Review
Pharmacology & Pharmacy
Zahra Memariani, Syed Qamar Abbas, Syed Shams Ul Hassan, Amirhossein Ahmadi, Aroona Chabra
Summary: Cancer rates are increasing in many low- and middle-income countries due to various factors, including lifestyle changes and societal problems. Different treatment approaches like chemotherapy, surgery, and radiation therapy are used, but can have various short- and long-term side effects. Recent studies show that compounds like naringin and naringenin from citrus fruits have anti-cancer properties through different signaling pathways, and when combined with current anti-cancer agents, can show synergistic effects and help overcome multidrug resistance in cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Kent T. J. Chen, Gardenia G. C. Militao, Malathi Anantha, Dominik Witzigmann, Ada W. Y. Leung, Marcel B. Bally
Summary: A new method for preparing flavopiridol with copper-binding capabilities to enhance its solubility and therapeutic efficacy has been developed by the research team. The liposomal flavopiridol formulations were well-tolerated in mice and demonstrated significant therapeutic activity. Further studies are needed to explore potential formulation changes to enhance flavopiridol retention and improve therapeutic outcomes.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Fang Tang, Aixiang Ding, Yao Xu, Yingsong Ye, Lin Li, Rongjun Xie, Wei Huang
Summary: The integration of gene therapy and photothermal therapy offers a promising approach for cancer treatment, providing rapid response and improved effectiveness. Recent advancements in this field have resulted in notable achievements and progress towards potential clinical applications. However, challenges and future developments still need to be addressed. This comprehensive review explores the synergistic mechanisms, material systems, imaging-guided therapy, and anticancer applications of gene therapy and photothermal therapy integration, aiming to inspire further research in this promising area.
Review
Nutrition & Dietetics
Getinet M. Adinew, Equar Taka, Patricia Mendonca, Samia S. Messeha, Karam F. A. Soliman
Summary: Flavonoids, as new promising molecules, show various biological activities and can modulate miRNAs to affect the progression of TNBC, emphasizing their potential role in the prevention and treatment of TNBC.
Review
Biochemistry & Molecular Biology
Wamidh H. Talib, Dima Awajan, Reem Ali Hamed, Aya O. Azzam, Asma Ismail Mahmod, Intisar Hadi AL-Yasari
Summary: Cancer, as a prevalent disease globally, poses a significant health challenge and a major barrier to longevity. Plant-derived natural products, with their multiple mechanisms of action, structural diversity, availability in nature, and relatively low toxicity, show great potential in cancer treatment.
Article
Biochemistry & Molecular Biology
Carla M. Magalhaes, Patricia Gonzalez-Berdullas, Mariana Pereira, Diana Duarte, Nuno Vale, Joaquim C. G. Esteves da Silva, Luis Pinto da Silva
Summary: Cancer is a challenging disease to treat, and this study focuses on the design, synthesis, and evaluation of different brominated coelenteramines as potential anticancer molecules. The results highlight the importance of the 4-bromophenyl moiety for their anticancer activity and suggest independent mechanisms of action compared to coelenterazines. One of the studied coelenteramines showed promise in improving the profile of a known chemotherapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Chunhoo Cheon, Seong-Gyu Ko
Summary: This study reviewed the research on the combination of anticancer drugs and natural products for the treatment of prostate cancer and found that coadministration of natural products can enhance the efficacy of anticancer drugs. However, there is a lack of studies in this field and further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Na Liu, Mengfang Liu, Shengqiao Fu, Jinglei Wang, Haowen Tang, Adamu Danbala Isah, Deyu Chen, Xu Wang
Summary: This article introduces the role of Ang2 in different cancers and pathological conditions, as well as the inhibitory effect of blocking Ang2 on cancer cell growth and metastasis. The mechanisms regulating Ang2 expression, the importance of Ang2 in cancer growth, metastasis, and prognosis, and the research and challenges of combining Ang2 inhibition with chemotherapy, immunotherapy, and radiotherapy to enhance treatment efficacy are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Jiayan Wu, Kanyi Pu
Summary: Semiconducting polymer nanoparticles (SPNs) have been widely used in tumor treatment. Through modification, SPNs can encapsulate or conjugate with various types of immune modulators. This review summarizes the recent progress of SPNs-based combination cancer immunotherapy and highlights the synergetic effect that amplifies the anti-tumor immune response.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci
Summary: Prostate cancer is the second most common cancer in men. Higher intake of polyphenols, curcumin, and quercetin has been associated with lower prostate cancer risk. In this study, the combination of curcumin and quercetin showed synergic anticancer and anti-inflammatory effects, inhibiting proliferation, inducing apoptosis, and modulating inflammation-mediated signaling pathways.
Article
Chemistry, Medicinal
Fu Hou Wong, Vijayaraj Kumar Palanirajan, Edmond Siah Chye Ng, Chung Keat Tan, Eugenie Sin Sing Tan, Farahnaz Amini
Summary: This study investigated the effect of combined treatment with calcitriol and talazoparib on triple-negative breast cancer cell lines. The combination significantly inhibited cell proliferation and migration, induced apoptosis and necrosis. This combination could be a promising treatment option for triple-negative breast cancer.
Review
Nanoscience & Nanotechnology
Yingli Wu, Yu Yang, Xiaolin Lv, Menghan Gao, Xujin Gong, Qingqiang Yao, Yanna Liu
Summary: Ovarian cancer is commonly treated with combination therapy, such as paclitaxel and platinum anticancer drug. Nanoparticles provide opportunities to overcome the limitations of combination therapy by improving drug properties and increasing drug accumulation in targeted tissues. This review summarizes nanoparticle-based combination therapies for ovarian cancer, highlighting the advantages of nanocarriers in combination treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Xin Li, Wenkai Jiang, Shi Dong, Wancheng Li, Weixiong Zhu, Wence Zhou
Summary: This review discusses the relationship between STAT3 and pancreatic cancer, as well as the latest research on the use of STAT3 inhibitors in pancreatic cancer, aiming to provide insights and ideas for a new generation of chemotherapeutic modalities for pancreatic cancer.
Article
Oncology
Yang Hao, Zili Gu, Zhenfeng Yu, Timo Schomann, Sana Sayedipour, Julio C. Aguilar, Peter ten Dijke, Luis J. Cruz
Summary: This study demonstrates that combination therapy of photodynamic therapy (PDT) and viral vaccine can enhance anti-cancer immunity and prevent tumor recurrence. The combination treatment improved innate and humoral immunity, increased survival rate, and generated long-term immune memory in a murine colorectal tumor model.
Review
Biotechnology & Applied Microbiology
Jiangbin Chen, Qi Tan, Zimo Yang, Yang Jin
Summary: Extracellular vesicles (EVs) are secretory vesicles with cell-derived membrane and contents, which can be designed as drug delivery platforms for cancer therapy due to their cargo delivery capability. With biocompatibility and immune compatibility, EVs have unique advantages compared with other nanocarriers. Engineered EVs can be modified to achieve desired performance and have potential for various combinations of cancer treatment methods. Application of engineered EVs in cancer therapy is shifting towards combinational therapy to combat heterogeneous cancer cells and complex tumor microenvironment, highlighting the need for more effective treatment plans in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
