P-TEFb as A Promising Therapeutic Target

First targeted protein degrader hits the clinic

(2019) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

(2019) Apoorva Baluapuri et al.   MOLECULAR CELL

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

(2019) Andrii Bugai et al.   MOLECULAR CELL

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer

(2019) Jinglu Wang et al.   FASEB JOURNAL

Cyclin-dependent kinase-9 is a therapeutic target in MYC-expressing diffuse large B-cell lymphoma

(2019) Taylor Hashiguchi et al.   MOLECULAR CANCER THERAPEUTICS

A 50 year history of technologies that drove discovery in eukaryotic transcription regulation

(2019) John T. Lis   NATURE STRUCTURAL & MOLECULAR BIOLOGY

50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms

(2019) Robert G. Roeder   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

(2019) Ann Lin et al.   Science Translational Medicine

Eukaryotic Transcription Turns 50

(2019) Patrick Cramer   CELL

AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells.

(2019) Justin Cidado et al.   CLINICAL CANCER RESEARCH

Analog-sensitive cell line identifies cellular substrates of CDK9

(2019) Tim-Michael Decker et al.   Oncotarget

Targeting the Latent Reservoir for HIV-1

(2018) Srona Sengupta et al.   IMMUNITY

CDK9 inhibitors in acute myeloid leukemia

(2018) Silvia Boffo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183

(2018) Randy S. Schrecengost et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

(2018) Steven R. Whittaker et al.   Molecular Oncology

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies

(2018) Kaori Asamitsu et al.   MOLECULES

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

(2018) Jinlei Bian et al.   BIOORGANIC CHEMISTRY

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

(2018) Waleed Minzel et al.   CELL

Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma

(2018) Shiori Kinoshita et al.   HAEMATOLOGICA

CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia

(2018) Muhammed H. Rahaman et al.   INVESTIGATIONAL NEW DRUGS

A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II

(2018) Pabitra K. Parua et al.   NATURE

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

(2018) Huasong Lu et al.   NATURE

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

(2018) Kaiwei Liang et al.   CELL

BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication

(2018) Akhil Bowry et al.   Cell Reports

HEXIM1-Tat chimera inhibits HIV-1 replication

(2018) Marie Leoz et al.   PLoS Pathogens

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma

(2018) Hangzhan Ma et al.   EBioMedicine

CDK9: A key player in cancer and other diseases

(2017) Lia Carolina Franco et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE

(2017) Nikolas Ferreira dos Santos Paparidis et al.   Molecular BioSystems

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

(2017) Calla M Olson et al.   Nature Chemical Biology

Positive feedback loop mediated by protein phosphatase 1α mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer

(2017) Xiaming Liu et al.   NUCLEIC ACIDS RESEARCH

Targeted protein degradation by PROTACs

(2017) Taavi K. Neklesa et al.   PHARMACOLOGY & THERAPEUTICS

Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice

(2017) Sandra Medina-Moreno et al.   PLoS One

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

CDK9 is a prognostic marker and therapeutic target in pancreatic cancer

(2017) Anna-Laura Kretz et al.   TUMOR BIOLOGY

Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition

(2017) Joyoti Dey et al.   Scientific Reports

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

(2016) Tomohisa Tanaka et al.   ANTIVIRAL RESEARCH

P-TEFb goes viral

(2016) Justyna Zaborowska et al.   BIOESSAYS

Overview of CDK9 as a target in cancer research

(2016) Fatima Morales et al.   CELL CYCLE

Challenges and strategies for the eradication of the HIV reservoir

(2016) Jason T Kimata et al.   CURRENT OPINION IN IMMUNOLOGY

Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia

(2016) Peter H. Wiernik   EXPERT OPINION ON INVESTIGATIONAL DRUGS

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

(2016) Miriam Sansó et al.   GENES & DEVELOPMENT

Molecular mechanisms of HIV latency

(2016) Daniele C. Cary et al.   JOURNAL OF CLINICAL INVESTIGATION

The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence

(2016) Alexandra J. Murray et al.   JOURNAL OF IMMUNOLOGY

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

(2016) Yogesh A. Sonawane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

(2016) Tassa Saldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

Heptad-Specific Phosphorylation of RNA Polymerase II CTD

(2016) Roland Schüller et al.   MOLECULAR CELL

Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II

(2016) Xiaodong Lu et al.   NUCLEIC ACIDS RESEARCH

Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

(2016) Alexandre J. C. Quaresma et al.   NUCLEIC ACIDS RESEARCH

Persistent HIV-1 replication during antiretroviral therapy

(2016) Javier Martinez-Picado et al.   Current Opinion in HIV and AIDS

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

(2016) Annelie Hellvard et al.   Scientific Reports

Euphorbia Kansui Reactivates Latent HIV

(2016) Daniele C. Cary et al.   PLoS One

Short Communication: SAHA (Vorinostat) Induces CDK9 Thr-186 (T-Loop) Phosphorylation in Resting CD4+ T Cells: Implications for Reactivation of Latent HIV

(2015) Rajesh Ramakrishnan et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039

(2015) Mika Okamoto et al.   ANTIVIRAL RESEARCH

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

(2015) A. Baker et al.   CANCER RESEARCH

Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells

(2015) Juliane Arter et al.   JOURNAL OF NEUROCHEMISTRY

Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia

(2015) Joshua F. Zeidner et al.   LEUKEMIA RESEARCH

PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation

(2015) Swapna Aravind Gudipaty et al.   MOLECULAR AND CELLULAR BIOLOGY

HIV reservoirs: what, where and how to target them

(2015) Melissa J. Churchill et al.   NATURE REVIEWS MICROBIOLOGY

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression

(2015) Uri R. Mbonye et al.   PROTEOMICS

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation

(2015) Yeming Han et al.   Oncotarget

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

(2015) Huasong Lu et al.   eLife

Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein (snRNP) Activates Hexamethylene Bisacetamide-inducible Protein (HEXIM1) Transcription

(2014) Pingyang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of Positive Transcription Elongation Factor b (P-TEFb) Activation in Living Cells

(2014) Koh Fujinaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

(2014) Makoto Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors

(2014) C. Sekine et al.   JOURNAL OF IMMUNOLOGY

Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia

(2014) M-P Garcia-Cuellar et al.   LEUKEMIA

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

(2014) J. K. Jadlowsky et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel CDK9 Inhibitor Shows Potent Antitumor Efficacy in Preclinical Hematologic Tumor Models

(2014) T. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Herpes Simplex Virus 1 (HSV-1) ICP22 Protein Directly Interacts with Cyclin-Dependent Kinase (CDK)9 to Inhibit RNA Polymerase II Transcription Elongation

(2014) Justyna Zaborowska et al.   PLoS One

A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat

(2014) Nina Verstraete et al.   Retrovirology

A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription

(2014) Alona Kuzmina et al.   Retrovirology

MYC and Transcription Elongation

(2014) P. B. Rahl et al.   Cold Spring Harbor Perspectives in Medicine

The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

(2014) Stefania Bottardi et al.   PLoS Genetics

Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer

(2014) Ruichuan Chen et al.   Biomed Research International

Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation

(2014) Sergei Nekhai et al.   Biomed Research International

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

(2014) Xiaodan Ji et al.   eLife

Cyclin-Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines

(2014) Jasper H. N. Yik et al.   Arthritis & Rheumatology

The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code

(2013) Dirk Eick et al.   CHEMICAL REVIEWS

Cyclin-dependent kinase inhibitor therapy for hematologic malignancies

(2013) Prithviraj Bose et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription

(2013) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus L-E1A Activates Transcription through Mediator Complex-Dependent Recruitment of the Super Elongation Complex

(2013) S. Vijayalingam et al.   JOURNAL OF VIROLOGY

Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice

(2013) Noritada Yoshikawa et al.   PLoS One

Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle

(2013) Rebecca Gupte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

(2013) H. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lost in Transcription: Molecular Mechanisms that Control HIV Latency

(2013) Ran Taube et al.   Viruses-Basel

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

(2013) Uri R. Mbonye et al.   PLoS Pathogens

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

(2013) Gonçalo Castelo-Branco et al.   GENOME BIOLOGY

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

(2013) Alessandro Natoni et al.   Cancers

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Novel, Selective CDK9 Inhibitors for the Treatment of HIV Infection

(2012) G. Nemeth et al.   CURRENT MEDICINAL CHEMISTRY

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

(2012) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LARP7 is a potential tumor suppressor gene in gastric cancer

(2012) Yulan Cheng et al.   LABORATORY INVESTIGATION

Flavopiridol, the First Cyclin-Dependent Kinase Inhibitor: Recent Advances in Combination Chemotherapy

(2012) L.-M. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

(2012) Koh Fujinaga et al.   NUCLEIC ACIDS RESEARCH

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

(2012) Partha Mitra et al.   NUCLEIC ACIDS RESEARCH

Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis

(2012) Keqing Wang et al.   PLoS One

Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

(2012) Lei Guo et al.   PLoS One

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4+ T cells and inhibits HIV-1 gene expression

(2012) Sona Budhiraja et al.   Retrovirology

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

(2012) Nadine Czudnochowski et al.   Nature Communications

Ser-634 and Ser-636 of Kaposi’s Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites

(2012) Wan-Hua Tsai et al.   Frontiers in Microbiology

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Perspective: Expanding role of cyclin dependent kinases in cytokine inducible gene expression

(2011) Allan R. Brasier   CELL CYCLE

The Control of HIV Transcription: Keeping RNA Polymerase II on Track

(2011) Melanie Ott et al.   Cell Host & Microbe

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway

(2011) Rajesh Ramakrishnan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

(2011) Young Kyeung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties

(2011) K C Goh et al.   LEUKEMIA

Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription

(2011) Sonal M. Manohar et al.   LEUKEMIA RESEARCH

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription

(2011) Kristina Žumer et al.   NUCLEIC ACIDS RESEARCH

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

(2011) Tatiana Ammosova et al.   PLoS One

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

(2011) N. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

(2011) G Polier et al.   Cell Death & Disease

RNA Polymerase II Stalling Promotes Nucleosome Occlusion and pTEFb Recruitment to Drive Immortalization by Epstein-Barr Virus

(2011) Richard D. Palermo et al.   PLoS Pathogens

7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription

(2011) B. Matija Peterlin et al.   Wiley Interdisciplinary Reviews-RNA

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation

(2010) Sergei Nechaev et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

(2010) Gaetano Romano et al.   CELL CYCLE

P-TEFb joins the family of cdks in oncology, promotes cell growth of cancer cells

(2010) Nora M. Navone   CELL CYCLE

CYCLINg through transcription: Post-translational modifications of P-TEFb regulate transcription elongation

(2010) Sungyoo Cho et al.   CELL CYCLE

Cyclin T1 overexpression induces malignant transformation and tumor growth

(2010) Cristian Moiola et al.   CELL CYCLE

Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma

(2010) Wei-Gang Tong et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

(2010) Kannanganattu V. Prasanth et al.   MOLECULAR BIOLOGY OF THE CELL

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor

(2010) Gaelle Diribarne et al.   RNA Biology

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Mechanisms of HIV Latency: an Emerging Picture of Complexity

(2010) David M. Margolis   Current HIV/AIDS Reports

Recent developments in cyclin-dependent kinase biochemical and structural studies

(2009) Aude Echalier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1

(2009) Jorge Espinoza-Derout et al.   CIRCULATION RESEARCH

DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation

(2009) Y. Chen et al.   GENES & DEVELOPMENT

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective control of gene expression by CDK9 in human cells

(2009) Judit Garriga et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes

(2009) Rajesh Ramakrishnan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pharmacological targeting of CDK9 in cardiac hypertrophy

(2009) Vladimír Kryštof et al.   MEDICINAL RESEARCH REVIEWS

Using ChIP-chip and ChIP-seq to study the regulation of gene expression: Genome-wide localization studies reveal widespread regulation of transcription elongation

(2009) Daniel A. Gilchrist et al.   METHODS

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-TEFb- the final frontier

(2009) Jiri Kohoutek   Cell Division

RNA-driven cyclin-dependent kinase regulation: When CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners

(2008) Annemieke A. Michels et al.   Biotechnology Journal

The multi-tasking P-TEFb complex

(2008) Vanessa Brès et al.   CURRENT OPINION IN CELL BIOLOGY

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk9‐55: A new player in muscle regeneration

(2008) Cristina Giacinti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat

(2008) J. K. Jadlowsky et al.   JOURNAL OF GENERAL VIROLOGY

The Positive Transcription Elongation Factor b Is an Essential Cofactor for the Activation of Transcription by Myocyte Enhancer Factor 2

(2008) Masanori Nojima et al.   JOURNAL OF MOLECULAR BIOLOGY

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH

Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

(2008) Julie K Jadlowsky et al.   Retrovirology

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology

(2008) S WANG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mutation of the HEXIM1 Gene Results in Defects During Heart and Vascular Development Partly Through Downregulation of Vascular Endothelial Growth Factor

(2007) Monica M. Montano et al.   CIRCULATION RESEARCH