Inhibition of Piezo1 attenuates demyelination in the central nervous system

Piezo1 mediates neuron oxygen-glucose deprivation/reoxygenation injury via Ca2+/calpain signaling

(2019) Ying-Ying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Piezo1 regulates calcium oscillations and cytokine release from astrocytes

(2019) María Velasco‐Estevez et al.   GLIA

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation

(2018) Elizabeth L Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

GsMTx4-D Provides Protection to the D2. mdx Model of DMD

(2018) Christopher W. Ward et al.   NEUROMUSCULAR DISORDERS

Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

(2018) Jerome J. Lacroix et al.   Nature Communications

Regulation of Neuronal Cytoskeletal Protein Phosphorylation in Neurodegenerative Diseases

(2018) Parvathi Rudrabhatla   JOURNAL OF ALZHEIMERS DISEASE

The mechanosensitive Piezo1 channel: a three‐bladed propeller‐like structure and a lever‐like mechanogating mechanism

(2018) Qiancheng Zhao et al.   FEBS Journal

The Rules of Attraction in Central Nervous System Myelination

(2018) Rafael Góis Almeida   Frontiers in Cellular Neuroscience

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

(2018) María Velasco-Estevez et al.   Frontiers in Aging Neuroscience

Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy

(2017) Jason R. Plemel et al.   GLIA

Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors

(2017) Sinead A. O'Sullivan et al.   GLIA

Diffuse Axonal Injury and Oxidative Stress: A Comprehensive Review

(2017) Alessandro Frati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for shear-mediated Ca2+entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line

(2017) Zeki Ilkan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression

(2017) Anna Jagielska et al.   Frontiers in Cellular Neuroscience

Neurofilaments and Neurofilament Proteins in Health and Disease

(2017) Aidong Yuan et al.   Cold Spring Harbor Perspectives in Biology

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

(2017) Emmanuelle Berret et al.   Nature Communications

YAP/TAZ initiate and maintain Schwann cell myelination

(2017) Matthew Grove et al.   eLife

Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination

(2017) Cedric Misslin et al.   PLoS One

YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation

(2016) Takeshi Shimizu et al.   GLIA

GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion

(2016) Jinli Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Remodeling myelination: implications for mechanisms of neural plasticity

(2016) Kae-Jiun Chang et al.   NATURE NEUROSCIENCE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy

(2016) David G. Allen et al.   PHYSIOLOGICAL REVIEWS

Modulation of Oligodendrocyte Differentiation by Mechanotransduction

(2016) Tânia Lourenço et al.   Frontiers in Cellular Neuroscience

Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

(2016) Ruani N. Fernando et al.   Nature Communications

Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues

(2016) Tânia Lourenço et al.   Scientific Reports

Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling

(2015) C. O'Sullivan et al.   JOURNAL OF CELL SCIENCE

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity

(2015) Magdalena Kocur et al.   Acta Neuropathologica Communications

Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels

(2015) Radhakrishnan Gnanasambandam et al.   PLoS One

Axoplasmic reticulum Ca2+release causes secondary degeneration of spinal axons

(2014) David P. Stirling et al.   ANNALS OF NEUROLOGY

A unified cell biological perspective on axon–myelin injury

(2014) Mikael Simons et al.   JOURNAL OF CELL BIOLOGY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels

(2014) Nils R. Blumenthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Focal Increases of Axoplasmic Ca2+, Aggregation of Sodium-Calcium Exchanger, N-type Ca2+ Channel, and Actin Define the Sites of Spheroids in Axons Undergoing Oxidative Stress

(2012) A. G. Barsukova et al.   JOURNAL OF NEUROSCIENCE

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Neurofilament protein levels: Quantitative analysis in essential tremor cerebellar cortex

(2012) Elan D. Louis et al.   NEUROSCIENCE LETTERS

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

(2012) Brian J. McHugh et al.   PLoS One

Mechanical Environment Modulates Biological Properties of Oligodendrocyte Progenitor Cells

(2012) Anna Jagielska et al.   STEM CELLS AND DEVELOPMENT

Axonopathy is a compounding factor in the pathogenesis of Krabbe disease

(2011) Ludovico Cantuti Castelvetri et al.   ACTA NEUROPATHOLOGICA

Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products of the Myelin Basic Protein Gene

(2011) P. M. Paez et al.   JOURNAL OF NEUROSCIENCE

KV7/KCNQ Channels Are Functionally Expressed in Oligodendrocyte Progenitor Cells

(2011) Wei Wang et al.   PLoS One

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+and K+Ion Channels

(2009) Elisa Redaelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

(2009) B. J. McHugh et al.   JOURNAL OF CELL SCIENCE

Combined hematopoietic and lentiviral gene-transfer therapies in newborn Twitcher mice reveal contemporaneous neurodegeneration and demyelination in Krabbe disease

(2009) F. Galbiati et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

(2009) Maren Lindner et al.   NEUROSCIENCE LETTERS

Reactive Astrocytes in Glial Scar Attract Olfactory Ensheathing Cells Migration by Secreted TNF-α in Spinal Cord Lesion of Rat

(2009) Zhida Su et al.   PLoS One

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Calcium ions in neuronal degeneration

(2008) Urszula Wojda et al.   IUBMB LIFE

The Role of Calcium-Activated Protease Calpain in Experimental Retinal Pathology

(2008) M. Azuma et al.   SURVEY OF OPHTHALMOLOGY