Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

(2015) Susan L. Patterson   NEUROPHARMACOLOGY

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

(2014) Erica D. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis

(2014) Carolina A. Moraes et al.   MOLECULAR NEUROBIOLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Aging Differentially Affects the Loss of Neuronal Dendritic Spine, Neuroinflammation and Memory Impairment at Rats after Surgery

(2014) Yuan Le et al.   PLoS One

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

A role for sorting nexin 27 in AMPA receptor trafficking

(2014) Li Shen Loo et al.   Nature Communications

Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)

(2013) P. Gonzalez et al.   BRAIN BEHAVIOR AND IMMUNITY

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

(2013) Sandra Jurado et al.   NEURON

Exercise and Sodium Butyrate Transform a Subthreshold Learning Event into Long-Term Memory via a Brain-Derived Neurotrophic factor-Dependent Mechanism

(2013) Karlie A Intlekofer et al.   NEUROPSYCHOPHARMACOLOGY

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults

(2013) David Gosselin et al.   Frontiers in Cellular Neuroscience

Synaptopathies: diseases of the synaptome

(2012) Seth GN Grant   CURRENT OPINION IN NEUROBIOLOGY

Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

(2012) R. M. Barrientos et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1  via p38 Mitogen-Activated Protein Kinase

(2012) L. Tong et al.   JOURNAL OF NEUROSCIENCE

Structure of the activating IL-1 receptor signaling complex

(2012) Christoph Thomas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

(2012) X. Liu et al.   NEUROSCIENCE

Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

(2012) Teri L. Kissner et al.   PLoS One

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Brain-specific interleukin-1 receptor accessory protein in sleep regulation

(2011) Ping Taishi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation

(2011) Fabrizio Gardoni et al.   Journal of Neuroinflammation

Neuron-Specific Effects of Interleukin-1  Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLC 1, and ERK in Hippocampal Synaptoneurosomes

(2011) G. P. Cortese et al.   JOURNAL OF NEUROSCIENCE

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

(2011) Rong-Qing Chen et al.   NEUROPSYCHOPHARMACOLOGY

The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression

(2010) Andrew J. Tarr et al.   BEHAVIOURAL BRAIN RESEARCH

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

(2010) T. R. Chapman et al.   JOURNAL OF NEUROSCIENCE

Long-Term Potentiation-Dependent Spine Enlargement Requires Synaptic Ca2+-Permeable AMPA Receptors Recruited by CaM-Kinase I

(2010) D. A. Fortin et al.   JOURNAL OF NEUROSCIENCE

Differential dynamics and activity-dependent regulation of  - and  -neurexins at developing GABAergic synapses

(2010) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Inflammatory Cytokines IL-1β and TNF-α Regulate p75NTR Expression in CNS Neurons and Astrocytes by Distinct Cell-Type-Specific Signalling Mechanisms

(2009) Soyoung Choi et al.   ASN Neuro

IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344×BN F1 rats

(2009) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

(2009) Amy M. Hein et al.   BRAIN BEHAVIOR AND IMMUNITY

A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1

(2009) Dirk E. Smith et al.   IMMUNITY

Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain

(2009) Stefan Spulber et al.   JOURNAL OF NEUROIMMUNOLOGY

Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement

(2009) I. Goshen et al.   JOURNAL OF NEUROSCIENCE

Early detection of age-related memory deficits in individual mice

(2009) C. Fouquet et al.   NEUROBIOLOGY OF AGING

Long-Term Potentiation in Isolated Dendritic Spines

(2009) Amadou T. Corera et al.   PLoS One

Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

(2008) Jeffrey A. Fein et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic variation in the interleukin-1 -converting enzyme associates with cognitive function. The PROSPER study

(2008) S. Trompet et al.   BRAIN

A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687

(2008) Hsin-Lin Lu et al.   MOLECULAR IMMUNOLOGY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

(2007) Jing Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING