The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth

Evolution of mechanotransduction via YAP/TAZ in animal epithelia

(2018) Ahmed Elbediwy et al.   CURRENT OPINION IN CELL BIOLOGY

Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped -based genetic epistasis

(2018) Jianzhong Yu et al.   DEVELOPMENT

Mechanical strain regulates the Hippo pathway in Drosophila

(2018) Georgina C. Fletcher et al.   DEVELOPMENT

YAP and TAZ are essential for basal and squamous cell carcinoma initiation

(2018) Maud Debaugnies et al.   EMBO REPORTS

Tension-dependent regulation of mammalian Hippo signaling through LIMD1

(2018) Consuelo Ibar et al.   JOURNAL OF CELL SCIENCE

FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction

(2018) Katarzyna Nowak et al.   PLoS Genetics

The dynamics of hippo signaling during Drosophila wing development

(2018) Yuanwang Pan et al.   DEVELOPMENT

YAP drives cutaneous squamous cell carcinoma formation and progression

(2018) Zoé Vincent-Mistiaen et al.   eLife

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

(2017) Hiba Sabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary

(2017) Ta-Hsing Hsu et al.   Scientific Reports

YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage

(2016) Ahmed Elbediwy et al.   BIOESSAYS

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor

(2016) Grinu Mathew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential growth triggers mechanical feedback that elevates Hippo signaling

(2016) Yuanwang Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

(2015) Naomi C. Mitchell et al.   CELLULAR SIGNALLING

Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers

(2015) K. Mahala Burn et al.   DEVELOPMENTAL BIOLOGY

The Spectrin cytoskeleton regulates the Hippo signalling pathway

(2015) G. C. Fletcher et al.   EMBO JOURNAL

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Cell mixing induced by myc is required for competitive tissue invasion and destruction

(2015) Romain Levayer et al.   NATURE

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie

(2015) Joseph Parker et al.   PLOS BIOLOGY

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

(2014) David Romano et al.   NATURE CELL BIOLOGY

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

(2014) Bruce A. Edgar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch Inhibits Yorkie Activity in Drosophila Wing Discs

(2014) Alexandre Djiane et al.   PLoS One

Tight Coordination of Growth and Differentiation between Germline and Soma Provides Robustness for Drosophila Egg Development

(2014) Caroline Vachias et al.   Cell Reports

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics

(2013) David Romano et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size

(2012) T. Aegerter-Wilmsen et al.   DEVELOPMENT

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

(2012) Katrin Straßburger et al.   DEVELOPMENTAL BIOLOGY

DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway

(2012) L.E. Killip et al.   DEVELOPMENTAL BIOLOGY

Tissue-Specific Coupling between Insulin/IGF and TORC1 Signaling via PRAS40 in Drosophila

(2012) Cristina Pallares-Cartes et al.   DEVELOPMENTAL CELL

Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth inDrosophila

(2012) Lynne Marshall et al.   EMBO JOURNAL

Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling

(2012) E. J. Rideout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Pathway

(2012) K. F. Harvey et al.   Cold Spring Harbor Perspectives in Biology

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis

(2011) Hsi-Ju Chen et al.   DEVELOPMENTAL BIOLOGY

Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

(2011) David Matallanas et al.   MOLECULAR CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt

(2010) D. Romano et al.   CANCER RESEARCH

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Developmental control of cell growth and division in Drosophila

(2010) Barry J Thompson   CURRENT OPINION IN CELL BIOLOGY

Exploring the effects of mechanical feedback on epithelial topology

(2010) T. Aegerter-Wilmsen et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

(2010) Lutz Kockel et al.   PLoS Genetics

Regulation of Tissue Growth through Nutrient Sensing

(2009) Ville Hietakangas et al.   Annual Review of Genetics

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

(2009) Fangfang Ren et al.   DEVELOPMENTAL BIOLOGY

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

β1 Integrin-Mediated Adhesion Signalling Is Essential for Epidermal Progenitor Cell Expansion

(2009) Aleksandra Piwko-Czuchra et al.   PLoS One

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

(2008) Aurelio A. Teleman et al.   Cell Metabolism

Drosophila oogenesis

(2008) Rebecca Bastock et al.   CURRENT BIOLOGY

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

(2008) Youlian Goulev et al.   CURRENT BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling

(2008) Jianjun Sun et al.   JOURNAL OF CELL BIOLOGY