Review
Pharmacology & Pharmacy
Andrzej Czyrski, Matylda Resztak, Pawel Swiderski, Jan Brylak, Franciszek K. Glowka
Summary: Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, characterized by a broad range of activity, but individual drugs vary considerably in safety, tolerability, pharmacokinetics profiles, and interactions with concomitant medications. Caution should be exercised when using these drugs, with an understanding of their pharmacokinetics, safety, and drug-drug interactions to ensure effective antifungal therapy. The manuscript reviews significant drug interactions of azoles with other medications, as well as with food, and highlights possible interactions during experimental therapies for the treatment of COVID-19.
Article
Pathology
Rida A. Hasan, Jennifer Pak, Christa Jefferis Kirk, Joshua M. Friedland-Little, Wayne L. Chandler
Summary: The plasma diluted thrombin time (dTT) showed a more stable dose-response relationship and stronger correlation with DTI dose compared to activated partial thromboplastin time (aPTT) in pediatric patients receiving argatroban and bivalirudin. The variation in dose-response curves was higher for argatroban compared to bivalirudin.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Florian Klammers, Andreas Goetschi, Aynur Ekiciler, Isabelle Walter, Neil Parrott, Stephen Fowler, Kenichi Umehara
Summary: The estimation of drug metabolism by specific hepatic enzymes has been challenging, but this study proposes a new method using chemical inhibitors and a hepatocyte coculture system to accurately estimate the fraction metabolized. This approach can assist in assessing drug-drug interactions and supporting the development of low clearance drug candidates.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Gastroenterology & Hepatology
Nachiket Vartak, Dirk Drasdo, Fabian Geisler, Tohru Itoh, Ronald P.J.Oude Elferink, Stan F. J. van de Graaf, John Chiang, Verena Keitel, Michael Trauner, Peter Jansen, Jan G. Hengstler
Summary: Research suggests that the transport of small molecules in bile canaliculi is primarily diffusion dominated, with negligible canalicular flow. In the interlobular ducts, diffusion is enhanced by flow. Bile canaliculi can be likened to a standing water zone connected to a river, and understanding the subtle difference between diffusion and flow is crucial for the treatment of various liver diseases.
Review
Pharmacology & Pharmacy
Shiwei Zhou, Sujuan Zeng, Yan Shu
Summary: This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rivkah Rogawski, Adi Rogel, Itai Bloch, Maayan Gal, Amnon Horovitz, Nir London, Michal Sharon
Summary: Researchers have developed a method based on native mass spectrometry for analyzing drug uptake and target engagement in cellular contexts. This approach utilizes direct MS for label-free studies of protein-drug binding in human cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Oncology
Alice Boileve, Marc Hilmi, Cristina Smolenschi, Michel Ducreux, Antoine Hollebecque, David Malka
Summary: In the past decade, immune therapies have ushered in a new era in oncology, but their clinical activity in biliary tract cancers, particularly immune checkpoint inhibitors, is limited and largely investigational. Patients with microsatellite-instable tumors have shown some positive responses, but the majority of biliary tract cancer patients still face poor prognoses. Predictive biomarkers are being explored to improve patient selection for immunotherapy, including exploring combinations with other treatment modalities to enhance efficacy.
Article
Microbiology
Irene Hernandez-Lozano, Severin Mairinger, Thomas Filip, Mathilde Loebsch, Johann Stanek, Claudia Kuntner, Martin Bauer, Markus Zeitlinger, Marcus Hacker, Thomas H. Helbich, Thomas Wanek, Oliver Langer
Summary: Transporter-mediated drug-drug interactions (DDIs) can have serious safety consequences in antimicrobial drug development. This study used PET imaging-based PK analysis to evaluate the effect of different drugs on the tissue distribution and excretion of [F-18]ciprofloxacin as a model drug. Results showed that pretreatment with probenecid and cimetidine significantly decreased the renal clearance of [F-18]ciprofloxacin. The study highlights the importance of PET imaging-based PK analysis in assessing transporter-mediated DDIs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
D. Paul Mallory, Abegel Freedman, Megan J. Kaliszewski, Gladys Rocio Montenegro-Galindo, Coleen Pugh, Adam W. Smith
Summary: A range of nanocarrier technologies have advantages in drug delivery systems, but the characterization of their properties in physiological conditions is crucial for optimization. PEGylation is a commonly used method to reduce premature elimination of nanocarriers by avoiding protein adsorption, but recent studies suggest delayed immune responses due to protein-nanocarrier interactions. This study uses PIE-FCCS to investigate the interactions between PEG-based micelles and serum albumin, revealing the potential utility of PIE-FCCS in characterizing drug delivery systems in biomimetic conditions.
Article
Gastroenterology & Hepatology
Fang Jiang, Chengsheng Ju, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wallis C. Y. Lau, Wai K. Leung
Summary: This study investigated the risk of hospitalization for upper gastrointestinal bleeding (UGIB) in patients who had received H. pylori eradication therapy and were newly started on warfarin or DOACs. The results showed that DOACs had a significantly lower risk of UGIB compared to warfarin in H. pylori-eradicated patients. Additionally, there was no significant difference in UGIB risk between H. pylori-eradicated and H. pylori-negative patients newly started on warfarin or DOACs.
Review
Pharmacology & Pharmacy
Nicola Ferri, Elisa Colombo, Marco Tenconi, Ludovico Baldessin, Alberto Corsini
Summary: Direct oral anticoagulants (DOACs) are frequently prescribed to prevent ischemic stroke in non-valvular atrial fibrillation (NVAF) patients and treat venous thromboembolism (VTE). They have a favorable risk-benefit profile compared to warfarin but may increase the risk of gastrointestinal bleeding. Polypharmacy and comorbidity in elderly patients can lead to drug-drug interactions (DDIs) with DOACs. This review summarizes potential DDIs and discusses strategies to reduce their occurrence.
Article
Biochemistry & Molecular Biology
Johannes Morstein, Rebika Shrestha, Que N. Van, Cesar A. Lopez, Neha Arora, Marco Tonelli, Hong Liang, De Chen, Yong Zhou, John F. Hancock, Andrew G. Stephen, Thomas J. Turbyville, Kevan M. Shokat
Summary: Protein-membrane interactions (PMIs) play a crucial role in cellular signaling. By conjugating a medium-chain lipid tail to the covalent K-Ras(G12C) binder MRTX849, PMIs can be directly modulated. This strategy allows for selective modulation of transient PMIs.
ACS CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alain Ibanez de Opakua, James A. Geraets, Benedikt Frieg, Christian Dienemann, Adriana Savastano, Marija Rankovic, Maria-Sol Cima-Omori, Gunnar F. Schroeder, Markus Zweckstetter
Summary: Through the use of NMR spectroscopy and cryoelectron microscopy, researchers have identified specific beta-structures and alpha-helix within the FG repeat domain of Nup98, as well as revealed the molecular organization of FG-FG interactions. Additionally, they demonstrated that amyloid-like aggregates formed by the FG repeat domain of Nup98 have low stability and are reversible.
Article
Gastroenterology & Hepatology
Vicki Wing-Ki Hui, Christopher Langjun Au, Amy Shuk Man Lam, Terry Cheuk-Fung Yip, Yee-Kit Tse, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
Summary: This study aimed to examine the drug-drug interactions (DDIs) between direct-acting antiviral (DAA) regimens and other co-medications in patients with chronic hepatitis C virus (HCV). The study found that statins and antipsychotics were the most common contraindicated co-medications during DAA treatment. Appropriate dose adjustments or temporary discontinuation of relevant co-medications were common strategies to manage these interactions.
HEPATOLOGY INTERNATIONAL
(2022)
Review
Chemistry, Multidisciplinary
Yi Huang, Jonathan Wang, Kairui Jiang, Eun Ji Chung
Summary: Kidney-targeted nanoparticles offer a promising approach for drug delivery to diseased tissues with reduced side effects, and understanding the impact of nanoparticle properties such as size, charge, shape, and material density on kidney interaction is crucial for designing effective drug delivery systems for chronic kidney disease. Active targeting strategies can enhance nanoparticle retention in the kidney, showing potential for improving treatment outcomes in kidney diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)