FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

YAP-mediated mechanotransduction determines the podocyte’s response to damage

(2017) Markus M. Rinschen et al.   Science Signaling

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

(2017) Sayan Chakraborty et al.   Cell Reports

YAP-mediated mechanotransduction determines the podocyte’s response to damage

(2017) Markus M. Rinschen et al.   Science Signaling

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

A Computational Model of YAP/TAZ Mechanosensing

(2016) Meng Sun et al.   BIOPHYSICAL JOURNAL

Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation

(2016) Ying-Wei Li et al.   CELL CYCLE

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Front–Rear Polarization by Mechanical Cues: From Single Cells to Tissues

(2016) Benoit Ladoux et al.   TRENDS IN CELL BIOLOGY

Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment

(2016) Simon J. Attwood et al.   Scientific Reports

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

(2015) Andrew M Handorf et al.   Organogenesis

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever

(2014) Vinicio Carloni et al.   LIVER INTERNATIONAL

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells

(2013) Sara M. Thomasy et al.   EXPERIMENTAL EYE RESEARCH

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Experimental validation of atomic force microscopy-based cell elasticity measurements

(2011) Andrew R Harris et al.   NANOTECHNOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Fibrogenic signalling in hepatic stellate cells

(2010) Derek A. Mann et al.   JOURNAL OF HEPATOLOGY

Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines

(2009) X. Zhang et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Focal Adhesion Kinase Modulates Cell Adhesion Strengthening via Integrin Activation

(2009) Kristin E. Michael et al.   MOLECULAR BIOLOGY OF THE CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

(2008) Vita M. Golubovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY