Co-regulatory networks of human serum proteins link genetics to disease

Global mapping of transcription factor motifs in human aging

(2018) David Alfego et al.   PLoS One

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Application of Quantitative Pharmacology Approaches in Bridging Pharmacokinetics and Pharmacodynamics of Domagrozumab From Adult Healthy Subjects to Pediatric Patients With Duchenne Muscular Disease

(2017) Indranil Bhattacharya et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays

(2017) Jochen M. Schwenk et al.   JOURNAL OF PROTEOME RESEARCH

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Gene co-expression network connectivity is an important determinant of selective constraint

(2017) Niklas Mähler et al.   PLoS Genetics

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

(2017) Le Shu et al.   PLoS Genetics

Assessment of Variability in the SOMAscan Assay

(2017) Julián Candia et al.   Scientific Reports

Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort: The ARIC study

(2016) Anandita Agarwala et al.   ATHEROSCLEROSIS

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

(2016) Ganesh Chauhan et al.   LANCET NEUROLOGY

Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank

(2016) María Muñoz et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer

(2015) Massimo Franchini et al.   BMC Medicine

Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction

(2015) Michelle M.Y. Chan et al.   EUROPEAN JOURNAL OF HEART FAILURE

Quantitative variability of 342 plasma proteins in a human twin population

(2015) Y. Liu et al.   Molecular Systems Biology

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

(2015) Yetrib Hathout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

(2015) Jialiang Yang et al.   Scientific Reports

Plasma NT-proBNP as predictor of change in functional status, cardiovascular morbidity and mortality in the oldest old: the Leiden 85-plus study

(2014) Petra G. van Peet et al.   AGE

PeptidePicker: A scientific workflow with web interface for selecting appropriate peptides for targeted proteomics experiments

(2014) Yassene Mohammed et al.   Journal of Proteomics

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs

(2014) Stefan Enroth et al.   Nature Communications

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel

(2013) Sungeun Kim et al.   PLoS One

Identification of genetic variants influencing the human plasma proteome

(2013) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data

(2012) Jason E Shoemaker et al.   BMC GENOMICS

Diagnosis and Classification of Diabetes Mellitus

(2012)   DIABETES CARE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

(2012) D. R. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted proteins as a fundamental source for biomarker discovery

(2012) Miroslava Stastna et al.   PROTEOMICS

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Genetic Variation Shapes Protein Networks Mainly through Non-transcriptional Mechanisms

(2011) Eric J. Foss et al.   PLOS BIOLOGY

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

Effect of Collision Energy Optimization on the Measurement of Peptides by Selected Reaction Monitoring (SRM) Mass Spectrometry

(2010) Brendan MacLean et al.   ANALYTICAL CHEMISTRY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Both WFIKKN1 and WFIKKN2 Have High Affinity for Growth and Differentiation Factors 8 and 11

(2008) Katalin Kondás et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE