Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

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MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRF Co-factors Control the Balance between Cell Proliferation and Contractility

(2016) Francesco Gualdrini et al.   MOLECULAR CELL

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

(2015) Joseph W. O'Connor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MRTF-A and YAP exert dual control in GPCR and RhoA-mediated transcriptional regulation and cell proliferation

(2015) Olivia Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

(2015) Fernando Calvo et al.   Cell Reports

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

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Integrin αv in the mechanical response of osteoblast lineage cells

(2014) Keiko Kaneko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

A high-resolution map of the three-dimensional chromatin interactome in human cells

(2013) Fulai Jin et al.   NATURE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

(2012) R. N. Judson et al.   JOURNAL OF CELL SCIENCE

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

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(2011) K.-I. Wada et al.   DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

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(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

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HER-2/neu expression/amplification is not stable during tumor progression. A single institution study with intrapatient comparisons years 1999 through to 2007.

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Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma

(2010) Kue Peng Lim et al.   JOURNAL OF PATHOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

(2009) Pierre Farmer et al.   NATURE MEDICINE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses

(2008) James E. Ferrell   CURRENT BIOLOGY

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

(2008) M. Ota et al.   DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT