Cyclin-Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines

Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors

(2014) C. Sekine et al.   JOURNAL OF IMMUNOLOGY

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

(2012) Vladimir Krystof et al.   CURRENT PHARMACEUTICAL DESIGN

Flavopiridol, the First Cyclin-Dependent Kinase Inhibitor: Recent Advances in Combination Chemotherapy

(2012) L.-M. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis

(2012) B.A. Christiansen et al.   OSTEOARTHRITIS AND CARTILAGE

Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis

(2012) Keqing Wang et al.   PLoS One

Glatiramer acetate (GA), the immunomodulatory drug, inhibits inflammatory mediators and collagen degradation in osteoarthritis (OA) cartilage

(2011) M. Attur et al.   OSTEOARTHRITIS AND CARTILAGE

Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFβ-responsive gene

(2011) H. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9

(2010) Ulrike K. Schmerwitz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synovial Fluid Biomarkers for Periprosthetic Infection

(2010) Carl Deirmengian et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition

(2010) Wenjun Ni et al.   PLoS One

Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint

(2010) Ugo Fiocco et al.   ARTHRITIS RESEARCH & THERAPY

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

(2010) Martin K Lotz   ARTHRITIS RESEARCH & THERAPY

The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

(2009) S. Ali et al.   CANCER RESEARCH

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

(2009) Alessio Zippo et al.   CELL

Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

(2008) M B Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES