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Title
Organic Cation Transporters in Health and Disease
Authors
Keywords
-
Journal
PHARMACOLOGICAL REVIEWS
Volume 72, Issue 1, Pages 253-319
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2019-12-19
DOI
10.1124/pr.118.015578
References
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- Molecular Mechanism of Renal Tubular Secretion of the Antimalarial Drug Chloroquine
- (2011) Fabian Müller et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease
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- OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
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- LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment
- (2011) A. Grabner et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Clinical Pharmacokinetics of Metformin
- (2011) Garry G. Graham et al. CLINICAL PHARMACOKINETICS
- Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug Tramadol
- (2011) M V Tzvetkov et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to Metformin
- (2011) J H Choi et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects
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- Overview of SLC22A and SLCO Families of Drug Uptake Transporters in the Context of Cancer Treatments
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- Metformin and digestive disorders
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- Rotenone, Paraquat, and Parkinson’s Disease
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- The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization
- (2011) Sabine Brast et al. FASEB JOURNAL
- Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review
- (2011) Gerald N. Wogan et al. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population
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- Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter
- (2011) Toshinori Komatsu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The Large Extracellular Loop of Organic Cation Transporter 1 Influences Substrate Affinity and Is Pivotal for Oligomerization
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- Organic Cation Transporter 3: Expression in Failing and Nonfailing Human Heart and Functional Characterization
- (2011) Thomas F Solbach et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Profiling of a Prescription Drug Library for Potential Renal Drug–Drug Interactions Mediated by the Organic Cation Transporter 2
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- Interindividual Differences in Placental Expression of the SLC22A2 (OCT2) Gene: Relationship to Epigenetic variations in the 5′-Upstream Regulatory Region
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- Characterization of Human OCT1-Mediated Transport of DAPI as a Fluorescent Probe Substrate
- (2011) Tomoya Yasujima et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons
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- Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins
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- Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of Paraquat and Deteriorates Kidney Injury in Mice
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- Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response
- (2011) A Bacq et al. MOLECULAR PSYCHIATRY
- Human metabolic individuality in biomedical and pharmaceutical research
- (2011) Karsten Suhre et al. NATURE
- Oxybutynin and trospium are substrates of the human organic cation transporters
- (2011) Birger Wenge et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c
- (2011) Mette M.H. Christensen et al. Pharmacogenetics and Genomics
- Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
- (2011) Anne T. Nies et al. PLoS One
- DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
- (2011) Elke Schaeffeler et al. Genome Medicine
- Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue
- (2011) Federico Innocenti et al. PLoS Genetics
- Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions
- (2010) Giuliano Ciarimboli et al. AMERICAN JOURNAL OF PATHOLOGY
- Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines
- (2010) Maricla Galetti et al. BIOCHEMICAL PHARMACOLOGY
- Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity
- (2010) Takanori Nakamura et al. BIOCHEMICAL PHARMACOLOGY
- Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)
- (2010) H Burger et al. BRITISH JOURNAL OF PHARMACOLOGY
- Prediction of Fluoroquinolone-Induced Elevation in Serum Creatinine Levels: A Case of Drug–Endogenous Substance Interaction Involving the Inhibition of Renal Secretion
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- OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects
- (2010) J. M. Moreno-Navarrete et al. DIABETES
- Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
- (2010) T. Sugiura et al. DRUG METABOLISM AND DISPOSITION
- Evaluation of 4',6-Diamidino-2-phenylindole as a Fluorescent Probe Substrate for Rapid Assays of the Functionality of Human Multidrug and Toxin Extrusion Proteins
- (2010) T. Yasujima et al. DRUG METABOLISM AND DISPOSITION
- Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2
- (2010) Simon Newstead et al. EMBO JOURNAL
- ColonOCTN2Gene Expression Is Up-regulated by Peroxisome Proliferator-activated Receptor γ in Humans and Mice and Contributes to Local and Systemic Carnitine Homeostasis
- (2010) Giuseppe D'Argenio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adherence Is the Critical Factor for Achieving Molecular Responses in Patients With Chronic Myeloid Leukemia Who Achieve Complete Cytogenetic Responses on Imatinib
- (2010) David Marin et al. JOURNAL OF CLINICAL ONCOLOGY
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- (2010) Takeshi Sakata et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Genetic Polymorphisms in Organic Cation Transporter 1 (OCT1) in Chinese and Japanese Populations Exhibit Altered Function
- (2010) L. Chen et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Selective Transport of Monoamine Neurotransmitters by Human Plasma Membrane Monoamine Transporter and Organic Cation Transporter 3
- (2010) H. Duan et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue
- (2010) Swati S. More et al. MOLECULAR CANCER THERAPEUTICS
- New Clues for Nephrotoxicity Induced by Ifosfamide: Preferential Renal Uptake via the Human Organic Cation Transporter 2
- (2010) Giuliano Ciarimboli et al. MOLECULAR PHARMACEUTICS
- Prevention by l-carnitine of DNA damage induced by propionic and l-methylmalonic acids in human peripheral leukocytes in vitro
- (2010) Graziela S. Ribas et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Structure of a cation-bound multidrug and toxic compound extrusion transporter
- (2010) Xiao He et al. NATURE
- Structure of a fucose transporter in an outward-open conformation
- (2010) Shangyu Dang et al. NATURE
- New loci associated with kidney function and chronic kidney disease
- (2010) Anna Köttgen et al. NATURE GENETICS
- I-TASSER: a unified platform for automated protein structure and function prediction
- (2010) Ambrish Roy et al. Nature Protocols
- Membrane transporters in drug development
- (2010) NATURE REVIEWS DRUG DISCOVERY
- Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1
- (2010) Yukio Kato et al. PHARMACEUTICAL RESEARCH
- OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
- (2010) Zhi-Jun Wang et al. Pharmacogenetics and Genomics
- Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients
- (2010) Kana Toyama et al. Pharmacogenetics and Genomics
- Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
- (2010) Ligong Chen et al. Pharmacogenetics and Genomics
- Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions
- (2010) G Ahlin et al. PHARMACOGENOMICS JOURNAL
- Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron
- (2010) M V Tzvetkov et al. PHARMACOGENOMICS JOURNAL
- Isoforms, Expression, Glycosylation, and Tissue Distribution of CTL2/SLC44A2
- (2010) P. K. Kommareddi et al. PROTEIN JOURNAL
- Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2
- (2009) Yuko Tanihara et al. BIOCHEMICAL PHARMACOLOGY
- Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
- (2009) Naoko Kimura et al. BIOCHEMICAL PHARMACOLOGY
- Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: Gain-of-function by interchange of selected amino acids
- (2009) Petra Bacher et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
- (2009) K K Filipski et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
- (2009) M V Tzvetkov et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study
- (2009) K. Zhou et al. DIABETES
- Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study
- (2009) M. L. Becker et al. DIABETES
- Interaction of beta-blockers with the renal uptake transporter OCT2
- (2009) I. Bachmakov et al. DIABETES OBESITY & METABOLISM
- Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser
- (2009) O. Zolk et al. DRUG METABOLISM AND DISPOSITION
- Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2
- (2009) Y. Cheng et al. DRUG METABOLISM AND DISPOSITION
- Differential Regulation of Drug Transporter Expression by Hepatocyte Growth Factor in Primary Human Hepatocytes
- (2009) M. Le Vee et al. DRUG METABOLISM AND DISPOSITION
- Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant
- (2009) T. Minematsu et al. DRUG METABOLISM AND DISPOSITION
- Genetic Variations of the SLC22A4 Gene in Chinese and Indian Populations of Singapore
- (2009) Dorothy Su Lin Toh et al. Drug Metabolism and Pharmacokinetics
- Dopamine Transporter Genetic Variants and Pesticides in Parkinson’s Disease
- (2009) Beate R. Ritz et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Skin cells and tissue are capable of using l-ergothioneine as an integral component of their antioxidant defense system
- (2009) Nelli G. Markova et al. FREE RADICAL BIOLOGY AND MEDICINE
- Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
- (2009) Anne T. Nies et al. HEPATOLOGY
- The Organic Cation Transporter, OCTN1, Expressed in the Human Heart, Potentiates Antagonism of the HERG Potassium Channel
- (2009) Brian F McBride et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity
- (2009) Moto Kajiwara et al. JOURNAL OF HUMAN GENETICS
- Decreased anxiety in mice lacking the organic cation transporter 3
- (2009) Thomas Wultsch et al. JOURNAL OF NEURAL TRANSMISSION
- Functional Genetic Variation in the Basal Promoter of the Organic Cation/Carnitine Transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5)
- (2009) H. Tahara et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
- (2009) M. Tsuda et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Transport of Lamivudine [(-)- -L-2',3'-Dideoxy-3'-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3
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- Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption
- (2009) Toshimichi Nakamura et al. MOLECULAR PHARMACEUTICS
- Five Amino Acids in the Innermost Cavity of the Substrate Binding Cleft of Organic Cation Transporter 1 Interact with Extracellular and Intracellular Corticosterone
- (2009) C. Volk et al. MOLECULAR PHARMACOLOGY
- Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin
- (2009) M. Tsuda et al. MOLECULAR PHARMACOLOGY
- Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
- (2009) David-Alexandre Trégouët et al. NATURE GENETICS
- Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1
- (2009) Ji Ha Choi et al. Pharmacogenetics and Genomics
- Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
- (2009) Ying Chen et al. Pharmacogenetics and Genomics
- Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response
- (2009) Matthijs L. Becker et al. Pharmacogenetics and Genomics
- Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function
- (2009) Ying Chen et al. PHARMACOGENOMICS JOURNAL
- Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus
- (2009) M L Becker et al. PHARMACOGENOMICS JOURNAL
- Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches
- (2009) Richard Kvetnansky et al. PHYSIOLOGICAL REVIEWS
- The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
- (2009) M. Cui et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1)
- (2008) Moto Kajiwara et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
- (2008) D. Marin et al. BLOOD
- Interaction of Cisplatin with the Human Organic Cation Transporter 2
- (2008) K. K. Filipski et al. CLINICAL CANCER RESEARCH
- Interaction of Imatinib with Human Organic Ion Carriers
- (2008) S. Hu et al. CLINICAL CANCER RESEARCH
- Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
- (2008) IS Song et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Interaction of Oral Antidiabetic Drugs With Hepatic Uptake Transporters: Focus on Organic Anion Transporting Polypeptides and Organic Cation Transporter 1
- (2008) I. Bachmakov et al. DIABETES
- Metformin and the intestine
- (2008) C. J. Bailey et al. DIABETOLOGIA
- Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition
- (2008) T. Zhang et al. DRUG METABOLISM AND DISPOSITION
- The Carnitine Transporter SLC22A5 Is Not a General Drug Transporter, but It Efficiently Translocates Mildronate
- (2008) S. Grigat et al. DRUG METABOLISM AND DISPOSITION
- The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
- (2008) S. Matsushima et al. DRUG METABOLISM AND DISPOSITION
- Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer
- (2008) S. Yokoo et al. DRUG METABOLISM AND DISPOSITION
- Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
- (2008) X. Ming et al. DRUG METABOLISM AND DISPOSITION
- Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection
- (2008) N. Jung et al. DRUG METABOLISM AND DISPOSITION
- Role of Na+/L-carnitine Transporter (OCTN2) in Renal Handling of Pivaloylcarnitine and Valproylcarnitine Formed during Pivalic Acid-containing Prodrugs and Valproic Acid Treatment
- (2008) Shuichi Ohnishi et al. Drug Metabolism and Pharmacokinetics
- Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain
- (2008) Paul J. Gasser et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
- (2008) Qingshan Chang et al. JOURNAL OF HEPATOLOGY
- Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1
- (2008) Gustav Ahlin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice
- (2008) Vincent Vialou et al. JOURNAL OF NEUROCHEMISTRY
- Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
- (2008) Kittipong Tachampa et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
- (2008) N. Pabla et al. KIDNEY INTERNATIONAL
- Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
- (2008) M. Okabe et al. MOLECULAR CANCER THERAPEUTICS
- Cardiomyopathy and carnitine deficiency
- (2008) Cristina Amat di San Filippo et al. MOLECULAR GENETICS AND METABOLISM
- The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs
- (2008) C. A. Larson et al. MOLECULAR PHARMACOLOGY
- Multiple newly identified loci associated with prostate cancer susceptibility
- (2008) Rosalind A Eeles et al. NATURE GENETICS
- Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2)
- (2008) Oliver Zolk et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
- (2008) Katherine S. Lovejoy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice
- (2008) N. L. Baganz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of GSK3 in behavioral abnormalities induced by serotonin deficiency
- (2008) J.-M. Beaulieu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1–3in vitroand implications for drug–drug interactions
- (2008) K.-I. Umehara et al. XENOBIOTICA
- Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics
- (2008) Y. Moriyama et al. XENOBIOTICA
- Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes
- (2008) I. S. Song et al. XENOBIOTICA
- Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment
- (2007) R. J. Dinis-Oliveira et al. CRITICAL REVIEWS IN TOXICOLOGY
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