DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

Oral Gavage of Ginger Nanoparticle-derived Lipid Vectors Loaded with Dmt1 siRNA Mitigates Iron Loading in Murine Hereditary Hemochromatosis

(2019) Xiaoyu Wang et al.   MOLECULAR THERAPY

Nitric Oxide, Iron and Neurodegeneration

(2019) Chao Liu et al.   Frontiers in Neuroscience

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

(2018) Ya-Shuo Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum

(2018) Hale Z. Toklu et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of NMDA receptors mediated iron accumulation via modulating iron transporters in Parkinson’s disease

(2018) Huamin Xu et al.   FASEB JOURNAL

Inflammation-induced iron transport and metabolism by brain microglia

(2018) Ryan C. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier

(2018) Brian Chiou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Higher serum levels of pro-hepcidin in patients with Parkinson’s disease treated with deep brain stimulation

(2018) J. Kwiatek-Majkusiak et al.   NEUROSCIENCE LETTERS

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

(2018) Natascha A. Wolff  et al.   Scientific Reports

Lower Expression of Ndfip1 Is Associated With Alzheimer Disease Pathogenesis Through Decreasing DMT1 Degradation and Increasing Iron Influx

(2018) Juan Tian et al.   Frontiers in Aging Neuroscience

S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit

(2018) Chao Liu et al.   JOURNAL OF NEUROSCIENCE

Non-transferrin-bound iron transporters

(2018) Mitchell D. Knutson   FREE RADICAL BIOLOGY AND MEDICINE

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases

(2018) Moussa B. H. Youdim   JOURNAL OF NEURAL TRANSMISSION

The Dual Role of Hepcidin in Brain Iron Load and Inflammation

(2018) Driton Vela   Frontiers in Neuroscience

Iron and infection

(2017) Tomas Ganz   INTERNATIONAL JOURNAL OF HEMATOLOGY

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia

(2017) Pamela J. Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Extending the aceruloplasminemia phenotype: NBIA on imaging and acanthocytosis, yet only minor neurological findings

(2017) Rebecca Kassubek et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain

(2017) Cheng-Wu Zhang et al.   NEUROMOLECULAR MEDICINE

Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis

(2017) Lin-Hao You et al.   Cell Death & Disease

Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism

(2017) Vanessa Porrini et al.   Frontiers in Aging Neuroscience

Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus

(2017) Nady Braidy et al.   Frontiers in Aging Neuroscience

Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease

(2017) Zohara Sternberg et al.   Aging and Disease

New Insights into the Crosstalk between NMDARs and Iron: Implications for Understanding Pathology of Neurological Diseases

(2017) Huamin Xu et al.   Frontiers in Molecular Neuroscience

Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

(2017) Yu-Fu Zhou et al.   Frontiers in Physiology

Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)

(2017) Rosaria Ingrassia et al.   Frontiers in Genetics

Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage

(2017) Yanjiang Li et al.   PLoS One

Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral HemorrhageClinical Perspective

(2016) Xiao-Yi Xiong et al.   CIRCULATION

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

(2016) Rachel S. White et al.   Molecular Brain

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

(2015) Dong Xian-hui et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier

(2015) Annette Burkhart et al.   MOLECULAR NEUROBIOLOGY

Ndfip1 attenuated 6-OHDA–induced iron accumulation via regulating the degradation of DMT1

(2015) Wenting Jia et al.   NEUROBIOLOGY OF AGING

Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism

(2015) Sonia Levi et al.   NEUROBIOLOGY OF DISEASE

Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

(2015) C. E. Arber et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

(2015) Chuang Guo et al.   Frontiers in Aging Neuroscience

Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

(2015) Tina Skjørringe et al.   Frontiers in Molecular Neuroscience

Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1

(2015) Goichi Beck et al.   PLoS One

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

(2014) Natascha A Wolff et al.   Channels

Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)

(2014) Natascha A. Wolff et al.   FASEB JOURNAL

Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

(2014) Fang Du et al.   MOLECULAR NEUROBIOLOGY

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

(2014) Scott Ayton et al.   Molecular Neurodegeneration

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden

(2013) Ilaria Pelizzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B

(2013) Huamin Xu et al.   BIOMETALS

Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress

(2013) Steven A. Bloomer et al.   BLOOD CELLS MOLECULES AND DISEASES

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice

(2013) Chia-Yu Wang et al.   HEPATOLOGY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease

(2013) X. Yu et al.   NEUROLOGY

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

(2012) Supak Jenkitkasemwong et al.   BIOMETALS

Late-onset Parkinsonism in NF B/c-Rel-deficient mice

(2012) C. Baiguera et al.   BRAIN

Tanshinone IIA Prevented Brain Iron Dyshomeostasis in Cerebral Ischemic Rats

(2012) Lei Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

(2012) Rosaria Ingrassia et al.   PLoS One

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Intranasal Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): A New Rodent Model to Test Palliative and Neuroprotective Agents for Parkinson's disease

(2011) Rui D. S. Prediger et al.   CURRENT PHARMACEUTICAL DESIGN

Intranasal delivery to the brain

(2011) Robert I Henkin   NATURE BIOTECHNOLOGY

A mucosal gateway for vaccines

(2011) Jerry R McGhee   NATURE BIOTECHNOLOGY

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

(2010) N. J. Foot et al.   BLOOD

Transient Expression of Iron Transport Proteins in the Capillary of the Developing Rat Brain

(2010) W. M. Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1

(2010) Dan Wang et al.   IUBMB LIFE

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1

(2010) M. Tabuchi et al.   JOURNAL OF CELL SCIENCE

Divalent metal transporter 1 is a hypoxia-inducible gene

(2010) Zhong-Ming Qian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy

(2010) Ana G Barbeito et al.   Molecular Neurodegeneration

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

(2010) A Lanzillotta et al.   Cell Death & Disease

High Cerebrospinal Fluid (CSF) Penetration and Potent Bactericidal Activity in CSF of NZ2114, a Novel Plectasin Variant, during Experimental Pneumococcal Meningitis

(2009) C. Ostergaard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The impact of host iron homeostasis on disease

(2009) James R. Connor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration

(2009) Wen Zhu et al.   NEUROBIOLOGY OF DISEASE

Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism

(2009) Jerome A. Roth   NEUROMOLECULAR MEDICINE

Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training

(2009) Paola Haeger et al.   NEUROTOXICITY RESEARCH

L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression

(2009) Fang Du et al.   PLoS One

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

(2009) J. Howitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA