Talin: a mechanosensitive molecule in health and disease

Rap1 and its effector RIAM are required for lymphocyte trafficking

(2015) W. Su et al.   BLOOD

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma

(2015) Ya-Fei Xu et al.   BMC CANCER

MiR-124 suppresses cell motility and adhesion by targeting talin 1 in prostate cancer cells

(2015) Wei Zhang et al.   Cancer Cell International

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

PIP2 and Talin Join Forces to Activate Integrin

(2015) Adam Orłowski et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Talin determines the nanoscale architecture of focal adhesions

(2015) Jaron Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

(2015) Schammim Ray Amith et al.   Oncotarget

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions

(2014) Hiroaki Hirata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading

(2014) Shelly Kaushik et al.   Cytoskeleton

Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

(2014) Brian T. Beaty et al.   JOURNAL OF CELL BIOLOGY

The role of the interaction of the vinculin proline-rich linker region with vinexin   in sensing the stiffness of the extracellular matrix

(2014) H. Yamashita et al.   JOURNAL OF CELL SCIENCE

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance

(2014) Xuefei Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

(2014) A. P. Andersen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Novel Pharmacologic Targeting of Tight Junctions and Focal Adhesions in Prostate Cancer Cells

(2014) Patrick J. Hensley et al.   PLoS One

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Talin and kindlin: the one-two punch in integrin activation

(2014) Feng Ye et al.   Frontiers of Medicine

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics

(2013) Radoslav Janoštiak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer

(2013) S. M. Singel et al.   CLINICAL CANCER RESEARCH

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1

(2013) HAOSHA TANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility

(2013) ANNE-KRISTIN VAHLE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3

(2013) Caterina Casari et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes

(2013) Julia Fröbel et al.   MOLECULAR & CELLULAR PROTEOMICS

Two modes of integrin activation form a binary molecular switch in adhesion maturation

(2013) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Constitutively Activated β 1 Integrins Inhibits Prostate Cancer Metastasis

(2013) Yu-Chen Lee et al.   MOLECULAR CANCER RESEARCH

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

(2013) MARIA RAFFAELLA GRECO et al.   ONCOLOGY REPORTS

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

(2012) Emmanuel Debrand et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2

(2012) Uta Praekelt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

(2012) Zala Jevnikar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin activates integrins by altering the topology of the β transmembrane domain

(2012) Chungho Kim et al.   JOURNAL OF CELL BIOLOGY

DNA methylation silences miR-132 in prostate cancer

(2012) A Formosa et al.   ONCOGENE

Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer

(2012) Xiao-Feng Le et al.   PLoS One

Chemokines and the Signaling Modules Regulating Integrin Affinity

(2012) Alessio Montresor et al.   Frontiers in Immunology

Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance

(2011) Hope A. Sansing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spatiotemporal Constraints on the Force-Dependent Growth of Focal Adhesions

(2011) Jonathan Stricker et al.   BIOPHYSICAL JOURNAL

Talin-1 and Kindlin-3 Regulate α 4 β 1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation

(2011) Sharon J. Hyduk et al.   JOURNAL OF IMMUNOLOGY

Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis

(2011) Ming-Tsung Lai et al.   JOURNAL OF PATHOLOGY

Contributions of talin-1 to glioma cell-matrix tensional homeostasis

(2011) S. Sen et al.   Journal of the Royal Society Interface

Identification by Differential Tissue Proteome Analysis of Talin-1 as a Novel Molecular Marker of Progression of Hepatocellular Carcinoma

(2011) Hideaki Kanamori et al.   ONCOLOGY

Carcinoma Matrix Controls Resistance to Cisplatin through Talin Regulation of NF-kB

(2011) Karen E. Eberle et al.   PLoS One

Multiscale simulations suggest a mechanism for integrin inside-out activation

(2011) A. C. Kalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach

(2011) Jairam Vanamala et al.   Proteome Science

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Talin1 Promotes Tumor Invasion and Metastasis via Focal Adhesion Signaling and Anoikis Resistance

(2010) S. Sakamoto et al.   CANCER RESEARCH

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

(2010) Petra M. Kopp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

(2010) G. Lauritzen et al.   EXPERIMENTAL CELL RESEARCH

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells

(2008) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: record linkage study

(2008) Michael J. Goldacre et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Identification of a repeated domain within mammalian α-synemin that interacts directly with talin

(2008) Ning Sun et al.   EXPERIMENTAL CELL RESEARCH

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

(2008) W. Xue et al.   GENES & DEVELOPMENT

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology