Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates
Authors
Keywords
-
Journal
PLoS One
Volume 10, Issue 9, Pages e0136451
Publisher
Public Library of Science (PLoS)
Online
2015-09-02
DOI
10.1371/journal.pone.0136451
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action
- (2014) Kai Wang et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters
- (2013) Barbara Grün et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effect of Concomitant Administration of Trospium Chloride Extended Release on the Steady-State Pharmacokinetics of Metformin in Healthy Adults
- (2013) Michael G. Oefelein et al. CLINICAL DRUG INVESTIGATION
- The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects
- (2013) Yi Ding et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Combinatorial Pharmacophore Modeling of Organic Cation Transporter 2 (OCT2) Inhibitors: Insights into Multiple Inhibitory Mechanisms
- (2013) Yuan Xu et al. MOLECULAR PHARMACEUTICS
- Substrate- and Cell Contact-Dependent Inhibitor Affinity of Human Organic Cation Transporter 2: Studies with Two Classical Organic Cation Substrates and the Novel Substrate Cd2+
- (2013) Frank Thévenod et al. MOLECULAR PHARMACEUTICS
- Computational Modeling to Accelerate the Identification of Substrates and Inhibitors for Transporters That Affect Drug Disposition
- (2012) S Ekins et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects
- (2011) H Kusuhara et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Profiling of a Prescription Drug Library for Potential Renal Drug–Drug Interactions Mediated by the Organic Cation Transporter 2
- (2011) Yasuto Kido et al. JOURNAL OF MEDICINAL CHEMISTRY
- Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
- (2011) Anne T. Nies et al. PLoS One
- Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters
- (2011) Britta Haenisch et al. PSYCHOPHARMACOLOGY
- Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
- (2010) S. Ito et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Membrane transporters in drug development
- (2010) NATURE REVIEWS DRUG DISCOVERY
- Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters
- (2010) Min-Koo Choi et al. XENOBIOTICA
- Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser
- (2009) O. Zolk et al. DRUG METABOLISM AND DISPOSITION
- Physicochemical Determinants of Human Renal Clearance
- (2009) Manthena V. S. Varma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
- (2009) M. Tsuda et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2)
- (2008) Oliver Zolk et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More