(2015) Xinlei Yu et al.   FASEB JOURNAL

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

(2015) Sasidharan Padmaja Divya et al.   TOXICOLOGICAL SCIENCES

Type 2 diabetes mellitus development programs in the new regulatory environment with cardiovascular safety requirements

(2015) Fred Yang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

C-C Chemokine Receptor 2 Inhibitor Ameliorates Hepatic Steatosis by Improving ER Stress and Inflammation in a Type 2 Diabetic Mouse Model

(2015) Hong-Min Kim et al.   PLoS One

Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling

(2015) Kaifeng Guo et al.   PLoS One

Preventative Effect ofZingiber officinaleon Insulin Resistance in a High-Fat High-Carbohydrate Diet-Fed Rat Model and its Mechanism of Action

(2014) Yiming Li et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes

(2014) Rahul Agrawal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions

(2014) Sanna-Mari Aatsinki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes

(2014) Naoki Sawada et al.   Cell Metabolism

PGC-1α Induces SPP1 to Activate Macrophages and Orchestrate Functional Angiogenesis in Skeletal Muscle

(2014) Glenn C. Rowe et al.   CIRCULATION RESEARCH

Vanin-1 Is a Key Activator for Hepatic Gluconeogenesis

(2014) Siyu Chen et al.   DIABETES

Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin

(2014) S. Gao et al.   DIABETES

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism

(2014) Marcin Buler et al.   FASEB JOURNAL

Effects of eugenol on hepatic glucose production and AMPK signaling pathway in hepatocytes and C57BL/6J mice

(2014) Kyong Ju Jeong et al.   FITOTERAPIA

Molecular Mechanisms for the Regulation of Insulin-Stimulated Glucose Uptake by Small Guanosine Triphosphatases in Skeletal Muscle and Adipocytes

(2014) Takaya Satoh   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats

(2014) Masataka Suwa et al.   Journal of Physiological Sciences

Selenium-enriched exopolysaccharides improve skeletal muscle glucose uptake of diabetic KKAy mice via AMPK pathway

(2014) Xihong Zhou et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1 /Liver-Specific PGC-1  Upregulation

(2014) W. Yao et al.   JOURNAL OF VIROLOGY

The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions

(2014) M.F.P. Silvestre et al.   LIFE SCIENCES

PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy

(2014) Joungil Choi et al.   NEUROBIOLOGY OF DISEASE

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

(2014) Yu Ah Hong et al.   PLoS One

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

(2014) Kimberly A. Negrin et al.   PLoS One

Targeting PGC-1α to Overcome the Harmful Effects of Glucocorticoids in Porcine Neonatal Pancreas Cell Clusters

(2014) Ji-Won Kim et al.   TRANSPLANTATION

Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-γ coactivator 1α in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats

(2014) Lei Bao et al.   Food & Function

Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

(2013) Geng Tian et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase Mimic Ebselen Improves Glucose-Stimulated Insulin Secretion in Murine Islets

(2013) Xinhui Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome

(2013) Fahed Parvaiz et al.   ARCHIVES OF VIROLOGY

Relationship of PGC-1α Gene Polymorphism With Insulin Resistance Syndrome in Korean Children

(2013) Chang-Duk Ha et al.   Asia-Pacific Journal of Public Health

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart

(2013) Wenjun Yan et al.   BASIC RESEARCH IN CARDIOLOGY

Sequential signaling cascade of IL-6 and PGC-1α is involved in high glucose-induced podocyte loss and growth arrest

(2013) Dong Il Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

(2013) L. Xiao et al.   DIABETES

Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells

(2013) Yoon Sin Oh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes

(2013) Amélie Rodrigue-Way et al.   FASEB JOURNAL

Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice

(2013) Wei-Hsuan Hsu et al.   FOOD AND CHEMICAL TOXICOLOGY

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells

(2013) Gholamreza Taheripak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of oxidative stress in impaired insulin signaling associated with exercise-induced muscle damage

(2013) Wataru Aoi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2

(2013) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation

(2013) Li Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats

(2013) Junyong Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mulberry Anthocyanins Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance

(2013) Jia-Jen Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes

(2013) An Yu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes

(2013) Flávia Gerelli Ghiraldini et al.   MOLECULAR BIOLOGY OF THE CELL

SIRT1 is a Direct Coactivator of Thyroid Hormone Receptor β1 with Gene-Specific Actions

(2013) Ji Ho Suh et al.   PLoS One

Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress

(2012) Xin Wang et al.   BIOCHIMIE

Glucocorticoid treatment independently affects expansion and transdifferentiation of porcine neonatal pancreas cell clusters

(2012) Ji-Won Kim et al.   BMB Reports

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1

(2012) Matthew M. Molusky et al.   DIABETES

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

Orphan Nuclear Receptor Estrogen-Related Receptor γ (ERRγ) Is Key Regulator of Hepatic Gluconeogenesis

(2012) Don-Kyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Phosphoenolpyruvate Carboxykinase Gene Expression and Steatosis during Hepatitis C Virus Subgenome Replication

(2012) Ishtiaq Qadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Sirtuin 1 in the Regulation of Hepatic Gene Expression by Thyroid Hormone

(2012) Shalini Thakran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance

(2012) Amir Shlomai et al.   JOURNAL OF HEPATOLOGY

MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis

(2012) Jichao Liang et al.   JOURNAL OF HEPATOLOGY

Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis

(2012) Ming Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet

(2012) Goiuri Alberdi et al.   NUTRITION

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

(2012) Emma Mormeneo et al.   PLoS One

Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

(2012) Marcin Buler et al.   PLoS One

Peroxisomal Localization and Circadian Regulation of Ubiquitin-Specific Protease 2

(2012) Matthew M. Molusky et al.   PLoS One

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

(2011) Andrew Philp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

DAX1 suppresses FXR transactivity as a novel co-repressor

(2011) Jin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Active Part ofArtemisia sacrorumLedeb. Suppresses Gluconeogenesis through AMPK Mediated GSK3β and CREB Phosphorylation in Human HepG2 Cells

(2011) Hai-Dan YUAN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Consumption of Soy Protein Isolate Reduces Hepatic SREBP-1c and Lipogenic Gene Expression in Wild-Type Mice, but Not in FXR-Deficient Mice

(2011) Tsutomu HASHIDUME et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

(2011) Andreas L. Birkenfeld et al.   Cell Metabolism

Contribution of Endogenous Inhibitor of Nitric Oxide Synthase to Hepatic Mitochondrial Dysfunction in Streptozotocin-induced Diabetic Rats

(2011) Na Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells

(2011) Hai-Dan Yuan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway

(2011) C. Zhang et al.   DIABETOLOGIA

Beta-cell injury in Ncb5or-null mice is exacerbated by consumption of a high-fat diet

(2011) Ying Guo et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1–7)masreceptor expression associated with its PPAR-γ agonist action

(2011) Arun Prasath Lakshmanan et al.   FREE RADICAL RESEARCH

Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression

(2011) Annelies Peeters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen-related Receptor γ (ERRγ) Is a Novel Transcriptional Regulator of Phosphatidic Acid Phosphatase, LIPIN1, and Inhibits Hepatic Insulin Signaling

(2011) Don-Kyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver

(2011) Marcin Buler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Novel Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Isoform in Human Liver

(2011) Thomas K. Felder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1 

(2011) F. B. Hickey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Insulin Sensitizing Effects of Oligomannuronate-Chromium (III) Complexes in C2C12 Skeletal Muscle Cells

(2011) Cui Hao et al.   PLoS One

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase

(2010) Liu-Luan Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

(2010) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fine-tuned regulation of the PGC-1α gene transcription by different intracellular signaling pathways

(2010) Tao Hong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

cAMP-mediated regulation of HNF-4α depends on the level of coactivator PGC-1α

(2010) Simon Nitter Dankel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

(2010) Liang-Liang Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

(2010) B. Jafar-Mohammadi et al.   DIABETOLOGIA

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

(2010) C. R. Benton et al.   DIABETOLOGIA

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells

(2010) G. A. Raciti et al.   DIABETOLOGIA

Effects of the Peroxisome Proliferator Activated Receptor-γ Coactivator-1α(PGC-1α) Thr394ThrandGly482SerPolymorphisms on Rosiglitazone Response in Chinese Patients With Type 2 Diabetes Mellitus

(2010) Ke-Han Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Maternal malnutrition programs pancreatic islet mitochondrial dysfunction in the adult offspring

(2010) Nicolas Theys et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Activation of PPARδ promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated β-cells

(2010) Li Jiang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

(2009) B. Viollet et al.   Acta Physiologica

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

PGC-1α Gly482Ser Polymorphism Is Associated with the Plasma Adiponectin Level in Type 2 Diabetic Men

(2009) Yukiyoshi OKAUCHI et al.   ENDOCRINE JOURNAL

Multiple Binding Modes between HNF4α and the LXXLL Motifs of PGC-1α Lead to Full Activation

(2009) Geun Bae Rha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAX-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor HNF4α and Negatively Regulates Gluconeogenic Enzyme Gene Expression

(2009) Balachandar Nedumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

(2009) Ning Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR control: it's SIRTainly as easy as PGC

(2009) Mary C Sugden et al.   JOURNAL OF ENDOCRINOLOGY

α-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate–activated protein kinase–peroxisome proliferator-activated receptor-γ coactivator-1α signaling in the skeletal muscle of aged mice

(2009) Yi Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genome-wide Coactivation Analysis of PGC-1α Identifies BAF60a as a Regulator of Hepatic Lipid Metabolism

(2008) Siming Li et al.   Cell Metabolism

Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1α gene

(2008) Estibaliz Goyenechea et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1α

(2008) M. M. Schilling et al.   DIABETOLOGIA

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Nuclear Respiratory Factor 1 Controls Myocyte Enhancer Factor 2A Transcription to Provide a Mechanism for Coordinate Expression of Respiratory Chain Subunits

(2008) Bindu Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Coactivator PGC-1α regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes

(2008) Satu Arpiainen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY