The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

(2018) Krishna Chinthalapudi et al.   Nature Communications

Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites

(2016) Tina Izard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization

(2016) Krishna Chinthalapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dual structural roles of the membrane distal region of the  -integrin cytoplasmic tail during integrin inside-out activation

(2015) J. Liu et al.   JOURNAL OF CELL SCIENCE

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Vinculin-cell membrane interactions

(2015) David T. Brown et al.   Oncotarget

Lipid binding promotes oligomerization and focal adhesion activity of vinculin

(2014) Krishna Chinthalapudi et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling

(2013) Yue Sun et al.   BIOESSAYS

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin

(2012) S. D. Yogesha et al.   PROTEIN SCIENCE

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Affinity of talin-1 for the  3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

(2011) D. T. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin

(2011) S. D. Yogesha et al.   PROTEIN SCIENCE

The tail of integrin activation

(2011) Nicholas J. Anthis et al.   TRENDS IN BIOCHEMICAL SCIENCES

One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane

(2010) Katarzyna Kwiatkowska   CELLULAR AND MOLECULAR LIFE SCIENCES

Translation of the phosphoinositide code by PI effectors

(2010) Tatiana G Kutateladze   Nature Chemical Biology

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

(2009) I. van den Bout et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL