Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

(2019) Sonia Olivia Spitzer et al.   NEURON

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

(2019) Martin Hsu et al.   Nature Communications

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease

(2019) Nicholas J. Ashton et al.   Science Advances

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

(2019) Jean C. Cruz Hernández et al.   NATURE NEUROSCIENCE

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

(2019) Xiaoyu Liu et al.   IMMUNITY

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Exercise and Hippocampal Memory Systems

(2019) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

(2019) Kathlyn J. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders

(2018) G. B. Stefano et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics

(2018) Andrew C. Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Leukaemia hijacks a neural mechanism to invade the central nervous system

(2018) Hisayuki Yao et al.   NATURE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2

(2018) Lihui Duan et al.   NEURON

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

(2018) Min Hee Park et al.   NEURON

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures

(2018) Jagannath Swaminathan et al.   NATURE BIOTECHNOLOGY

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

(2018) Jae Kyu Ryu et al.   NATURE IMMUNOLOGY

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

The Meningeal Lymphatic System: A New Player in Neurophysiology

(2018) Sandro Da Mesquita et al.   NEURON

Klotho controls the brain–immune system interface in the choroid plexus

(2018) Lei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study

(2018) Sharon J. Sha et al.   JAMA Neurology

Gpr158 mediates osteocalcin’s regulation of cognition

(2017) Lori Khrimian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia-dependent synapse loss in type I interferon-mediated lupus

(2017) Allison R. Bialas et al.   NATURE

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

(2017) Sandra Zárate et al.   Frontiers in Aging Neuroscience

GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice

(2017) Tim D. Boyd et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

(2017) Myles R. Minter et al.   Scientific Reports

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

(2016) Violeta Silva-Vargas et al.   Cell Stem Cell

Gene Therapy Strategies for Alzheimer's Disease: An Overview

(2016) Sandro Alves et al.   HUMAN GENE THERAPY

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

(2016) Thomas Blank et al.   IMMUNITY

Engineered Aminoacyl-tRNA Synthetase for Cell-Selective Analysis of Mammalian Protein Synthesis

(2016) Alborz Mahdavi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Activation of the reward system boosts innate and adaptive immunity

(2016) Tamar L Ben-Shaanan et al.   NATURE MEDICINE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

(2016) Jinte Middeldorp et al.   JAMA Neurology

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

(2014) Martina Sattlecker et al.   Alzheimers & Dementia

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Circulating Proteomic Signatures of Chronological Age

(2014) Cristina Menni et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal

(2014) Thomas S Elliott et al.   NATURE BIOTECHNOLOGY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

The promise and perils of HDAC inhibitors in neurodegeneration

(2014) Alessandro Didonna et al.   Annals of Clinical and Translational Neurology

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells

(2013) J. T. Ngo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year

(2012) J. Winchester et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

(2010) Noel C. Derecki et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON