Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity
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Title
Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity
Authors
Keywords
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Journal
Frontiers in Endocrinology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-11-25
DOI
10.3389/fendo.2015.00174
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Note: Only part of the references are listed.- Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study
- (2015) Jennifer Q. Dong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
- (2015) Murielle M. Véniant et al. Cell Metabolism
- Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
- (2015) Aaron M. Cypess et al. Cell Metabolism
- Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress
- (2015) Labros S. Sidossis et al. Cell Metabolism
- Human Brown Adipose Tissue: What We Have Learned So Far
- (2015) Matthias J. Betz et al. DIABETES
- Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
- (2015) Patrick Seale DIABETES
- Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes
- (2015) Denis P. Blondin et al. DIABETES
- FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis
- (2015) R. Zechner EMBO Molecular Medicine
- In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis
- (2015) Sébastien M. Labbé et al. FASEB JOURNAL
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- (2015) Brice Emanuelli et al. JOURNAL OF CLINICAL INVESTIGATION
- Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
- (2015) Santiago Garcia-Vallvé et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thermogenic Activity of UCP1 in Human White Fat-Derived Beige Adipocytes
- (2015) Stefano Bartesaghi et al. MOLECULAR ENDOCRINOLOGY
- Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
- (2015) Mark J W Hanssen et al. NATURE MEDICINE
- Formation and activation of thermogenic fat
- (2015) Jun Wu et al. TRENDS IN GENETICS
- Serum FGF21 levels are associated with brown adipose tissue activity in humans
- (2015) Mark J.W. Hanssen et al. Scientific Reports
- Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
- (2015) Ricardo J. Samms et al. Cell Reports
- Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
- (2015) Susanne Keipert et al. Molecular Metabolism
- Integration of body temperature into the analysis of energy expenditure in the mouse
- (2015) Gustavo Abreu-Vieira et al. Molecular Metabolism
- Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
- (2015) Ganesh Kolumam et al. EBioMedicine
- Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human
- (2015) Qidi Wang et al. PLoS One
- FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
- (2014) Bryn M. Owen et al. Cell Metabolism
- The Browning of White Adipose Tissue: Some Burning Issues
- (2014) Jan Nedergaard et al. Cell Metabolism
- Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes
- (2014) Raymond E. Soccio et al. Cell Metabolism
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- (2014) Paul Lee et al. Cell Metabolism
- Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
- (2014) Paul Lee et al. DIABETES
- Evaluation of the relationship between weight change and glycemic control after initiation of antidiabetic therapy in patients with type 2 diabetes using electronic medical record data
- (2014) Carrie McAdam-Marx et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
- (2014) Y. Li et al. EMBO REPORTS
- PPARγ ligands and their therapeutic applications: a patent review (2008 – 2014)
- (2014) Ichiro Takada et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
- (2014) Denis P. Blondin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
- (2014) Aurora Merovci et al. JOURNAL OF CLINICAL INVESTIGATION
- FGF21 is an endocrine signal of protein restriction
- (2014) Thomas Laeger et al. JOURNAL OF CLINICAL INVESTIGATION
- Modeling energy intake by adding homeostatic feedback and drug intervention
- (2014) Peter Gennemark et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men
- (2014) Denis P. Blondin et al. JOURNAL OF PHYSIOLOGY-LONDON
- An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
- (2014) Alexander S. Banks et al. NATURE
- White-to-brown metabolic conversion of human adipocytes by JAK inhibition
- (2014) Annie Moisan et al. NATURE CELL BIOLOGY
- FGF21-based pharmacotherapy – potential utility for metabolic disorders
- (2014) Ruth E. Gimeno et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis
- (2013) Shingo Kajimura et al. Annual Review of Physiology
- White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
- (2013) Andrea Frontini et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans
- (2013) Naja Zenius Jespersen et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
- (2013) João Paulo G. Camporez et al. ENDOCRINOLOGY
- An evolving understanding of nuclear receptor coregulator proteins
- (2013) Christopher J Millard et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
- (2013) Elayne Hondares et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Energy dissipation in brown adipose tissue: From mice to men
- (2013) Maarten J. Vosselman et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Bi-directional interconversion of brite and white adipocytes
- (2013) Matthias Rosenwald et al. NATURE CELL BIOLOGY
- Brown and beige fat: development, function and therapeutic potential
- (2013) Matthew Harms et al. NATURE MEDICINE
- Evidence for two types of brown adipose tissue in humans
- (2013) Martin E Lidell et al. NATURE MEDICINE
- PPARγ signaling and metabolism: the good, the bad and the future
- (2013) Maryam Ahmadian et al. NATURE MEDICINE
- Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
- (2013) Aaron M Cypess et al. NATURE MEDICINE
- Adipose tissue browning and metabolic health
- (2013) Alexander Bartelt et al. Nature Reviews Endocrinology
- Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected Brown Adipose Tissue in Humans Living in a Temperate Zone of Italy
- (2013) Agnese Persichetti et al. PLoS One
- Understanding the brown adipocyte as a contributor to energy homeostasis
- (2013) Kanta Chechi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic
- (2013) Irina G. Shabalina et al. Cell Reports
- Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue
- (2012) Nicole H. Rogers et al. AGING CELL
- PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
- (2012) William T. Festuccia et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- (2012) Jun Wu et al. CELL
- PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
- (2012) Haruya Ohno et al. Cell Metabolism
- Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal
- (2012) Bo Angelin et al. Cell Metabolism
- βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
- (2012) Xunshan Ding et al. Cell Metabolism
- Systemic -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans
- (2012) M. J. Vosselman et al. DIABETES
- Ephedrine activates brown adipose tissue in lean but not obese humans
- (2012) A. L. Carey et al. DIABETOLOGIA
- Examining the safety of PPAR agonists – current trends and future prospects
- (2012) Michele Bortolini et al. Expert Opinion On Drug Safety
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply
- (2012) Emilio P. Mottillo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects
- (2012) G. H. E. J. Vijgen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
- (2012) Véronique Ouellet et al. JOURNAL OF CLINICAL INVESTIGATION
- FGF21 Requires βklotho to Act In Vivo
- (2012) Andrew C. Adams et al. PLoS One
- Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
- (2012) Louis Z. Sharp et al. PLoS One
- Cold but not sympathomimetics activates human brown adipose tissue in vivo
- (2012) A. M. Cypess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Implications of nonshivering thermogenesis for energy balance regulation in humans
- (2011) Wouter D. van Marken Lichtenbelt et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
- (2011) Maryam Ahmadian et al. Cell Metabolism
- Rational Targeting of Peroxisome Proliferating Activated Receptor Subtypes
- (2011) D. K. Nevin et al. CURRENT MEDICINAL CHEMISTRY
- Inducible Brown Adipogenesis of Supraclavicular Fat in Adult Humans
- (2011) Paul Lee et al. ENDOCRINOLOGY
- Quantification of the effect of energy imbalance on bodyweight
- (2011) Kevin D Hall et al. LANCET
- Unknown
- (2011) Dionysios Chartoumpekis et al. MOLECULAR MEDICINE
- Brown adipose tissue activity controls triglyceride clearance
- (2011) Alexander Bartelt et al. NATURE MEDICINE
- Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ
- (2011) William T. Festuccia et al. Frontiers in Endocrinology
- A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
- (2010) Paul Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Nuclear Receptor Coactivators: Structural and Functional Biochemistry
- (2010) Yaroslava A. Bulynko et al. BIOCHEMISTRY
- Human Brown Adipose Tissue
- (2010) Sven Enerbäck Cell Metabolism
- Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
- (2010) Patrick Seale et al. JOURNAL OF CLINICAL INVESTIGATION
- The PPARγ agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake
- (2009) William T. Festuccia et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity
- (2009) M. Saito et al. DIABETES
- Functional Brown Adipose Tissue in Healthy Adults
- (2009) Kirsi A. Virtanen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cold-Activated Brown Adipose Tissue in Healthy Men
- (2009) Wouter D. van Marken Lichtenbelt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification and Importance of Brown Adipose Tissue in Adult Humans
- (2009) Aaron M. Cypess et al. NEW ENGLAND JOURNAL OF MEDICINE
- De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis
- (2009) Mohamed Sabry Hamza et al. PLoS One
- Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
- (2009) D. D. Sears et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thermogenesis challenges the adipostat hypothesis for body-weight control
- (2009) Barbara Cannon et al. PROCEEDINGS OF THE NUTRITION SOCIETY
- Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
- (2009) Christian Elabd et al. STEM CELLS
- Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist
- (2008) Natasa Petrovic et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Peroxisome Proliferator-Activated Receptor γ Agonists as Insulin Sensitizers: From the Discovery to Recent Progress
- (2008) Nobuo Cho et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status
- (2008) William T. Festuccia et al. ENDOCRINOLOGY
- PRDM16 controls a brown fat/skeletal muscle switch
- (2008) Patrick Seale et al. NATURE
- The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists
- (2008) Jonathan R. S. Arch NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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