A phosphotyrosine switch regulates organic cation transporters

Clinical Course of Oxaliplatin-Induced Neuropathy: Results From the Randomized Phase III Trial N08CB (Alliance)

(2015) Deirdre R. Pachman et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

(2015) Navjotsingh Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2

(2014) Su Sien Ong et al.   BIOCHEMICAL JOURNAL

Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro–in vivo correlations

(2014) S Hu et al.   BRITISH JOURNAL OF CANCER

Comparative Functional Analysis of DPYD Variants of Potential Clinical Relevance to Dihydropyrimidine Dehydrogenase Activity

(2014) S. M. Offer et al.   CANCER RESEARCH

A Secreted Tyrosine Kinase Acts in the Extracellular Environment

(2014) Mattia R. Bordoli et al.   CELL

Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53

(2014) J. A. Sprowl et al.   CLINICAL CANCER RESEARCH

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors

(2014) Jiexin Deng et al.   PHARMACEUTICAL RESEARCH

The Genesis of Tyrosine Phosphorylation

(2014) T. Hunter   Cold Spring Harbor Perspectives in Biology

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Optimized atomic statistical potentials: assessment of protein interfaces and loops

(2013) Guang Qiang Dong et al.   BIOINFORMATICS

Identification of potent Yes1 kinase inhibitors using a library screening approach

(2013) Paresma R. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

(2013) B. D. Furmanski et al.   CLINICAL CANCER RESEARCH

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Crystal structure of a eukaryotic phosphate transporter

(2013) Bjørn P. Pedersen et al.   NATURE

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2

(2013) J. A. Sprowl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance

(2012) Alexander Levitzki   Annual Review of Pharmacology and Toxicology

Regulation of Organic Cation Transport in Isolated Mouse Proximal Tubules Involves Complex Changes in Protein Trafficking and Substrate Affinity

(2012) Denise Guckel et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

(2012) G. Ciarimboli et al.   CLINICAL CANCER RESEARCH

Pharmacogenomics and Patient Care: One Size Does Not Fit All

(2012) K. M. Giacomini et al.   Science Translational Medicine

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Signaling from the Living Plasma Membrane

(2011) Hernán E. Grecco et al.   CELL

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

(2011) T. Minematsu et al.   MOLECULAR CANCER THERAPEUTICS

Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response

(2011) A Bacq et al.   MOLECULAR PSYCHIATRY

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

(2010) Jiannong Li et al.   Nature Chemical Biology

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Pharmacoepigenetics: Its Role in Interindividual Differences in Drug Response

(2009) A Gomez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

(2009) I. Sato et al.   JOURNAL OF CELL SCIENCE

Proinflammatory-Activated Trigeminal Satellite Cells Promote Neuronal Sensitization: Relevance for Migraine Pathology

(2009) Alessandro Capuano et al.   Molecular Pain

Structure and dynamic regulation of Src-family kinases

(2008) J. R. Engen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interaction of Cisplatin with the Human Organic Cation Transporter 2

(2008) K. K. Filipski et al.   CLINICAL CANCER RESEARCH

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH