Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

(2019) Jun-Ha Hwang et al.   Nature Communications

Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis

(2019) Jinglin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Force Transmission between Three Tissues Controls Bipolar Planar Polarity Establishment and Morphogenesis

(2019) Ghislain Gillard et al.   CURRENT BIOLOGY

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

(2019) David Merrick et al.   SCIENCE

Regulated Activation of the PAR Polarity Network Ensures a Timely and Specific Response to Spatial Cues

(2019) Jacob D. Reich et al.   CURRENT BIOLOGY

The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans

(2019) Hanee Lee et al.   GENETICS

TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

(2019) Dalila El Ouarrat et al.   Cell Metabolism

Inhibition of Piezo1 attenuates demyelination in the central nervous system

(2019) María Velasco‐Estevez et al.   GLIA

LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway

(2019) Kun Qiao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions

(2019) Clémentine Villeneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth

(2019) Nerea Borreguero-Muñoz et al.   PLOS BIOLOGY

Autophagy promotes triple negative breast cancer metastasis via YAP nuclear localization

(2019) Wei Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emerging technologies in mechanotransduction research

(2019) Ghaidan A Shamsan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of mechanical cues in shaping neuronal morphology and connectivity

(2018) Girisaran Gangatharan et al.   BIOLOGY OF THE CELL

Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues

(2018) Kevin M. Tharp et al.   Cell Metabolism

Evolution of mechanotransduction via YAP/TAZ in animal epithelia

(2018) Ahmed Elbediwy et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanical strain regulates the Hippo pathway in Drosophila

(2018) Georgina C. Fletcher et al.   DEVELOPMENT

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

Liraglutide suppresses proliferation and induces adipogenic differentiation of 3T3-L1 cells via the Hippo-YAP signaling pathway

(2018) Yongmei Li et al.   Molecular Medicine Reports

Aging and ocular tissue stiffness in glaucoma

(2018) Baiyun Liu et al.   SURVEY OF OPHTHALMOLOGY

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

(2018) Amin Ardestani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Talin2 regulates breast cancer cell migration and invasion by apoptosis

(2018) Yingfan Liang et al.   Oncology Letters

Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

(2018) Liqun Wang et al.   Nature Communications

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export

(2018) Nil Ege et al.   Cell Systems

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells

(2018) Fengbo Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

(2018) Jie Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation

(2018) Krishna Chinthalapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

(2018) Kaly A. Mueller et al.   Scientific Reports

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

(2018) Yuyi You et al.   BRAIN

The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition

(2018) Shweta Sharma et al.   Cellular and Molecular Bioengineering

Enigma proteins regulate YAP mechanotransduction

(2018) Ahmed Elbediwy et al.   JOURNAL OF CELL SCIENCE

TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition

(2018) Shweta Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The obese adipose tissue microenvironment in cancer development and progression

(2018) Daniela F. Quail et al.   Nature Reviews Endocrinology

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

(2018) María Velasco-Estevez et al.   Frontiers in Aging Neuroscience

Transcriptional integration of mitogenic and mechanical signals by Myc and YAP

(2017) Ottavio Croci et al.   GENES & DEVELOPMENT

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

(2017) Pei-Jie Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment

(2017) Chelsea Hepler et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization

(2017) Shyi-Chyi Wang et al.   NATURE CELL BIOLOGY

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

(2017) Yanhui Zhang et al.   NATURE CELL BIOLOGY

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

YAP-mediated mechanotransduction determines the podocyte’s response to damage

(2017) Markus M. Rinschen et al.   Science Signaling

Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway

(2017) Hai-Jun Li et al.   Oncology Letters

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

(2017) Kyota Fujita et al.   Nature Communications

The soft mechanical signature of glial scars in the central nervous system

(2017) Emad Moeendarbary et al.   Nature Communications

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

The role of talin2 in breast cancer tumorigenesis and metastasis

(2017) Liqing Li et al.   Oncotarget

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

(2017) Sayan Chakraborty et al.   Cell Reports

YAP-mediated mechanotransduction determines the podocyte’s response to damage

(2017) Markus M. Rinschen et al.   Science Signaling

The emerging role of YAP/TAZ in mechanotransduction

(2017) Zahra Mohri et al.   Journal of Thoracic Disease

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Talin: a mechanosensitive molecule in health and disease

(2016) Alexander W. M. Haining et al.   FASEB JOURNAL

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Talin2-mediated traction force drives matrix degradation and cell invasion

(2016) Lei Qi et al.   JOURNAL OF CELL SCIENCE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

Regional brain stiffness changes across the Alzheimer's disease spectrum

(2016) Matthew C. Murphy et al.   NeuroImage-Clinical

Mechanotransduction in cancer

(2016) LiKang Chin et al.   Current Opinion in Chemical Engineering

Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos

(2015) Yoshikazu Hirate et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition

(2015) Houari Abdesselem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

(2015) Andrew Archibald et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos

(2015) Hiroshi Sasaki   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Axoplasmic reticulum Ca2+release causes secondary degeneration of spinal axons

(2014) David P. Stirling et al.   ANNALS OF NEUROLOGY

Adipocyte Stiffness Increases with Accumulation of Lipid Droplets

(2014) Naama Shoham et al.   BIOPHYSICAL JOURNAL

Mechanical Checkpoint For Persistent Cell Polarization In Adhesion-Naive Fibroblasts

(2014) Philippe Bun et al.   BIOPHYSICAL JOURNAL

A Critical Pull to Polarize the Cell

(2014) Arupratan Das   BIOPHYSICAL JOURNAL

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Human adipocyte function is impacted by mechanical cues

(2014) V Pellegrinelli et al.   JOURNAL OF PATHOLOGY

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

(2014) Maureen Cetera et al.   Nature Communications

Atypical Protein Kinase Cι as a human oncogene and therapeutic target

(2013) Peter J. Parker et al.   BIOCHEMICAL PHARMACOLOGY

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells

(2013) Jean-Cheng Kuo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanotransduction at focal adhesions: from physiology to cancer development

(2013) Jihye Seong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functional TRPV and TRPM channels in human preadipocytes

(2013) Hui Che et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cancer-Associated Mutation in Atypical Protein Kinase C  Occurs in a Substrate-Specific Recruitment Motif

(2013) M. Linch et al.   Science Signaling

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell polarity: mechanochemical patterning

(2012) Nathan W. Goehring et al.   TRENDS IN CELL BIOLOGY

Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway

(2011) Naama Shoham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction in adipocytes

(2011) Naama Shoham et al.   JOURNAL OF BIOMECHANICS

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Dynamics of human adipose lipid turnover in health and metabolic disease

(2011) Peter Arner et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division

(2011) Matilde Galli et al.   NATURE CELL BIOLOGY

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

(2011) Buer Sen et al.   STEM CELLS

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

(2010) Darren L. Roberts et al.   Annual Review of Medicine

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

(2010) Roland Baumgartner et al.   DEVELOPMENTAL CELL

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperechogenicity of the substantia nigra: pitfalls in assessment and specificity for Parkinson’s disease

(2010) Daniela Berg   JOURNAL OF NEURAL TRANSMISSION

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear Stress Induced Reorganization of the Keratin Intermediate Filament Network Requires Phosphorylation by Protein Kinase C ζ

(2009) Sivaraj Sivaramakrishnan et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES